MBD3 and PFDN6

Data Source:
BioGRID (two hybrid)

		MBD3	PFDN6
Description		methyl-CpG binding domain protein 3	prefoldin subunit 6
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GO Annotations	Cellular Component	Chromatin Heterochromatin Nucleoplasm Cytoplasm NuRD Complex Protein-containing Complex	Cytoplasm Prefoldin Complex
	Molecular Function	DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding	Amyloid-beta Binding Protein Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development DNA Methylation-dependent Heterochromatin Assembly Brain Development Heart Development Aging Tissue Development Histone Acetylation Response To Nutrient Levels Response To Estradiol ATP-dependent Chromatin Remodeling Regulation Of DNA Methylation Embryonic Organ Development Regulation Of Signal Transduction By P53 Class Mediator	Protein Folding Chaperone-mediated Protein Complex Assembly Negative Regulation Of Amyloid Fibril Formation
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS	Prefoldin mediated transfer of substrate to CCT/TriC
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		76 interacting genes: AGR2 ANKRD33 ASCL4 ATF7 AURKA BCL11B CCDC183 CCHCR1 CCNC CENPP CEP70 CEP76 CT55 ERCC6 EXOC4 FAM136A GADD45GIP1 GATAD2A GATAD2B GOLGA2 GOLGA6L9 H3-4 HDAC1 ICA1 IGFBP6 IK JUN KDM1A KDM5B KRT15 KRT16 LDOC1 LMO3 MAGEA2 MAGEA2B MBD2 MBD3L1 MBD3L2 MECOM MEIS3 MEOX1 MEOX2 MIPOL1 MKRN3 MTA2 MTUS2 MYOG NUTM1 PBX4 PDGFA PFDN6 PICK1 PKNOX2 PRKAR1B RAB3IP RBBP4 RBBP7 RCN3 REL RINT1 SDCBP SERTAD3 SMARCA4 SPEN STMN2 SYCE1 TBC1D19 TET1 TIMM10B TNNI1 TRIM54 TTC23 USP11 ZBTB7A ZNF277 ZNF655	12 interacting genes: AIMP2 B4GALT2 CCHCR1 CEBPG FBXO2 KANK2 KIFC3 MAGEB4 MBD3 PFDN5 RPRD1B THAP11
Entrez ID		53615	10471
HPRD ID		04653	16135
Ensembl ID		ENSG00000071655	ENSG00000204220
Uniprot IDs		O95983	O15212 Q5STK2
PDB IDs		2MB7 6CC8 6CCG 6CEU 6CEV	6NR8 6NR9 6NRB 6NRC 6NRD
Enriched GO Terms of Interacting Partners?
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