Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
UBE2S and RBCK1
Data Source:
BioGRID
(two hybrid)
UBE2S
RBCK1
Description
ubiquitin conjugating enzyme E2 S
RANBP2-type and C3HC4-type zinc finger containing 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Ubiquitin Ligase Complex
Cytosol
LUBAC Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Anaphase-promoting Complex Binding
Ubiquitin Conjugating Enzyme Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Identical Protein Binding
Ubiquitin Binding
Metal Ion Binding
Biological Process
Protein Polyubiquitination
Cellular Protein Modification Process
Ubiquitin-dependent Protein Catabolic Process
Exit From Mitosis
Free Ubiquitin Chain Polymerization
Protein Ubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
Protein K29-linked Ubiquitination
Protein K27-linked Ubiquitination
Cell Division
Protein K63-linked Ubiquitination
Protein K11-linked Ubiquitination
Protein K6-linked Ubiquitination
Positive Regulation Of Ubiquitin Protein Ligase Activity
Protein Polyubiquitination
I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Viral Process
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Necroptotic Process
Protein Linear Polyubiquitination
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Night sleep phenotypes (
27126917
)
Interacting Genes
42 interacting genes:
AKT1
ANAPC1
ANAPC11
ANAPC2
ANAPC4
ANAPC5
ANAPC7
APP
ATXN3
BIRC2
CCNB1
CDC16
CDC20
CDC23
CDC27
CTNNB1
CYLD
FBXO5
FZR1
GMNN
HERC1
LINC00839
MDM2
OTUB1
OTUD7B
PRKN
PTEN
RBCK1
RNF7
STAMBP
UBA1
UBA6
UBB
UBC
UCHL3
USP15
USP2
USP21
USP5
USP7
VHL
ZRANB1
65 interacting genes:
APP
ARNT2
BACH1
CREB5
CREBBP
ENKD1
GLYCTK
HGS
HOXA1
HOXC8
IL16
IREB2
KANK2
LNX1
MALT1
MAP3K1
MAPKBP1
MKRN2
NAA10
NDUFAF3
NEDD4
NR1I2
OTUB2
OTUD6A
PAN2
PCGF2
PRKCA
PRKN
PSMA1
PSMD4
RNF181
RNF31
SMURF1
SOCS6
SYCE1
TNFAIP3
TP53
TRAF1
TRIM21
TRIM25
TRIM65
TRIML1
TSSK3
TTC23
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2G1
UBE2K
UBE2L3
UBE2L6
UBE2N
UBE2S
UBE2U
UCHL5
UHRF2
USP15
USP2
USP21
USP32
USP49
USP7
ZNF414
Entrez ID
27338
10616
HPRD ID
15603
16643
Ensembl ID
ENSG00000108106
ENSG00000125826
Uniprot IDs
Q16763
A6PVJ6
A6PVK0
Q9BYM8
PDB IDs
1ZDN
5BNB
5L9T
6QH3
6QHK
6S96
6S98
2CRC
2LGY
4DBG
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?