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UBE2S and UCHL3
Data Source:
BioGRID
(enzymatic study)
UBE2S
UCHL3
Description
ubiquitin conjugating enzyme E2 S
ubiquitin C-terminal hydrolase L3
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Anaphase-promoting Complex Binding
Ubiquitin Conjugating Enzyme Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Peptidase Activity
NEDD8-specific Protease Activity
Ubiquitin Binding
Biological Process
Protein Polyubiquitination
Cellular Protein Modification Process
Ubiquitin-dependent Protein Catabolic Process
Exit From Mitosis
Free Ubiquitin Chain Polymerization
Protein Ubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
Protein K29-linked Ubiquitination
Protein K27-linked Ubiquitination
Cell Division
Protein K63-linked Ubiquitination
Protein K11-linked Ubiquitination
Protein K6-linked Ubiquitination
Positive Regulation Of Ubiquitin Protein Ligase Activity
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Protein Deubiquitination
Protein Phosphopantetheinylation
Protein Catabolic Process
Post-translational Protein Modification
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
UCH proteinases
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Neddylation
Drugs
Diseases
GWAS
Diabetic retinopathy (
23562823
)
Metabolite levels (
23823483
)
Interacting Genes
42 interacting genes:
AKT1
ANAPC1
ANAPC11
ANAPC2
ANAPC4
ANAPC5
ANAPC7
APP
ATXN3
BIRC2
CCNB1
CDC16
CDC20
CDC23
CDC27
CTNNB1
CYLD
FBXO5
FZR1
GMNN
HERC1
LINC00839
MDM2
OTUB1
OTUD7B
PRKN
PTEN
RBCK1
RNF7
STAMBP
UBA1
UBA6
UBB
UBC
UCHL3
USP15
USP2
USP21
USP5
USP7
VHL
ZRANB1
20 interacting genes:
ATM
ATXN7L3
CDH1
FOXM1
LONRF1
NEDD8
NSG2
PJA1
PLA2G2A
POGK
RAD51
TRIM27
TRIM54
TRIM55
TRIM63
UBE2S
USP15
USP21
USP28
XRCC5
Entrez ID
27338
7347
HPRD ID
15603
04367
Ensembl ID
ENSG00000108106
ENSG00000118939
Uniprot IDs
Q16763
A0A087WTB8
A0A140VJZ4
P15374
PDB IDs
1ZDN
5BNB
5L9T
6QH3
6QHK
6S96
6S98
1UCH
1XD3
6ISU
6QML
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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