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UBE2S and LINC00839
Data Source:
BioGRID
(unspecified method)
UBE2S
LINC00839
Description
ubiquitin conjugating enzyme E2 S
long intergenic non-protein coding RNA 839
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Anaphase-promoting Complex Binding
Ubiquitin Conjugating Enzyme Activity
Biological Process
Protein Polyubiquitination
Cellular Protein Modification Process
Ubiquitin-dependent Protein Catabolic Process
Exit From Mitosis
Free Ubiquitin Chain Polymerization
Protein Ubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
Protein K29-linked Ubiquitination
Protein K27-linked Ubiquitination
Cell Division
Protein K63-linked Ubiquitination
Protein K11-linked Ubiquitination
Protein K6-linked Ubiquitination
Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Interacting Genes
42 interacting genes:
AKT1
ANAPC1
ANAPC11
ANAPC2
ANAPC4
ANAPC5
ANAPC7
APP
ATXN3
BIRC2
CCNB1
CDC16
CDC20
CDC23
CDC27
CTNNB1
CYLD
FBXO5
FZR1
GMNN
HERC1
LINC00839
MDM2
OTUB1
OTUD7B
PRKN
PTEN
RBCK1
RNF7
STAMBP
UBA1
UBA6
UBB
UBC
UCHL3
USP15
USP2
USP21
USP5
USP7
VHL
ZRANB1
82 interacting genes:
ADAMTS15
AKAP13
ALDH16A1
APOL3
BFSP1
CALM1
CC2D1B
CCDC168
CCDC93
CDC16
CEP192
CEP295NL
CHPF
CIZ1
CLGN
CLPTM1
COPB1
DNAH10
DPEP3
EFL1
EID2
EMX1
FAAP100
FAM13B
FBXL5
HAPLN4
IQCN
IRX4
JAKMIP2
KLK14
KRT1
KRT6B
L1CAM
MEX3A
MEX3B
MEX3C
MEX3D
MICAL2
MYO7A
NDUFA2
NOC4L
NOTCH3
NVL
OS9
P4HB
PABPN1
PALM3
PARP6
PHACTR1
PKD1L2
PLOD3
PNPLA3
POMT2
PRSS1
PRSS3
PTBP1
PTEN
PTPRA
QSOX2
RAPGEF6
RIF1
RPLP2
RPTOR
RYR2
SEMA4D
SEPTIN12
SEPTIN9
SERHL2
SLC7A14
SOWAHB
SREBF2
SYNE1
SYNE3
TAS1R3
TCF24
TMC4
TRO
UBE2S
VANGL1
YAP1
YIPF1
ZFPL1
Entrez ID
27338
84856
HPRD ID
15603
17516
Ensembl ID
ENSG00000108106
ENSG00000185904
Uniprot IDs
Q16763
PDB IDs
1ZDN
5BNB
5L9T
6QH3
6QHK
6S96
6S98
Enriched GO Terms of Interacting Partners
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