UBE2S and UBA6

Data Source:
BioGRID (pull down)

		UBE2S	UBA6
Description		ubiquitin conjugating enzyme E2 S	ubiquitin like modifier activating enzyme 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol	Nucleus Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Anaphase-promoting Complex Binding Ubiquitin Conjugating Enzyme Activity	Ubiquitin Activating Enzyme Activity Protein Binding ATP Binding FAT10 Activating Enzyme Activity
	Biological Process	Protein Polyubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Cell Division Protein K63-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity	Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Learning Locomotory Behavior Protein Ubiquitination Protein Phosphopantetheinylation Amygdala Development Hippocampus Development Protein Modification By Small Protein Conjugation Dendritic Spine Development
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Regular attendance at a pub or social club ( 29970889)
Interacting Genes		42 interacting genes: AKT1 ANAPC1 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 APP ATXN3 BIRC2 CCNB1 CDC16 CDC20 CDC23 CDC27 CTNNB1 CYLD FBXO5 FZR1 GMNN HERC1 LINC00839 MDM2 OTUB1 OTUD7B PRKN PTEN RBCK1 RNF7 STAMBP UBA1 UBA6 UBB UBC UCHL3 USP15 USP2 USP21 USP5 USP7 VHL ZRANB1	16 interacting genes: HMBOX1 JUNB LMO2 OTUB1 SMAD9 UBC UBD UBE2D1 UBE2D2 UBE2D3 UBE2G2 UBE2L3 UBE2L6 UBE2S UBE2T UBE2Z
Entrez ID		27338	55236
HPRD ID		15603	13341
Ensembl ID		ENSG00000108106	ENSG00000033178
Uniprot IDs		Q16763	A0AVT1 A1LT96
PDB IDs		1ZDN 5BNB 5L9T 6QH3 6QHK 6S96 6S98
Enriched GO Terms of Interacting Partners?
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