AREL1 and HTRA2

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		AREL1	HTRA2
Description		apoptosis resistant E3 ubiquitin protein ligase 1	HtrA serine peptidase 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Chromatin Nucleus Mitochondrion Mitochondrial Intermembrane Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Cytoplasmic Side Of Plasma Membrane Membrane Mitochondrial Membrane CD40 Receptor Complex Serine-type Endopeptidase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Identical Protein Binding Unfolded Protein Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Inflammatory Response	Proteolysis Ceramide Metabolic Process Mitochondrion Organization Aging Adult Walking Behavior Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Herbicide Positive Regulation Of Mitochondrion Organization Programmed Cell Death Protein Autoprocessing Pentacyclic Triterpenoid Metabolic Process Forebrain Development Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Interferon-beta Regulation Of Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Protein Catabolic Process Negative Regulation Of Cell Cycle Neuron Development Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Execution Phase Of Apoptosis Negative Regulation Of Neuron Death Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Mitophagy In Response To Mitochondrial Depolarization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Parkinson's disease (PD)
GWAS		General factor of neuroticism ( 30867560) Mood instability ( 29187730)
Interacting Genes		10 interacting genes: CRKL DIABLO HTRA2 PIAS4 SEPTIN4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3	39 interacting genes: - ACTA1 ALDH1A2 APC APP AREL1 BIRC2 BIRC3 BIRC6 BIRC7 CAD CCAR2 CDK1 CDK5 CSN1S1 CSN2 DIABLO EEF1A1 EIF4G1 HSD17B10 IMMT MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MUL1 PAG1 PDXDC1 PEA15 TRIM28 TUBA1A TUBB TUBB6 TUBB7P USP7 VIM VPS4B XIAP
Entrez ID		9870	27429
HPRD ID		13794	05919
Ensembl ID		ENSG00000119682	ENSG00000115317
Uniprot IDs		O15033	A0A384MDW9 O43464
PDB IDs		6JX5	1LCY 2PZD 5FHT 5M3N 5M3O 5TNY 5TNZ 5TO0 5TO1 5WYN
Enriched GO Terms of Interacting Partners?
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