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HTRA2 and MUL1
Data Source:
BioGRID
(enzymatic study)
HTRA2
MUL1
Description
HtrA serine peptidase 2
mitochondrial E3 ubiquitin protein ligase 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Mitochondrion
Mitochondrial Intermembrane Space
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Cytoskeleton
Cytoplasmic Side Of Plasma Membrane
Membrane
Mitochondrial Membrane
CD40 Receptor Complex
Serine-type Endopeptidase Complex
Mitochondrion
Peroxisome
Membrane
Axon
Integral Component Of Mitochondrial Outer Membrane
Neuronal Cell Body
Molecular Function
Serine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Serine-type Peptidase Activity
Identical Protein Binding
Unfolded Protein Binding
P53 Binding
Ubiquitin-protein Transferase Activity
Protein Binding
SUMO Transferase Activity
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Proteolysis
Ceramide Metabolic Process
Mitochondrion Organization
Aging
Adult Walking Behavior
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Herbicide
Positive Regulation Of Mitochondrion Organization
Programmed Cell Death
Protein Autoprocessing
Pentacyclic Triterpenoid Metabolic Process
Forebrain Development
Cellular Response To Oxidative Stress
Cellular Response To Heat
Cellular Response To Interferon-beta
Regulation Of Multicellular Organism Growth
Positive Regulation Of Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Protein Catabolic Process
Negative Regulation Of Cell Cycle
Neuron Development
Cellular Response To Retinoic Acid
Cellular Response To Growth Factor Stimulus
Execution Phase Of Apoptosis
Negative Regulation Of Neuron Death
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Protein Polyubiquitination
Mitochondrial Fission
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Activation Of JUN Kinase Activity
Negative Regulation Of Mitochondrial Fusion
Regulation Of Mitochondrion Organization
Protein Ubiquitination
Protein Sumoylation
Negative Regulation Of Cell Growth
Protein Destabilization
Positive Regulation Of Protein Sumoylation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Innate Immune Response
Negative Regulation Of Defense Response To Virus By Host
Protein Stabilization
Mitochondrion Localization
Regulation Of Mitochondrial Membrane Potential
Negative Regulation Of Protein Kinase B Signaling
Negative Regulation Of Type I Interferon-mediated Signaling Pathway
Cellular Response To Exogenous DsRNA
Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production
Positive Regulation Of Mitochondrial Fission
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Positive Regulation Of Dendrite Extension
Positive Regulation Of Autophagy Of Mitochondrion In Response To Mitochondrial Depolarization
Pathways
Ub-specific processing proteases
Drugs
Diseases
Parkinson's disease (PD)
GWAS
Proportion of activated microglia (inferior temporal cortex) (
30679421
)
Interacting Genes
39 interacting genes:
-
ACTA1
ALDH1A2
APC
APP
AREL1
BIRC2
BIRC3
BIRC6
BIRC7
CAD
CCAR2
CDK1
CDK5
CSN1S1
CSN2
DIABLO
EEF1A1
EIF4G1
HSD17B10
IMMT
MAPK11
MAPK12
MAPK13
MAPK14
MAPK3
MUL1
PAG1
PDXDC1
PEA15
TRIM28
TUBA1A
TUBB
TUBB6
TUBB7P
USP7
VIM
VPS4B
XIAP
34 interacting genes:
AKT1
APPBP2
CDC34
DNM1L
EHD1
HTRA2
KRTAP10-8
MAP3K7
RANGAP1
REEP2
STING1
SUMO1
TAP1
TP53
TP73
TRIM9
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G2
UBE2L3
UBE2L6
UBE2N
UBE2R2
UBE2U
UBE2V2
UBE2W
UBXN7
ULK1
Entrez ID
27429
79594
HPRD ID
05919
07799
Ensembl ID
ENSG00000115317
ENSG00000090432
Uniprot IDs
A0A384MDW9
O43464
A1PUM0
Q969V5
PDB IDs
1LCY
2PZD
5FHT
5M3N
5M3O
5TNY
5TNZ
5TO0
5TO1
5WYN
6K2K
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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