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HTRA2 and CCAR2
Data Source:
BioGRID
(unspecified method, enzymatic study)
HTRA2
CCAR2
Description
HtrA serine peptidase 2
cell cycle and apoptosis regulator 2
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Mitochondrion
Mitochondrial Intermembrane Space
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Cytoskeleton
Cytoplasmic Side Of Plasma Membrane
Membrane
Mitochondrial Membrane
CD40 Receptor Complex
Serine-type Endopeptidase Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrial Matrix
Spindle
DBIRD Complex
Molecular Function
Serine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Serine-type Peptidase Activity
Identical Protein Binding
Unfolded Protein Binding
RNA Polymerase II Complex Binding
RNA Binding
Enzyme Inhibitor Activity
Protein Binding
Enzyme Binding
Nuclear Receptor Coactivator Activity
Biological Process
Proteolysis
Ceramide Metabolic Process
Mitochondrion Organization
Aging
Adult Walking Behavior
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Herbicide
Positive Regulation Of Mitochondrion Organization
Programmed Cell Death
Protein Autoprocessing
Pentacyclic Triterpenoid Metabolic Process
Forebrain Development
Cellular Response To Oxidative Stress
Cellular Response To Heat
Cellular Response To Interferon-beta
Regulation Of Multicellular Organism Growth
Positive Regulation Of Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Protein Catabolic Process
Negative Regulation Of Cell Cycle
Neuron Development
Cellular Response To Retinoic Acid
Cellular Response To Growth Factor Stimulus
Execution Phase Of Apoptosis
Negative Regulation Of Neuron Death
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Regulation Of Transcription, DNA-templated
MRNA Processing
Cellular Response To DNA Damage Stimulus
Cell Cycle
RNA Splicing
Response To UV
Wnt Signaling Pathway
Negative Regulation Of Cell Growth
Regulation Of Protein Stability
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of DNA-templated Transcription, Elongation
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Negative Regulation Of Catalytic Activity
Mitochondrial Fragmentation Involved In Apoptotic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Rhythmic Process
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Protein Deacetylation
Regulation Of Cellular Response To Heat
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of DNA Damage Checkpoint
Pathways
Regulation of HSF1-mediated heat shock response
Drugs
Diseases
Parkinson's disease (PD)
GWAS
Interacting Genes
39 interacting genes:
-
ACTA1
ALDH1A2
APC
APP
AREL1
BIRC2
BIRC3
BIRC6
BIRC7
CAD
CCAR2
CDK1
CDK5
CSN1S1
CSN2
DIABLO
EEF1A1
EIF4G1
HSD17B10
IMMT
MAPK11
MAPK12
MAPK13
MAPK14
MAPK3
MUL1
PAG1
PDXDC1
PEA15
TRIM28
TUBA1A
TUBB
TUBB6
TUBB7P
USP7
VIM
VPS4B
XIAP
9 interacting genes:
AR
BAG2
ELL
HTRA2
IKBKB
MYC
NLGN3
SUMO2
ZNF335
Entrez ID
27429
57805
HPRD ID
05919
09159
Ensembl ID
ENSG00000115317
ENSG00000158941
Uniprot IDs
A0A384MDW9
O43464
Q8N163
PDB IDs
1LCY
2PZD
5FHT
5M3N
5M3O
5TNY
5TNZ
5TO0
5TO1
5WYN
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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