HTRA2 and ALDH1A2

Data Source:
BioGRID (unspecified method)

		HTRA2	ALDH1A2
Description		HtrA serine peptidase 2	aldehyde dehydrogenase 1 family member A2
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GO Annotations	Cellular Component	Chromatin Nucleus Mitochondrion Mitochondrial Intermembrane Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Cytoplasmic Side Of Plasma Membrane Membrane Mitochondrial Membrane CD40 Receptor Complex Serine-type Endopeptidase Complex	Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Identical Protein Binding Unfolded Protein Binding	Retinal Dehydrogenase Activity 3-chloroallyl Aldehyde Dehydrogenase Activity Aldehyde Dehydrogenase (NAD+) Activity Retinal Binding
	Biological Process	Proteolysis Ceramide Metabolic Process Mitochondrion Organization Aging Adult Walking Behavior Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Herbicide Positive Regulation Of Mitochondrion Organization Programmed Cell Death Protein Autoprocessing Pentacyclic Triterpenoid Metabolic Process Forebrain Development Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Interferon-beta Regulation Of Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Protein Catabolic Process Negative Regulation Of Cell Cycle Neuron Development Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Execution Phase Of Apoptosis Negative Regulation Of Neuron Death Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Mitophagy In Response To Mitochondrial Depolarization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Blood Vessel Development Kidney Development Liver Development Regulation Of Endothelial Cell Proliferation Retinoic Acid Biosynthetic Process Heart Morphogenesis Vitamin A Metabolic Process Midgut Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Determination Of Bilateral Symmetry Proximal/distal Pattern Formation Positive Regulation Of Gene Expression Neural Crest Cell Development Morphogenesis Of Embryonic Epithelium Neural Tube Development Pituitary Gland Development Neuron Differentiation Lung Development Hindbrain Development Pancreas Development Embryonic Camera-type Eye Development Response To Estradiol Response To Vitamin A Response To Cytokine Embryonic Forelimb Morphogenesis Ureter Maturation Retinol Metabolic Process Retinoic Acid Metabolic Process Retinal Metabolic Process 9-cis-retinoic Acid Biosynthetic Process Positive Regulation Of Apoptotic Process Embryonic Digestive Tract Development Cardiac Muscle Tissue Development Protein Homotetramerization Face Development Cellular Response To Retinoic Acid Retinoic Acid Receptor Signaling Pathway Involved In Somitogenesis
Pathways			RA biosynthesis pathway
Drugs			NADH Vitamin A Tretinoin
Diseases		Parkinson's disease (PD)
GWAS			Barrett's esophagus ( 27527254) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Brain morphology (MOSTest) ( 32665545) Cholesterol ( 31902109) Diisocyanate-induced asthma ( 25918132) Eosinophil counts ( 32888494) HDL cholesterol ( 28270201 30275531) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hypertension ( 19609347) Ischemic stroke ( 26089329) LDL cholesterol ( 30275531) Low density lipoprotein cholesterol levels ( 32154731) Low HDL-cholesterol levels ( 31910446) Lymphocyte counts ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Monocyte count ( 32888494) Osteoarthritis (hand, severe) ( 24728293) Red blood cell count ( 32888494) Small cell lung carcinoma ( 28604730) Stroke ( 26089329) Total cholesterol levels ( 30275531) Triglyceride levels ( 32154731) Uncontrolled blood pressure in combination therapy (beta blocker and thiazide diuretic) ( 29097388)
Interacting Genes		39 interacting genes: - ACTA1 ALDH1A2 APC APP AREL1 BIRC2 BIRC3 BIRC6 BIRC7 CAD CCAR2 CDK1 CDK5 CSN1S1 CSN2 DIABLO EEF1A1 EIF4G1 HSD17B10 IMMT MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MUL1 PAG1 PDXDC1 PEA15 TRIM28 TUBA1A TUBB TUBB6 TUBB7P USP7 VIM VPS4B XIAP	1 interacting genes: HTRA2
Entrez ID		27429	8854
HPRD ID		05919	04733
Ensembl ID		ENSG00000115317	ENSG00000128918
Uniprot IDs		A0A384MDW9 O43464	O94788
PDB IDs		1LCY 2PZD 5FHT 5M3N 5M3O 5TNY 5TNZ 5TO0 5TO1 5WYN	4X2Q 6ALJ 6B5G 6B5H 6B5I
Enriched GO Terms of Interacting Partners?
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