Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
HTRA2 and CAD
Data Source:
BioGRID
(unspecified method)
HTRA2
CAD
Description
HtrA serine peptidase 2
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Mitochondrion
Mitochondrial Intermembrane Space
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Cytoskeleton
Cytoplasmic Side Of Plasma Membrane
Membrane
Mitochondrial Membrane
CD40 Receptor Complex
Serine-type Endopeptidase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Membrane
Nuclear Matrix
Protein-containing Complex
Cell Projection
Neuronal Cell Body
Terminal Bouton
Extracellular Exosome
Molecular Function
Serine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Serine-type Peptidase Activity
Identical Protein Binding
Unfolded Protein Binding
Aspartate Carbamoyltransferase Activity
Carbamoyl-phosphate Synthase (glutamine-hydrolyzing) Activity
Dihydroorotase Activity
Protein Kinase Activity
ATP Binding
Zinc Ion Binding
Enzyme Binding
Identical Protein Binding
Aspartate Binding
Biological Process
Proteolysis
Ceramide Metabolic Process
Mitochondrion Organization
Aging
Adult Walking Behavior
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Herbicide
Positive Regulation Of Mitochondrion Organization
Programmed Cell Death
Protein Autoprocessing
Pentacyclic Triterpenoid Metabolic Process
Forebrain Development
Cellular Response To Oxidative Stress
Cellular Response To Heat
Cellular Response To Interferon-beta
Regulation Of Multicellular Organism Growth
Positive Regulation Of Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Protein Catabolic Process
Negative Regulation Of Cell Cycle
Neuron Development
Cellular Response To Retinoic Acid
Cellular Response To Growth Factor Stimulus
Execution Phase Of Apoptosis
Negative Regulation Of Neuron Death
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Liver Development
'de Novo' Pyrimidine Nucleobase Biosynthetic Process
UTP Biosynthetic Process
Glutamine Metabolic Process
Nitrogen Compound Metabolic Process
Heart Development
Female Pregnancy
Lactation
Response To Amine
Drug Metabolic Process
Peptidyl-threonine Phosphorylation
Citrulline Biosynthetic Process
Response To Caffeine
Animal Organ Regeneration
Response To Insulin
Response To Testosterone
Cellular Response To Drug
Response To Starvation
'de Novo' UMP Biosynthetic Process
Pyrimidine Nucleoside Biosynthetic Process
Protein Autophosphorylation
Response To Cortisol
Cellular Response To Epidermal Growth Factor Stimulus
Pathways
Pyrimidine biosynthesis
Drugs
Sparfosic acid
Diseases
Parkinson's disease (PD)
GWAS
Triglyceride levels (
32203549
)
Interacting Genes
39 interacting genes:
-
ACTA1
ALDH1A2
APC
APP
AREL1
BIRC2
BIRC3
BIRC6
BIRC7
CAD
CCAR2
CDK1
CDK5
CSN1S1
CSN2
DIABLO
EEF1A1
EIF4G1
HSD17B10
IMMT
MAPK11
MAPK12
MAPK13
MAPK14
MAPK3
MUL1
PAG1
PDXDC1
PEA15
TRIM28
TUBA1A
TUBB
TUBB6
TUBB7P
USP7
VIM
VPS4B
XIAP
11 interacting genes:
CASP3
HTRA2
MAPK1
NEDD4
PPP1CA
PPP2CA
PRKACA
PTEN
RAD9A
SUMO2
YWHAG
Entrez ID
27429
790
HPRD ID
05919
06437
Ensembl ID
ENSG00000115317
ENSG00000084774
Uniprot IDs
A0A384MDW9
O43464
F8VPD4
P27708
PDB IDs
1LCY
2PZD
5FHT
5M3N
5M3O
5TNY
5TNZ
5TO0
5TO1
5WYN
4BY3
4C6B
4C6C
4C6D
4C6E
4C6F
4C6I
4C6J
4C6K
4C6L
4C6M
4C6N
4C6O
4C6P
4C6Q
5G1N
5G1O
5G1P
5YNZ
6HFD
6HFE
6HFF
6HFH
6HFI
6HFJ
6HFK
6HFL
6HFN
6HFP
6HFQ
6HFR
6HFS
6HFU
6HG1
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?