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HTRA2 and MAPK12
Data Source:
BioGRID
(enzymatic study)
HTRA2
MAPK12
Description
HtrA serine peptidase 2
mitogen-activated protein kinase 12
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Mitochondrion
Mitochondrial Intermembrane Space
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Cytoskeleton
Cytoplasmic Side Of Plasma Membrane
Membrane
Mitochondrial Membrane
CD40 Receptor Complex
Serine-type Endopeptidase Complex
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Molecular Function
Serine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Serine-type Peptidase Activity
Identical Protein Binding
Unfolded Protein Binding
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
Biological Process
Proteolysis
Ceramide Metabolic Process
Mitochondrion Organization
Aging
Adult Walking Behavior
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Herbicide
Positive Regulation Of Mitochondrion Organization
Programmed Cell Death
Protein Autoprocessing
Pentacyclic Triterpenoid Metabolic Process
Forebrain Development
Cellular Response To Oxidative Stress
Cellular Response To Heat
Cellular Response To Interferon-beta
Regulation Of Multicellular Organism Growth
Positive Regulation Of Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Protein Catabolic Process
Negative Regulation Of Cell Cycle
Neuron Development
Cellular Response To Retinoic Acid
Cellular Response To Growth Factor Stimulus
Execution Phase Of Apoptosis
Negative Regulation Of Neuron Death
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
MAPK Cascade
DNA Damage Induced Protein Phosphorylation
Cell Cycle Arrest
Signal Transduction
Muscle Organ Development
Positive Regulation Of Peptidase Activity
Peptidyl-serine Phosphorylation
Intracellular Signal Transduction
Myoblast Differentiation
Positive Regulation Of Muscle Cell Differentiation
Pathways
NOD1/2 Signaling Pathway
p38MAPK events
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
DSCAM interactions
VEGFA-VEGFR2 Pathway
Myogenesis
Myogenesis
Negative regulation of MAPK pathway
Drugs
Minocycline
Phosphonothreonine
Phosphoaminophosphonic Acid-Adenylate Ester
KC706
CEP-1347
Diseases
Parkinson's disease (PD)
GWAS
Acne (severe) (
24927181
)
Diverticular disease (
30177863
)
Triiodothyronine levels and thyroxine levels (
30843173
)
Interacting Genes
39 interacting genes:
-
ACTA1
ALDH1A2
APC
APP
AREL1
BIRC2
BIRC3
BIRC6
BIRC7
CAD
CCAR2
CDK1
CDK5
CSN1S1
CSN2
DIABLO
EEF1A1
EIF4G1
HSD17B10
IMMT
MAPK11
MAPK12
MAPK13
MAPK14
MAPK3
MUL1
PAG1
PDXDC1
PEA15
TRIM28
TUBA1A
TUBB
TUBB6
TUBB7P
USP7
VIM
VPS4B
XIAP
29 interacting genes:
DLG1
DLG2
DLG3
DLG4
DUSP1
EEF2K
ERBIN
GRB2
GTF2I
HTRA2
MAP2K3
MAP2K4
MAP2K6
MAPKAPK5
MAPT
MBP
PATJ
PDGFRL
PKN1
PTPN3
PTPN4
RCSD1
RGS3
SH3BP5
SIAH1
SNTA1
SNTB1
SRPK1
TERF1
Entrez ID
27429
6300
HPRD ID
05919
03868
Ensembl ID
ENSG00000115317
ENSG00000188130
Uniprot IDs
A0A384MDW9
O43464
P53778
Q6N076
PDB IDs
1LCY
2PZD
5FHT
5M3N
5M3O
5TNY
5TNZ
5TO0
5TO1
5WYN
1CM8
4QUM
6UNA
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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