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HTRA2 and IMMT
Data Source:
BioGRID
(enzymatic study)
HTRA2
IMMT
Description
HtrA serine peptidase 2
inner membrane mitochondrial protein
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Mitochondrion
Mitochondrial Intermembrane Space
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Cytoskeleton
Cytoplasmic Side Of Plasma Membrane
Membrane
Mitochondrial Membrane
CD40 Receptor Complex
Serine-type Endopeptidase Complex
SAM Complex
Mitochondrion
Mitochondrial Inner Membrane
Mitochondrial Intermembrane Space
Membrane
MICOS Complex
MIB Complex
Molecular Function
Serine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Serine-type Peptidase Activity
Identical Protein Binding
Unfolded Protein Binding
RNA Binding
Protein Binding
Biological Process
Proteolysis
Ceramide Metabolic Process
Mitochondrion Organization
Aging
Adult Walking Behavior
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Herbicide
Positive Regulation Of Mitochondrion Organization
Programmed Cell Death
Protein Autoprocessing
Pentacyclic Triterpenoid Metabolic Process
Forebrain Development
Cellular Response To Oxidative Stress
Cellular Response To Heat
Cellular Response To Interferon-beta
Regulation Of Multicellular Organism Growth
Positive Regulation Of Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Protein Catabolic Process
Negative Regulation Of Cell Cycle
Neuron Development
Cellular Response To Retinoic Acid
Cellular Response To Growth Factor Stimulus
Execution Phase Of Apoptosis
Negative Regulation Of Neuron Death
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Inner Mitochondrial Membrane Organization
Cristae Formation
Mitochondrial Calcium Ion Homeostasis
Pathways
Cristae formation
Drugs
Diseases
Parkinson's disease (PD)
GWAS
Facial emotion recognition (sad faces) (
28608620
)
Night sleep phenotypes (
27126917
)
Interacting Genes
39 interacting genes:
-
ACTA1
ALDH1A2
APC
APP
AREL1
BIRC2
BIRC3
BIRC6
BIRC7
CAD
CCAR2
CDK1
CDK5
CSN1S1
CSN2
DIABLO
EEF1A1
EIF4G1
HSD17B10
IMMT
MAPK11
MAPK12
MAPK13
MAPK14
MAPK3
MUL1
PAG1
PDXDC1
PEA15
TRIM28
TUBA1A
TUBB
TUBB6
TUBB7P
USP7
VIM
VPS4B
XIAP
58 interacting genes:
AKTIP
ALB
ANTKMT
ARMCX3
ASCC2
ATXN1
BAG6
BMI1
C10orf88
C8orf33
CALM1
CCDC113
CCT5
CDC37
CHD3
CSTF2
DISC1
ECSIT
EEF1A1
EP300
EXOSC10
FEZ1
FUBP1
HAP1
HIVEP1
HJURP
HMOX2
HNRNPD
HTRA2
KDM1A
KIF22
KPNA2
LRIF1
MRPL44
NDEL1
NDUFB9
NEK2
NIPSNAP3A
NOS3
PFDN1
PIAS4
PLA2G15
PPOX
PRRC2A
RER1
SDHAF2
SMN1
SNAPIN
SRRT
STMN4
STX5
TAF1D
TK1
TNNT1
TRAF3IP1
TUBGCP3
TXNDC9
UBQLN4
Entrez ID
27429
10989
HPRD ID
05919
02658
Ensembl ID
ENSG00000115317
ENSG00000132305
Uniprot IDs
A0A384MDW9
O43464
Q16891
PDB IDs
1LCY
2PZD
5FHT
5M3N
5M3O
5TNY
5TNZ
5TO0
5TO1
5WYN
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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