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HTRA2 and BIRC6
Data Source:
HPRD
(in vitro, in vivo)
HTRA2
BIRC6
Description
HtrA serine peptidase 2
baculoviral IAP repeat containing 6
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Mitochondrion
Mitochondrial Intermembrane Space
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Cytoskeleton
Cytoplasmic Side Of Plasma Membrane
Membrane
Mitochondrial Membrane
CD40 Receptor Complex
Serine-type Endopeptidase Complex
Spindle Pole
Nucleus
Endosome
Trans-Golgi Network
Microtubule Organizing Center
Membrane
Midbody
Flemming Body
Molecular Function
Serine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Serine-type Peptidase Activity
Identical Protein Binding
Unfolded Protein Binding
Ubiquitin-protein Transferase Activity
Cysteine-type Endopeptidase Inhibitor Activity
Protein Binding
Ubiquitin Conjugating Enzyme Activity
Biological Process
Proteolysis
Ceramide Metabolic Process
Mitochondrion Organization
Aging
Adult Walking Behavior
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Herbicide
Positive Regulation Of Mitochondrion Organization
Programmed Cell Death
Protein Autoprocessing
Pentacyclic Triterpenoid Metabolic Process
Forebrain Development
Cellular Response To Oxidative Stress
Cellular Response To Heat
Cellular Response To Interferon-beta
Regulation Of Multicellular Organism Growth
Positive Regulation Of Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Protein Catabolic Process
Negative Regulation Of Cell Cycle
Neuron Development
Cellular Response To Retinoic Acid
Cellular Response To Growth Factor Stimulus
Execution Phase Of Apoptosis
Negative Regulation Of Neuron Death
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Protein Phosphorylation
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Cell Cycle
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Endopeptidase Activity
Protein Ubiquitination
Regulation Of Cytokinesis
Regulation Of Cell Population Proliferation
Negative Regulation Of Apoptotic Process
Cell Division
Labyrinthine Layer Development
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
Parkinson's disease (PD)
GWAS
Chronotype (
30696823
)
Coffee consumption (
31046077
)
General risk tolerance (MTAG) (
30643258
)
Male-pattern baldness (
28196072
)
Red cell distribution width (
32888494
)
Refractive error (
32231278
)
Risk-taking tendency (4-domain principal component model) (
30643258
)
Interacting Genes
39 interacting genes:
-
ACTA1
ALDH1A2
APC
APP
AREL1
BIRC2
BIRC3
BIRC6
BIRC7
CAD
CCAR2
CDK1
CDK5
CSN1S1
CSN2
DIABLO
EEF1A1
EIF4G1
HSD17B10
IMMT
MAPK11
MAPK12
MAPK13
MAPK14
MAPK3
MUL1
PAG1
PDXDC1
PEA15
TRIM28
TUBA1A
TUBB
TUBB6
TUBB7P
USP7
VIM
VPS4B
XIAP
22 interacting genes:
BIRC5
CASP3
CASP7
CASP8
CASP9
CDK1
CSNK2A1
DIABLO
EXOC3
EXOC4
GABARAP
HTRA2
MAP1LC3B
MAP2K1
PLK1
RAB8A
RACK1
RNF41
UBE2D1
USP8
VAV2
VCL
Entrez ID
27429
57448
HPRD ID
05919
05731
Ensembl ID
ENSG00000115317
ENSG00000115760
Uniprot IDs
A0A384MDW9
O43464
Q9NR09
PDB IDs
1LCY
2PZD
5FHT
5M3N
5M3O
5TNY
5TNZ
5TO0
5TO1
5WYN
3CEG
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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