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HTRA2 and MAPK13
Data Source:
BioGRID
(enzymatic study)
HTRA2
MAPK13
Description
HtrA serine peptidase 2
mitogen-activated protein kinase 13
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Mitochondrion
Mitochondrial Intermembrane Space
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Cytoskeleton
Cytoplasmic Side Of Plasma Membrane
Membrane
Mitochondrial Membrane
CD40 Receptor Complex
Serine-type Endopeptidase Complex
Nucleus
Cytoplasm
Cytosol
Molecular Function
Serine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Serine-type Peptidase Activity
Identical Protein Binding
Unfolded Protein Binding
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
Biological Process
Proteolysis
Ceramide Metabolic Process
Mitochondrion Organization
Aging
Adult Walking Behavior
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Herbicide
Positive Regulation Of Mitochondrion Organization
Programmed Cell Death
Protein Autoprocessing
Pentacyclic Triterpenoid Metabolic Process
Forebrain Development
Cellular Response To Oxidative Stress
Cellular Response To Heat
Cellular Response To Interferon-beta
Regulation Of Multicellular Organism Growth
Positive Regulation Of Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Protein Catabolic Process
Negative Regulation Of Cell Cycle
Neuron Development
Cellular Response To Retinoic Acid
Cellular Response To Growth Factor Stimulus
Execution Phase Of Apoptosis
Negative Regulation Of Neuron Death
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Response To Osmotic Stress
Cell Cycle
Peptidyl-serine Phosphorylation
Positive Regulation Of Interleukin-6 Production
Cellular Response To UV
Intracellular Signal Transduction
Positive Regulation Of Inflammatory Response
Stress-activated MAPK Cascade
Cellular Response To Hydrogen Peroxide
Cellular Response To Interleukin-1
Cellular Response To Sorbitol
Cellular Response To Anisomycin
Cellular Response To Sodium Arsenite
Pathways
NOD1/2 Signaling Pathway
p38MAPK events
DSCAM interactions
VEGFA-VEGFR2 Pathway
Drugs
Minocycline
KC706
Fostamatinib
Diseases
Parkinson's disease (PD)
GWAS
Birth weight (
31043758
)
Blood protein levels (
30072576
29875488
)
Offspring birth weight (
31043758
)
Interacting Genes
39 interacting genes:
-
ACTA1
ALDH1A2
APC
APP
AREL1
BIRC2
BIRC3
BIRC6
BIRC7
CAD
CCAR2
CDK1
CDK5
CSN1S1
CSN2
DIABLO
EEF1A1
EIF4G1
HSD17B10
IMMT
MAPK11
MAPK12
MAPK13
MAPK14
MAPK3
MUL1
PAG1
PDXDC1
PEA15
TRIM28
TUBA1A
TUBB
TUBB6
TUBB7P
USP7
VIM
VPS4B
XIAP
16 interacting genes:
AKIP1
ANKLE2
APP
ATF2
EEF2K
FGF12
GPX4
HTRA2
MAP2K6
MAP3K4
MAPKAPK3
MAPKAPK5
MAPT
MBP
SMAD4
SQSTM1
Entrez ID
27429
5603
HPRD ID
05919
09113
Ensembl ID
ENSG00000115317
ENSG00000156711
Uniprot IDs
A0A384MDW9
O43464
A0A024RD04
O15264
PDB IDs
1LCY
2PZD
5FHT
5M3N
5M3O
5TNY
5TNZ
5TO0
5TO1
5WYN
3COI
4EYJ
4EYM
4MYG
4YNO
5EKN
5EKO
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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