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HTRA2 and BIRC7
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro)
HTRA2
BIRC7
Description
HtrA serine peptidase 2
baculoviral IAP repeat containing 7
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Mitochondrion
Mitochondrial Intermembrane Space
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Cytoskeleton
Cytoplasmic Side Of Plasma Membrane
Membrane
Mitochondrial Membrane
CD40 Receptor Complex
Serine-type Endopeptidase Complex
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Molecular Function
Serine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Serine-type Peptidase Activity
Identical Protein Binding
Unfolded Protein Binding
Ubiquitin-protein Transferase Activity
Cysteine-type Endopeptidase Inhibitor Activity
Protein Binding
Enzyme Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Proteolysis
Ceramide Metabolic Process
Mitochondrion Organization
Aging
Adult Walking Behavior
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Herbicide
Positive Regulation Of Mitochondrion Organization
Programmed Cell Death
Protein Autoprocessing
Pentacyclic Triterpenoid Metabolic Process
Forebrain Development
Cellular Response To Oxidative Stress
Cellular Response To Heat
Cellular Response To Interferon-beta
Regulation Of Multicellular Organism Growth
Positive Regulation Of Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Protein Catabolic Process
Negative Regulation Of Cell Cycle
Neuron Development
Cellular Response To Retinoic Acid
Cellular Response To Growth Factor Stimulus
Execution Phase Of Apoptosis
Negative Regulation Of Neuron Death
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Lens Development In Camera-type Eye
Apoptotic Process
Activation Of JUN Kinase Activity
Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Regulation Of Cell Population Proliferation
Negative Regulation Of Apoptotic Process
Regulation Of Cell Cycle
Regulation Of Natural Killer Cell Apoptotic Process
Pathways
Drugs
Diseases
Parkinson's disease (PD)
GWAS
Interacting Genes
39 interacting genes:
-
ACTA1
ALDH1A2
APC
APP
AREL1
BIRC2
BIRC3
BIRC6
BIRC7
CAD
CCAR2
CDK1
CDK5
CSN1S1
CSN2
DIABLO
EEF1A1
EIF4G1
HSD17B10
IMMT
MAPK11
MAPK12
MAPK13
MAPK14
MAPK3
MUL1
PAG1
PDXDC1
PEA15
TRIM28
TUBA1A
TUBB
TUBB6
TUBB7P
USP7
VIM
VPS4B
XIAP
37 interacting genes:
AURKC
BOLA1
BOLA2
BOLA2B
CASP3
CASP7
CASP9
DDX6
DIABLO
FAM124B
GTF2A1
HTRA2
KANK2
LCOR
LMO4
NTAQ1
PHF1
POLR1C
PRR35
PSMB1
PTCD3
QARS1
SOX5
TEPSIN
TLE5
TNPO2
TSGA10IP
TTPA
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2I
UBE2K
USP2
VPS37C
XAF1
Entrez ID
27429
79444
HPRD ID
05919
05761
Ensembl ID
ENSG00000115317
ENSG00000101197
Uniprot IDs
A0A384MDW9
O43464
Q96CA5
PDB IDs
1LCY
2PZD
5FHT
5M3N
5M3O
5TNY
5TNZ
5TO0
5TO1
5WYN
1OXN
1OXQ
1OY7
1TW6
2I3H
2I3I
3F7G
3F7H
3F7I
3GT9
3GTA
3UW5
4AUQ
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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