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HTRA2 and TUBA1A
Data Source:
BioGRID
(enzymatic study)
HTRA2
TUBA1A
Description
HtrA serine peptidase 2
tubulin alpha 1a
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Mitochondrion
Mitochondrial Intermembrane Space
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Cytoskeleton
Cytoplasmic Side Of Plasma Membrane
Membrane
Mitochondrial Membrane
CD40 Receptor Complex
Serine-type Endopeptidase Complex
Nucleus
Cytoplasm
Cytosol
Microtubule
Cytoplasmic Microtubule
Microtubule Cytoskeleton
Neuromuscular Junction
Cytoplasmic Ribonucleoprotein Granule
Myelin Sheath
Membrane Raft
Recycling Endosome
Extracellular Exosome
Molecular Function
Serine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Serine-type Peptidase Activity
Identical Protein Binding
Unfolded Protein Binding
GTPase Activity
Structural Molecule Activity
Structural Constituent Of Cytoskeleton
Protein Binding
GTP Binding
Protein Domain Specific Binding
Identical Protein Binding
Biological Process
Proteolysis
Ceramide Metabolic Process
Mitochondrion Organization
Aging
Adult Walking Behavior
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Herbicide
Positive Regulation Of Mitochondrion Organization
Programmed Cell Death
Protein Autoprocessing
Pentacyclic Triterpenoid Metabolic Process
Forebrain Development
Cellular Response To Oxidative Stress
Cellular Response To Heat
Cellular Response To Interferon-beta
Regulation Of Multicellular Organism Growth
Positive Regulation Of Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Protein Catabolic Process
Negative Regulation Of Cell Cycle
Neuron Development
Cellular Response To Retinoic Acid
Cellular Response To Growth Factor Stimulus
Execution Phase Of Apoptosis
Negative Regulation Of Neuron Death
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
G2/M Transition Of Mitotic Cell Cycle
Microtubule Cytoskeleton Organization
Mitotic Cell Cycle
Microtubule-based Process
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cytoskeleton-dependent Intracellular Transport
Regulation Of Synapse Organization
Cell Division
Ciliary Basal Body-plasma Membrane Docking
Pathways
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Gap junction assembly
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Prefoldin mediated transfer of substrate to CCT/TriC
Formation of tubulin folding intermediates by CCT/TriC
Post-chaperonin tubulin folding pathway
Recycling pathway of L1
Recycling pathway of L1
Hedgehog 'off' state
Cilium Assembly
Anchoring of the basal body to the plasma membrane
Intraflagellar transport
RHO GTPases activate IQGAPs
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Carboxyterminal post-translational modifications of tubulin
Carboxyterminal post-translational modifications of tubulin
HCMV Early Events
Assembly and cell surface presentation of NMDA receptors
Activation of AMPK downstream of NMDARs
Aggrephagy
Aggrephagy
EML4 and NUDC in mitotic spindle formation
Sealing of the nuclear envelope (NE) by ESCRT-III
Kinesins
Drugs
Albendazole
Vinblastine
Mebendazole
Epothilone D
Patupilone
CYT997
2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Artenimol
Phenethyl Isothiocyanate
Colchiceine
Diseases
Parkinson's disease (PD)
Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS
Brain morphology (MOSTest) (
32665545
)
Composite immunoglobulin trait (IgG/IgM) (
28628107
)
Interacting Genes
39 interacting genes:
-
ACTA1
ALDH1A2
APC
APP
AREL1
BIRC2
BIRC3
BIRC6
BIRC7
CAD
CCAR2
CDK1
CDK5
CSN1S1
CSN2
DIABLO
EEF1A1
EIF4G1
HSD17B10
IMMT
MAPK11
MAPK12
MAPK13
MAPK14
MAPK3
MUL1
PAG1
PDXDC1
PEA15
TRIM28
TUBA1A
TUBB
TUBB6
TUBB7P
USP7
VIM
VPS4B
XIAP
63 interacting genes:
ANXA7
ARL3
ATXN3
B4GALT1
BTG1
C8orf33
CDKN1A
CDKN2A
CEP20
CLIP1
CNP
CPEB2
CXCR1
CYLD
DAG1
DUSP23
EGFR
EML1
GEMIN7
GRM7
GSK3B
GZMB
HDAC6
HTRA2
KEL
KPNB1
LINC01554
LRRK2
MAP2
MAP7D3
MAPK6
MAPRE1
MAX
MX1
MYC
NFATC1
NUDT3
PAFAH1B1
PLA2G7
S100A8
S100A9
SDC3
SIAH1
SMN1
SNCA
SOCS6
SOCS7
SPART
STARD13
STK11
SYK
TAOK2
TBCB
TIMM17A
TK1
TLN1
TTR
TUBB
UBE2D3
VAV1
VCL
YWHAQ
ZAP70
Entrez ID
27429
7846
HPRD ID
05919
03959
Ensembl ID
ENSG00000115317
ENSG00000167552
Uniprot IDs
A0A384MDW9
O43464
Q71U36
PDB IDs
1LCY
2PZD
5FHT
5M3N
5M3O
5TNY
5TNZ
5TO0
5TO1
5WYN
5JCO
6J8F
6WSL
7C1M
Enriched GO Terms of Interacting Partners
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