HTRA2 and AREL1

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		HTRA2	AREL1
Description		HtrA serine peptidase 2	apoptosis resistant E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Chromatin Nucleus Mitochondrion Mitochondrial Intermembrane Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Cytoplasmic Side Of Plasma Membrane Membrane Mitochondrial Membrane CD40 Receptor Complex Serine-type Endopeptidase Complex	Cytoplasm Cytosol
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Identical Protein Binding Unfolded Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Proteolysis Ceramide Metabolic Process Mitochondrion Organization Aging Adult Walking Behavior Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Herbicide Positive Regulation Of Mitochondrion Organization Programmed Cell Death Protein Autoprocessing Pentacyclic Triterpenoid Metabolic Process Forebrain Development Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Interferon-beta Regulation Of Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Protein Catabolic Process Negative Regulation Of Cell Cycle Neuron Development Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Execution Phase Of Apoptosis Negative Regulation Of Neuron Death Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Mitophagy In Response To Mitochondrial Depolarization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Inflammatory Response
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Parkinson's disease (PD)
GWAS			General factor of neuroticism ( 30867560) Mood instability ( 29187730)
Interacting Genes		39 interacting genes: - ACTA1 ALDH1A2 APC APP AREL1 BIRC2 BIRC3 BIRC6 BIRC7 CAD CCAR2 CDK1 CDK5 CSN1S1 CSN2 DIABLO EEF1A1 EIF4G1 HSD17B10 IMMT MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MUL1 PAG1 PDXDC1 PEA15 TRIM28 TUBA1A TUBB TUBB6 TUBB7P USP7 VIM VPS4B XIAP	10 interacting genes: CRKL DIABLO HTRA2 PIAS4 SEPTIN4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3
Entrez ID		27429	9870
HPRD ID		05919	13794
Ensembl ID		ENSG00000115317	ENSG00000119682
Uniprot IDs		A0A384MDW9 O43464	O15033
PDB IDs		1LCY 2PZD 5FHT 5M3N 5M3O 5TNY 5TNZ 5TO0 5TO1 5WYN	6JX5
Enriched GO Terms of Interacting Partners?
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