TARBP2 and NF2

Data Source:
HPRD (in vitro, in vivo)

		TARBP2	NF2
Description		TARBP2 subunit of RISC loading complex	neurofibromin 2
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol RISC Complex Nuclear Body Perinuclear Region Of Cytoplasm RISC-loading Complex	Nucleus Nucleolus Cytoplasm Early Endosome Cytosol Cytoskeleton Plasma Membrane Adherens Junction Membrane Lamellipodium Cortical Actin Cytoskeleton Filopodium Membrane Cleavage Furrow Ruffle Membrane Neuron Projection Cell Body Apical Part Of Cell Perinuclear Region Of Cytoplasm
	Molecular Function	Double-stranded RNA Binding Protein Binding Enzyme Binding SiRNA Binding MiRNA Binding Pre-mRNA Binding Identical Protein Binding Protein Homodimerization Activity Protein N-terminus Binding Pre-miRNA Binding	Actin Binding Protein Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Spermatid Development Single Fertilization MiRNA Metabolic Process Production Of SiRNA Involved In RNA Interference Targeting Of MRNA For Destruction Involved In RNA Interference Pre-miRNA Processing SiRNA Loading Onto RISC Involved In RNA Interference Production Of MiRNAs Involved In Gene Silencing By MiRNA Multicellular Organism Growth MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Skeletal Muscle Tissue Regeneration Positive Regulation Of Viral Genome Replication Positive Regulation Of Translation Regulation Of Viral Transcription Negative Regulation Of Defense Response To Virus By Host Positive Regulation Of Muscle Cell Differentiation Neural Precursor Cell Proliferation Regulation Of Production Of SiRNA Involved In RNA Interference Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA	Mesoderm Formation Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Kinase Activity Ectoderm Development Negative Regulation Of Cell Population Proliferation Schwann Cell Proliferation Regulation Of Gliogenesis Hippocampus Development Negative Regulation Of Cell-cell Adhesion Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Regulation Of Protein Stability Regulation Of Hippo Signaling Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Cell-cell Junction Organization Positive Regulation Of Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Lens Fiber Cell Differentiation Regulation Of Stem Cell Proliferation Regulation Of Protein Localization To Nucleus Regulation Of Neural Precursor Cell Proliferation
Pathways		MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis	Regulation of actin dynamics for phagocytic cup formation RHO GTPases activate PAKs
Drugs
Diseases			Malignant pleural mesothelioma Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Carotid atherosclerosis in HIV infection ( 20009918)
Interacting Genes		27 interacting genes: ADARB1 AGO2 APP DICER1 EIF2AK2 HDHD2 HSPB1 IKBKG KCNIP3 MAPK8IP2 MED21 NEDD4L NEUROG1 NF2 NUDT18 PNKP PRKRA RBM14 TCEA2 TCEANC TGIF2 TOP1 TRAF4 VAV2 ZMAT3 ZMAT4 ZNF346	74 interacting genes: AGAP2 AKT1 AMOT AMOTL2 ARAF ARNT AURKA BDKRB1 BECN1 BYSL CBLC CCNB1IP1 CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2B CDKN2C CTNNB1 DACH1 DCAF1 EGFR EIF3B EMD EPHA2 ERBB2 EZR FGFR4 FZR1 GLIS2 GRM1 HGF HGS HIF1A IGF1R ITGB1 KAT2A KDELR2 KDM1A LATS1 LATS2 MAP2K3 MAP2K5 MAP3K5 MAPK14 MDM4 MED28 MET MYBPC2 MYC PAK1 PDGFRA PRKCA PXN PYGO2 RAF1 RALGDS RASSF1 SCHIP1 SDCBP SGSM3 SLC9A3R1 SOX3 SOX4 SPTBN1 STK11 TARBP2 TERT TP53 TSC1 TTYH2 TXLNB XPO1
Entrez ID		6895	4771
HPRD ID		05446	06980
Ensembl ID		ENSG00000139546	ENSG00000186575
Uniprot IDs		A0A024RB49 Q15633	A0A024R1D9 A0A024R1F6 A0A024R1I0 A0A024R1J8 A0A024R1J9 P35240
PDB IDs		2CPN 3ADL 3LLH 4WYQ 5N8L 5N8M 5ZAK 5ZAL 5ZAM	1H4R 3U8Z 4ZRI 4ZRJ 6CDS
Enriched GO Terms of Interacting Partners?
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