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NF2 and MAP3K5
Data Source:
BioGRID
(fluorescent resonance energy transfer)
NF2
MAP3K5
Description
neurofibromin 2
mitogen-activated protein kinase kinase kinase 5
Image
GO Annotations
Cellular Component
Nucleus
Nucleolus
Cytoplasm
Early Endosome
Cytosol
Cytoskeleton
Plasma Membrane
Adherens Junction
Membrane
Lamellipodium
Cortical Actin Cytoskeleton
Filopodium Membrane
Cleavage Furrow
Ruffle Membrane
Neuron Projection
Cell Body
Apical Part Of Cell
Perinuclear Region Of Cytoplasm
Cytoplasm
Cytosol
External Side Of Plasma Membrane
Protein-containing Complex
Protein Kinase Complex
IRE1-TRAF2-ASK1 Complex
Molecular Function
Actin Binding
Protein Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Protein Phosphatase Binding
Protein Domain Specific Binding
Identical Protein Binding
Protein Homodimerization Activity
Biological Process
Mesoderm Formation
Negative Regulation Of Cell-matrix Adhesion
Negative Regulation Of Protein Kinase Activity
Ectoderm Development
Negative Regulation Of Cell Population Proliferation
Schwann Cell Proliferation
Regulation Of Gliogenesis
Hippocampus Development
Negative Regulation Of Cell-cell Adhesion
Actin Cytoskeleton Organization
Negative Regulation Of Cell Migration
Regulation Of Protein Stability
Regulation Of Hippo Signaling
Odontogenesis Of Dentin-containing Tooth
Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein
Regulation Of Apoptotic Process
Negative Regulation Of MAPK Cascade
Cell-cell Junction Organization
Positive Regulation Of Cell Differentiation
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Stress Fiber Assembly
Regulation Of Cell Cycle
Lens Fiber Cell Differentiation
Regulation Of Stem Cell Proliferation
Regulation Of Protein Localization To Nucleus
Regulation Of Neural Precursor Cell Proliferation
MAPK Cascade
Activation Of MAPKK Activity
Response To Ischemia
Protein Phosphorylation
JNK Cascade
Activation Of JUN Kinase Activity
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Positive Regulation Of Cardiac Muscle Cell Apoptotic Process
Viral Process
Cellular Response To Stress
Cellular Response To Amino Acid Starvation
Response To Endoplasmic Reticulum Stress
P38MAPK Cascade
Wound Healing
Positive Regulation Of Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of JUN Kinase Activity
Innate Immune Response
Positive Regulation Of Myoblast Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of JNK Cascade
Stress-activated MAPK Cascade
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Cellular Response To Hydrogen Peroxide
Cellular Response To Tumor Necrosis Factor
Endothelial Cell Apoptotic Process
Apoptotic Signaling Pathway
Programmed Necrotic Cell Death
Positive Regulation Of P38MAPK Cascade
Positive Regulation Of Neuron Death
Cellular Response To Reactive Nitrogen Species
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways
Regulation of actin dynamics for phagocytic cup formation
RHO GTPases activate PAKs
Oxidative Stress Induced Senescence
Oxidative Stress Induced Senescence
Drugs
Diseases
Malignant pleural mesothelioma
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Carotid atherosclerosis in HIV infection (
20009918
)
Eosinophil counts (
32888494
)
HDL cholesterol (
30275531
)
HDL cholesterol levels (
32203549
)
Immature fraction of reticulocytes (
32888494
)
Neutrophil count (
32888494
)
White blood cell count (
32888494
)
Interacting Genes
74 interacting genes:
AGAP2
AKT1
AMOT
AMOTL2
ARAF
ARNT
AURKA
BDKRB1
BECN1
BYSL
CBLC
CCNB1IP1
CCND2
CCNE1
CD44
CDK4
CDK6
CDKN2B
CDKN2C
CTNNB1
DACH1
DCAF1
EGFR
EIF3B
EMD
EPHA2
ERBB2
EZR
FGFR4
FZR1
GLIS2
GRM1
HGF
HGS
HIF1A
IGF1R
ITGB1
KAT2A
KDELR2
KDM1A
LATS1
LATS2
MAP2K3
MAP2K5
MAP3K5
MAPK14
MDM4
MED28
MET
MYBPC2
MYC
PAK1
PDGFRA
PRKCA
PXN
PYGO2
RAF1
RALGDS
RASSF1
SCHIP1
SDCBP
SGSM3
SLC9A3R1
SOX3
SOX4
SPTBN1
STK11
TARBP2
TERT
TP53
TSC1
TTYH2
TXLNB
XPO1
64 interacting genes:
AKT1
ARRB1
ARRB2
AURKA
CCND2
CDC25A
CDK4
CDK6
CDKN1A
CDKN2A
CREBBP
DAB2IP
DAXX
DMD
DUSP19
EIF2AK2
EP300
ERN1
FGFR4
FZR1
GADD45B
GEMIN5
GLIS2
GLRX
GSTM1
HSPA1A
IGF1R
JAK2
MAP2K4
MAP2K6
MAP2K7
MAP3K2
MAP3K3
MAP3K6
MAP3K7
MAPK8IP3
MBP
NEDD4
NEDD4L
NF2
PDCD6
PPP3R1
PPP5C
PTPN11
QARS1
RAF1
SFN
SIAH1
STK11
TEAD2
TERT
TNFAIP3
TNNT2
TPD52L1
TRAF2
TRAF5
TRAF6
TULP3
TXN
USP9X
YWHAE
YWHAH
YWHAQ
YWHAZ
Entrez ID
4771
4217
HPRD ID
06980
03904
Ensembl ID
ENSG00000186575
ENSG00000197442
Uniprot IDs
A0A024R1D9
A0A024R1F6
A0A024R1I0
A0A024R1J8
A0A024R1J9
P35240
Q99683
PDB IDs
1H4R
3U8Z
4ZRI
4ZRJ
6CDS
2CLQ
3VW6
4BF2
4BHN
4BIB
4BIC
4BID
4BIE
5ULM
5UOR
5UOX
5UP3
5V19
5V24
5VIL
5VIO
6E2M
6E2N
6E2O
6EJL
6OYT
6OYW
6VRE
6XIH
Enriched GO Terms of Interacting Partners
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