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NF2 and AMOTL2
Data Source:
BioGRID
(two hybrid)
NF2
AMOTL2
Description
neurofibromin 2
angiomotin like 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleolus
Cytoplasm
Early Endosome
Cytosol
Cytoskeleton
Plasma Membrane
Adherens Junction
Membrane
Lamellipodium
Cortical Actin Cytoskeleton
Filopodium Membrane
Cleavage Furrow
Ruffle Membrane
Neuron Projection
Cell Body
Apical Part Of Cell
Perinuclear Region Of Cytoplasm
Cytosol
Plasma Membrane
Bicellular Tight Junction
Cytoplasmic Vesicle
Recycling Endosome
Molecular Function
Actin Binding
Protein Binding
Protein Binding
Biological Process
Mesoderm Formation
Negative Regulation Of Cell-matrix Adhesion
Negative Regulation Of Protein Kinase Activity
Ectoderm Development
Negative Regulation Of Cell Population Proliferation
Schwann Cell Proliferation
Regulation Of Gliogenesis
Hippocampus Development
Negative Regulation Of Cell-cell Adhesion
Actin Cytoskeleton Organization
Negative Regulation Of Cell Migration
Regulation Of Protein Stability
Regulation Of Hippo Signaling
Odontogenesis Of Dentin-containing Tooth
Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein
Regulation Of Apoptotic Process
Negative Regulation Of MAPK Cascade
Cell-cell Junction Organization
Positive Regulation Of Cell Differentiation
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Stress Fiber Assembly
Regulation Of Cell Cycle
Lens Fiber Cell Differentiation
Regulation Of Stem Cell Proliferation
Regulation Of Protein Localization To Nucleus
Regulation Of Neural Precursor Cell Proliferation
Angiogenesis
Establishment Of Cell Polarity Involved In Ameboidal Cell Migration
Wnt Signaling Pathway
Actin Cytoskeleton Organization
Regulation Of Cell Migration
Hippo Signaling
Pathways
Regulation of actin dynamics for phagocytic cup formation
RHO GTPases activate PAKs
Signaling by Hippo
Drugs
Diseases
Malignant pleural mesothelioma
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Carotid atherosclerosis in HIV infection (
20009918
)
Cadmium levels (
26025379
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Vertical cup-disc ratio (adjusted for vertical disc diameter) (
31959993
)
Interacting Genes
74 interacting genes:
AGAP2
AKT1
AMOT
AMOTL2
ARAF
ARNT
AURKA
BDKRB1
BECN1
BYSL
CBLC
CCNB1IP1
CCND2
CCNE1
CD44
CDK4
CDK6
CDKN2B
CDKN2C
CTNNB1
DACH1
DCAF1
EGFR
EIF3B
EMD
EPHA2
ERBB2
EZR
FGFR4
FZR1
GLIS2
GRM1
HGF
HGS
HIF1A
IGF1R
ITGB1
KAT2A
KDELR2
KDM1A
LATS1
LATS2
MAP2K3
MAP2K5
MAP3K5
MAPK14
MDM4
MED28
MET
MYBPC2
MYC
PAK1
PDGFRA
PRKCA
PXN
PYGO2
RAF1
RALGDS
RASSF1
SCHIP1
SDCBP
SGSM3
SLC9A3R1
SOX3
SOX4
SPTBN1
STK11
TARBP2
TERT
TP53
TSC1
TTYH2
TXLNB
XPO1
91 interacting genes:
AMOT
BFSP2
BLZF1
BRMS1L
BYSL
CARD9
CCDC185
CCDC196
CCDC57
CCHCR1
CDC37
CDR2
CHCHD3
CINP
CYTH4
DAXX
DDIT3
DTNB
DYNLL1
DZIP1L
EIF4E2
FAM184A
FAM90A1
FBXO7
FCRL5
FXR2
GCC1
GNG11
GNG5
GOLGA2
GSTM5
KIF9
KRT1
KRT13
KRT15
KRT19
KRT20
KRT31
KRT38
KRTAP10-5
KRTAP4-2
L3MBTL2
LMNB2
LMO3
LMO4
MAD1L1
MAGEA4
MAGOHB
MFAP1
MORF4L2
MPP1
MTMR6
MTNR1A
MYO5B
NDC80
NF2
NFIL3
NME7
NTAQ1
PIBF1
PPP2CA
PPP2R1A
PRKAA2
PRPF18
PSMC3
RAD51D
RALBP1
RASAL3
RASSF5
RNF20
RNF40
RNF8
SAAL1
SH3RF2
SMARCE1
SOGA1
SP100
SPAG5
SPOP
SPP1
TCEA2
THRA
TMCC2
TNKS2
TRAF2
TRIM27
TSGA10IP
YES1
ZBED1
ZBTB16
ZGPAT
Entrez ID
4771
51421
HPRD ID
06980
16485
Ensembl ID
ENSG00000186575
ENSG00000114019
Uniprot IDs
A0A024R1D9
A0A024R1F6
A0A024R1I0
A0A024R1J8
A0A024R1J9
P35240
Q9Y2J4
PDB IDs
1H4R
3U8Z
4ZRI
4ZRJ
6CDS
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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