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NF2 and SOX4
Data Source:
BioGRID
(fluorescent resonance energy transfer)
NF2
SOX4
Description
neurofibromin 2
SRY-box transcription factor 4
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleolus
Cytoplasm
Early Endosome
Cytosol
Cytoskeleton
Plasma Membrane
Adherens Junction
Membrane
Lamellipodium
Cortical Actin Cytoskeleton
Filopodium Membrane
Cleavage Furrow
Ruffle Membrane
Neuron Projection
Cell Body
Apical Part Of Cell
Perinuclear Region Of Cytoplasm
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Mitochondrion
Molecular Function
Actin Binding
Protein Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
MiRNA Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Mesoderm Formation
Negative Regulation Of Cell-matrix Adhesion
Negative Regulation Of Protein Kinase Activity
Ectoderm Development
Negative Regulation Of Cell Population Proliferation
Schwann Cell Proliferation
Regulation Of Gliogenesis
Hippocampus Development
Negative Regulation Of Cell-cell Adhesion
Actin Cytoskeleton Organization
Negative Regulation Of Cell Migration
Regulation Of Protein Stability
Regulation Of Hippo Signaling
Odontogenesis Of Dentin-containing Tooth
Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein
Regulation Of Apoptotic Process
Negative Regulation Of MAPK Cascade
Cell-cell Junction Organization
Positive Regulation Of Cell Differentiation
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Stress Fiber Assembly
Regulation Of Cell Cycle
Lens Fiber Cell Differentiation
Regulation Of Stem Cell Proliferation
Regulation Of Protein Localization To Nucleus
Regulation Of Neural Precursor Cell Proliferation
Skeletal System Development
Neural Tube Formation
Pro-B Cell Differentiation
Mitral Valve Morphogenesis
Cardiac Ventricle Formation
Cardiac Right Ventricle Morphogenesis
Atrial Septum Primum Morphogenesis
Noradrenergic Neuron Differentiation
Regulation Of Transcription, DNA-templated
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Heart Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Anatomical Structure Morphogenesis
Glial Cell Proliferation
Spinal Cord Development
Spinal Cord Motor Neuron Differentiation
Glial Cell Development
Cell Differentiation
T Cell Differentiation
Endocrine Pancreas Development
Negative Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Positive Regulation Of Insulin Secretion
Somatic Stem Cell Population Maintenance
Ascending Aorta Morphogenesis
Glucose Homeostasis
DNA Damage Response, Detection Of DNA Damage
Positive Regulation Of Apoptotic Process
Positive Regulation Of Gamma-delta T Cell Differentiation
Positive Regulation Of Translation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Sympathetic Nervous System Development
Protein Stabilization
Limb Bud Formation
Ventricular Septum Morphogenesis
Negative Regulation Of Cell Death
Neuroepithelial Cell Differentiation
Kidney Morphogenesis
Hematopoietic Stem Cell Homeostasis
Cellular Response To Glucose Stimulus
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of N-terminal Peptidyl-lysine Acetylation
Pathways
Regulation of actin dynamics for phagocytic cup formation
RHO GTPases activate PAKs
Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
Malignant pleural mesothelioma
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Carotid atherosclerosis in HIV infection (
20009918
)
Bone mineral density (
21533022
)
Cardiac hypertrophy (
21348951
)
Endometrial cancer (
30093612
27008869
)
Endometrial cancer (endometrioid histology) (
30093612
)
Metabolite levels (
23823483
)
Pulmonary function (smoking interaction) (
23284291
)
Interacting Genes
74 interacting genes:
AGAP2
AKT1
AMOT
AMOTL2
ARAF
ARNT
AURKA
BDKRB1
BECN1
BYSL
CBLC
CCNB1IP1
CCND2
CCNE1
CD44
CDK4
CDK6
CDKN2B
CDKN2C
CTNNB1
DACH1
DCAF1
EGFR
EIF3B
EMD
EPHA2
ERBB2
EZR
FGFR4
FZR1
GLIS2
GRM1
HGF
HGS
HIF1A
IGF1R
ITGB1
KAT2A
KDELR2
KDM1A
LATS1
LATS2
MAP2K3
MAP2K5
MAP3K5
MAPK14
MDM4
MED28
MET
MYBPC2
MYC
PAK1
PDGFRA
PRKCA
PXN
PYGO2
RAF1
RALGDS
RASSF1
SCHIP1
SDCBP
SGSM3
SLC9A3R1
SOX3
SOX4
SPTBN1
STK11
TARBP2
TERT
TP53
TSC1
TTYH2
TXLNB
XPO1
34 interacting genes:
AKT1
APOC3
AURKA
CAPN15
CDKN2A
CTR9
DACH1
EDF1
FOXH1
FZR1
IGF1
ITIH1
KRAS
MINPP1
MNT
MYC
NANOGNB
NF1
NF2
NSD3
PLD3
PLXNB1
RGSL1
RHOU
RP1L1
SCNN1G
SDCBP
SMARCA4
STK11
TERT
TNNI3
TSC1
UBE2I
WT1
Entrez ID
4771
6659
HPRD ID
06980
01695
Ensembl ID
ENSG00000186575
ENSG00000124766
Uniprot IDs
A0A024R1D9
A0A024R1F6
A0A024R1I0
A0A024R1J8
A0A024R1J9
P35240
Q06945
PDB IDs
1H4R
3U8Z
4ZRI
4ZRJ
6CDS
Enriched GO Terms of Interacting Partners
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