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NF2 and BYSL
Data Source:
BioGRID
(two hybrid)
NF2
BYSL
Description
neurofibromin 2
bystin like
Image
GO Annotations
Cellular Component
Nucleus
Nucleolus
Cytoplasm
Early Endosome
Cytosol
Cytoskeleton
Plasma Membrane
Adherens Junction
Membrane
Lamellipodium
Cortical Actin Cytoskeleton
Filopodium Membrane
Cleavage Furrow
Ruffle Membrane
Neuron Projection
Cell Body
Apical Part Of Cell
Perinuclear Region Of Cytoplasm
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Cytosol
Membrane
Preribosome, Small Subunit Precursor
Intracellular Membrane-bounded Organelle
Apical Part Of Cell
Molecular Function
Actin Binding
Protein Binding
RNA Binding
Protein Binding
SnoRNA Binding
Biological Process
Mesoderm Formation
Negative Regulation Of Cell-matrix Adhesion
Negative Regulation Of Protein Kinase Activity
Ectoderm Development
Negative Regulation Of Cell Population Proliferation
Schwann Cell Proliferation
Regulation Of Gliogenesis
Hippocampus Development
Negative Regulation Of Cell-cell Adhesion
Actin Cytoskeleton Organization
Negative Regulation Of Cell Migration
Regulation Of Protein Stability
Regulation Of Hippo Signaling
Odontogenesis Of Dentin-containing Tooth
Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein
Regulation Of Apoptotic Process
Negative Regulation Of MAPK Cascade
Cell-cell Junction Organization
Positive Regulation Of Cell Differentiation
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Stress Fiber Assembly
Regulation Of Cell Cycle
Lens Fiber Cell Differentiation
Regulation Of Stem Cell Proliferation
Regulation Of Protein Localization To Nucleus
Regulation Of Neural Precursor Cell Proliferation
Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
Trophectodermal Cell Differentiation
RRNA Processing
Cell Population Proliferation
Ribosome Biogenesis
Regulation Of Protein Localization To Nucleolus
Pathways
Regulation of actin dynamics for phagocytic cup formation
RHO GTPases activate PAKs
Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
Malignant pleural mesothelioma
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Carotid atherosclerosis in HIV infection (
20009918
)
Hematological parameters (
19820697
)
Mean corpuscular hemoglobin (
20139978
19862010
)
Mean corpuscular volume (
23263863
20139978
19862010
)
Menarche (age at onset) (
27182965
25231870
)
Metabolite levels (
23823483
)
Monocyte percentage of white cells (
32888494
)
Red blood cell count (
20139978
)
Interacting Genes
74 interacting genes:
AGAP2
AKT1
AMOT
AMOTL2
ARAF
ARNT
AURKA
BDKRB1
BECN1
BYSL
CBLC
CCNB1IP1
CCND2
CCNE1
CD44
CDK4
CDK6
CDKN2B
CDKN2C
CTNNB1
DACH1
DCAF1
EGFR
EIF3B
EMD
EPHA2
ERBB2
EZR
FGFR4
FZR1
GLIS2
GRM1
HGF
HGS
HIF1A
IGF1R
ITGB1
KAT2A
KDELR2
KDM1A
LATS1
LATS2
MAP2K3
MAP2K5
MAP3K5
MAPK14
MDM4
MED28
MET
MYBPC2
MYC
PAK1
PDGFRA
PRKCA
PXN
PYGO2
RAF1
RALGDS
RASSF1
SCHIP1
SDCBP
SGSM3
SLC9A3R1
SOX3
SOX4
SPTBN1
STK11
TARBP2
TERT
TP53
TSC1
TTYH2
TXLNB
XPO1
139 interacting genes:
AIMP2
AMOTL2
APP
ATP5F1B
AXIN2
BEND7
BFSP1
BHLHE40
C1orf94
CAVIN4
CCDC102B
CCDC136
CCDC33
CDC23
CDCA7L
CEP44
CEP57L1
CEP70
COIL
DDX17
DOCK8
DVL2
EAPP
EMD
EPS8
FAM228A
FAM9B
FCHO1
FXR1
FXR2
GAS8
GMCL1
GOLGA2
GOLGA6L9
GRIPAP1
HMBOX1
HOMEZ
HOOK2
HSF2BP
IKZF1
IKZF3
JRK
KATNAL1
KIFC3
KLHL2
KLHL6
KRT31
KRT40
KRT8
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP4-2
L3MBTL3
LDOC1
LHX3
LMNA
LMO1
LMO2
LONRF1
LTV1
LZTS1
LZTS2
MB21D2
MCIDAS
MEOX1
MEOX2
MID1
MID2
MIPOL1
MKRN1
MRFAP1L1
MTUS2
NECAB2
NF2
OLIG3
OSBPL3
PDE4DIP
PHC2
PICK1
PIH1D1
PNMA1
PNMA2
PRICKLE1
PSMC6
RACGAP1
RACK1
RALY
RALYL
RBAK
RP9
RUBCN
SMN1
SMN2
SNW1
SSX2IP
STX11
TBC1D26
TEKT1
TFIP11
THAP1
TLE5
TNIP1
TRAF2
TRAF4
TRAK1
TRIM14
TRIM27
TRIM37
TRIM38
TRIM41
TRIM54
TRIM55
TRIP6
TRO
TROAP
UBE2H
USH1G
VIM
VPS37B
VPS52
WASF3
WTAP
ZBTB14
ZBTB8A
ZC2HC1C
ZFP64
ZMAT5
ZNF212
ZNF286A
ZNF426
ZNF438
ZNF48
ZNF655
ZNF668
ZNF71
ZNF835
ZRANB1
ZSCAN22
Entrez ID
4771
705
HPRD ID
06980
04848
Ensembl ID
ENSG00000186575
ENSG00000112578
Uniprot IDs
A0A024R1D9
A0A024R1F6
A0A024R1I0
A0A024R1J8
A0A024R1J9
P35240
Q13895
PDB IDs
1H4R
3U8Z
4ZRI
4ZRJ
6CDS
6G18
6G4S
6G4W
Enriched GO Terms of Interacting Partners
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