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NF2 and ARNT
Data Source:
BioGRID
(fluorescent resonance energy transfer)
NF2
ARNT
Description
neurofibromin 2
aryl hydrocarbon receptor nuclear translocator
Image
GO Annotations
Cellular Component
Nucleus
Nucleolus
Cytoplasm
Early Endosome
Cytosol
Cytoskeleton
Plasma Membrane
Adherens Junction
Membrane
Lamellipodium
Cortical Actin Cytoskeleton
Filopodium Membrane
Cleavage Furrow
Ruffle Membrane
Neuron Projection
Cell Body
Apical Part Of Cell
Perinuclear Region Of Cytoplasm
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Body
Aryl Hydrocarbon Receptor Complex
RNA Polymerase II Transcription Regulator Complex
Molecular Function
Actin Binding
Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Transcription Factor Binding
Aryl Hydrocarbon Receptor Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Protein Heterodimerization Activity
Sequence-specific Double-stranded DNA Binding
Biological Process
Mesoderm Formation
Negative Regulation Of Cell-matrix Adhesion
Negative Regulation Of Protein Kinase Activity
Ectoderm Development
Negative Regulation Of Cell Population Proliferation
Schwann Cell Proliferation
Regulation Of Gliogenesis
Hippocampus Development
Negative Regulation Of Cell-cell Adhesion
Actin Cytoskeleton Organization
Negative Regulation Of Cell Migration
Regulation Of Protein Stability
Regulation Of Hippo Signaling
Odontogenesis Of Dentin-containing Tooth
Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein
Regulation Of Apoptotic Process
Negative Regulation Of MAPK Cascade
Cell-cell Junction Organization
Positive Regulation Of Cell Differentiation
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Stress Fiber Assembly
Regulation Of Cell Cycle
Lens Fiber Cell Differentiation
Regulation Of Stem Cell Proliferation
Regulation Of Protein Localization To Nucleus
Regulation Of Neural Precursor Cell Proliferation
Response To Hypoxia
Embryonic Placenta Development
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of Transcription By RNA Polymerase II
Xenobiotic Metabolic Process
Positive Regulation Of Vascular Endothelial Growth Factor Production
Cell Differentiation
Intracellular Receptor Signaling Pathway
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Protein Sumoylation
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Glycolytic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Hormone Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Pathways
Regulation of actin dynamics for phagocytic cup formation
RHO GTPases activate PAKs
Regulation of gene expression by Hypoxia-inducible Factor
PPARA activates gene expression
Phase I - Functionalization of compounds
Endogenous sterols
Xenobiotics
Aryl hydrocarbon receptor signalling
Drugs
Diseases
Malignant pleural mesothelioma
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Carotid atherosclerosis in HIV infection (
20009918
)
Blood protein levels (
28240269
)
Body mass index (
26426971
)
Congenital left-sided heart lesions (
26965164
)
Cutaneous squamous cell carcinoma (
32041948
)
Estimated glomerular filtration rate (
31451708
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Melanoma (
21983785
28212542
)
Metabolic syndrome (
31589552
)
Platelet count (
32888494
)
Rhegmatogenous retinal detachment (
23585552
)
Tea consumption (
31046077
)
Urate levels (
23263486
)
Interacting Genes
74 interacting genes:
AGAP2
AKT1
AMOT
AMOTL2
ARAF
ARNT
AURKA
BDKRB1
BECN1
BYSL
CBLC
CCNB1IP1
CCND2
CCNE1
CD44
CDK4
CDK6
CDKN2B
CDKN2C
CTNNB1
DACH1
DCAF1
EGFR
EIF3B
EMD
EPHA2
ERBB2
EZR
FGFR4
FZR1
GLIS2
GRM1
HGF
HGS
HIF1A
IGF1R
ITGB1
KAT2A
KDELR2
KDM1A
LATS1
LATS2
MAP2K3
MAP2K5
MAP3K5
MAPK14
MDM4
MED28
MET
MYBPC2
MYC
PAK1
PDGFRA
PRKCA
PXN
PYGO2
RAF1
RALGDS
RASSF1
SCHIP1
SDCBP
SGSM3
SLC9A3R1
SOX3
SOX4
SPTBN1
STK11
TARBP2
TERT
TP53
TSC1
TTYH2
TXLNB
XPO1
77 interacting genes:
ADH5
AHR
AHRR
AIP
AKT1
ARL14
ARNT2
BECN1
BRCA1
CALCOCO1
CASP3
CASP9
CCND2
CCNE1
CD44
CDK4
CDK6
CDKN2A
CDKN2B
CDKN2C
CSNK2A1
DIABLO
EP300
EPAS1
EPHA2
ERBB2
ESR1
FGFR4
FZR1
GLIS1
GLIS2
GMNN
GTF2F1
GTF2F2
HEY1
HEY2
HGF
HIF1A
HIF3A
HNF4A
IRAK4
KPNA1
KPNA3
KPNA5
KPNA6
LATS2
LSM8
MAP2K5
MAPK14
MTA3
MYC
NCOA1
NCOA2
NCOA7
NCOR2
NF2
NPAS4
PDGFRA
PML
PTGES3
RAF1
RELA
SENP6
SIM1
SIM2
SMAD9
SP1
STK11
STRBP
TACC3
TEAD2
TGM2
TNFAIP1
TP53
TRIP11
TUBB2A
UBE2I
Entrez ID
4771
405
HPRD ID
06980
00524
Ensembl ID
ENSG00000186575
ENSG00000143437
Uniprot IDs
A0A024R1D9
A0A024R1F6
A0A024R1I0
A0A024R1J8
A0A024R1J9
P35240
A8K6P0
B0AZM1
P27540
Q53F30
PDB IDs
1H4R
3U8Z
4ZRI
4ZRJ
6CDS
1D7G
1X0O
2A24
2ARN
2B02
2HV1
2K7S
3F1N
3F1O
3F1P
3H7W
3H82
4EQ1
4GHI
4GS9
4H6J
4LPZ
4PKY
4XT2
5TBM
5UFP
5V0L
6CZW
6D09
6D0B
6D0C
Enriched GO Terms of Interacting Partners
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