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NF2 and AGAP2
Data Source:
BioGRID
(pull down)
NF2
AGAP2
Description
neurofibromin 2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleolus
Cytoplasm
Early Endosome
Cytosol
Cytoskeleton
Plasma Membrane
Adherens Junction
Membrane
Lamellipodium
Cortical Actin Cytoskeleton
Filopodium Membrane
Cleavage Furrow
Ruffle Membrane
Neuron Projection
Cell Body
Apical Part Of Cell
Perinuclear Region Of Cytoplasm
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Membrane
Extracellular Exosome
Flemming Body
Molecular Function
Actin Binding
Protein Binding
GTPase Activity
GTPase Activator Activity
Protein Binding
ATP Binding
GTP Binding
Protein Kinase Binding
Protein Kinase Activator Activity
Phosphatidylinositol 3-kinase Regulator Activity
Metal Ion Binding
Biological Process
Mesoderm Formation
Negative Regulation Of Cell-matrix Adhesion
Negative Regulation Of Protein Kinase Activity
Ectoderm Development
Negative Regulation Of Cell Population Proliferation
Schwann Cell Proliferation
Regulation Of Gliogenesis
Hippocampus Development
Negative Regulation Of Cell-cell Adhesion
Actin Cytoskeleton Organization
Negative Regulation Of Cell Migration
Regulation Of Protein Stability
Regulation Of Hippo Signaling
Odontogenesis Of Dentin-containing Tooth
Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein
Regulation Of Apoptotic Process
Negative Regulation Of MAPK Cascade
Cell-cell Junction Organization
Positive Regulation Of Cell Differentiation
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Stress Fiber Assembly
Regulation Of Cell Cycle
Lens Fiber Cell Differentiation
Regulation Of Stem Cell Proliferation
Regulation Of Protein Localization To Nucleus
Regulation Of Neural Precursor Cell Proliferation
Protein Transport
Endosomal Transport
Actin Cytoskeleton Organization
Activation Of Protein Kinase Activity
Negative Regulation Of Protein Catabolic Process
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of 1-phosphatidylinositol-3-kinase Activity
Pathways
Regulation of actin dynamics for phagocytic cup formation
RHO GTPases activate PAKs
Netrin-1 signaling
Drugs
Diseases
Malignant pleural mesothelioma
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Carotid atherosclerosis in HIV infection (
20009918
)
Heel bone mineral density (
30598549
)
Multiple sclerosis (
21833088
)
Interacting Genes
74 interacting genes:
AGAP2
AKT1
AMOT
AMOTL2
ARAF
ARNT
AURKA
BDKRB1
BECN1
BYSL
CBLC
CCNB1IP1
CCND2
CCNE1
CD44
CDK4
CDK6
CDKN2B
CDKN2C
CTNNB1
DACH1
DCAF1
EGFR
EIF3B
EMD
EPHA2
ERBB2
EZR
FGFR4
FZR1
GLIS2
GRM1
HGF
HGS
HIF1A
IGF1R
ITGB1
KAT2A
KDELR2
KDM1A
LATS1
LATS2
MAP2K3
MAP2K5
MAP3K5
MAPK14
MDM4
MED28
MET
MYBPC2
MYC
PAK1
PDGFRA
PRKCA
PXN
PYGO2
RAF1
RALGDS
RASSF1
SCHIP1
SDCBP
SGSM3
SLC9A3R1
SOX3
SOX4
SPTBN1
STK11
TARBP2
TERT
TP53
TSC1
TTYH2
TXLNB
XPO1
13 interacting genes:
AKT1
ARF1
CDC42
EPB41L1
GRIP1
HOMER1
HOMER2
NF2
PIK3R1
PLCG1
RAC1
RAC2
RHOA
Entrez ID
4771
116986
HPRD ID
06980
05687
Ensembl ID
ENSG00000186575
ENSG00000135439
Uniprot IDs
A0A024R1D9
A0A024R1F6
A0A024R1I0
A0A024R1J8
A0A024R1J9
P35240
A0A024RB55
F8VVT9
Q99490
PDB IDs
1H4R
3U8Z
4ZRI
4ZRJ
6CDS
2BMJ
2IWR
2RLO
Enriched GO Terms of Interacting Partners
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