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TARBP2 and PNKP
Data Source:
BioGRID
(two hybrid)
TARBP2
PNKP
Description
TARBP2 subunit of RISC loading complex
polynucleotide kinase 3'-phosphatase
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
RISC Complex
Nuclear Body
Perinuclear Region Of Cytoplasm
RISC-loading Complex
Nucleus
Nucleoplasm
Nucleolus
Mitochondrion
Membrane
Molecular Function
Double-stranded RNA Binding
Protein Binding
Enzyme Binding
SiRNA Binding
MiRNA Binding
Pre-mRNA Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein N-terminus Binding
Pre-miRNA Binding
Damaged DNA Binding
Double-stranded DNA Binding
Endonuclease Activity
Protein Binding
ATP Binding
Purine Nucleotide Binding
Polynucleotide 3'-phosphatase Activity
ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity
Biological Process
Negative Regulation Of Protein Kinase Activity
Spermatid Development
Single Fertilization
MiRNA Metabolic Process
Production Of SiRNA Involved In RNA Interference
Targeting Of MRNA For Destruction Involved In RNA Interference
Pre-miRNA Processing
SiRNA Loading Onto RISC Involved In RNA Interference
Production Of MiRNAs Involved In Gene Silencing By MiRNA
Multicellular Organism Growth
MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA
Skeletal Muscle Tissue Regeneration
Positive Regulation Of Viral Genome Replication
Positive Regulation Of Translation
Regulation Of Viral Transcription
Negative Regulation Of Defense Response To Virus By Host
Positive Regulation Of Muscle Cell Differentiation
Neural Precursor Cell Proliferation
Regulation Of Production Of SiRNA Involved In RNA Interference
Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Nucleotide-excision Repair, DNA Damage Removal
DNA-dependent DNA Replication
DNA Repair
Response To Oxidative Stress
Response To Radiation
Negative Regulation Of Protein ADP-ribosylation
Dephosphorylation
Positive Regulation Of Telomere Maintenance Via Telomerase
DNA Damage Response, Detection Of DNA Damage
Nucleotide Phosphorylation
Positive Regulation Of Telomerase Activity
Nucleic Acid Phosphodiester Bond Hydrolysis
Polynucleotide 3' Dephosphorylation
Positive Regulation Of Telomere Capping
Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways
MicroRNA (miRNA) biogenesis
Small interfering RNA (siRNA) biogenesis
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs
Diseases
Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age <50) (
26426971
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
27 interacting genes:
ADARB1
AGO2
APP
DICER1
EIF2AK2
HDHD2
HSPB1
IKBKG
KCNIP3
MAPK8IP2
MED21
NEDD4L
NEUROG1
NF2
NUDT18
PNKP
PRKRA
RBM14
TCEA2
TCEANC
TGIF2
TOP1
TRAF4
VAV2
ZMAT3
ZMAT4
ZNF346
49 interacting genes:
APP
CACFD1
CAMK2B
CARD10
CCDC14
CCDC43
CISD2
CNTROB
COL17A1
DVL3
FADS6
GAS8
GZMK
IKZF1
KANK2
KDM1A
KLHL12
KRTAP4-12
LMNA
MAGEA11
MCC
MEOX2
MGST2
MSANTD4
MYOZ1
OBI1
PICK1
PNMA5
POLB
PSTPIP1
RPRM
SFT2D1
SMAD5
SNX2
SP4
SUV39H1
SYNGR1
SYNGR3
SYP
TARBP2
TBC1D1
THAP1
TMEM239
TNIP1
TRIM37
XRCC1
XRCC4
ZBTB14
ZNF639
Entrez ID
6895
11284
HPRD ID
05446
09284
Ensembl ID
ENSG00000139546
ENSG00000039650
Uniprot IDs
A0A024RB49
Q15633
Q96T60
PDB IDs
2CPN
3ADL
3LLH
4WYQ
5N8L
5N8M
5ZAK
5ZAL
5ZAM
2BRF
2W3O
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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