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NF2 and LATS1
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, imaging technique, pull down)
NF2
LATS1
Description
neurofibromin 2
large tumor suppressor kinase 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleolus
Cytoplasm
Early Endosome
Cytosol
Cytoskeleton
Plasma Membrane
Adherens Junction
Membrane
Lamellipodium
Cortical Actin Cytoskeleton
Filopodium Membrane
Cleavage Furrow
Ruffle Membrane
Neuron Projection
Cell Body
Apical Part Of Cell
Perinuclear Region Of Cytoplasm
Spindle Pole
Nucleus
Microtubule Organizing Center
Cytosol
Midbody
Molecular Function
Actin Binding
Protein Binding
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Estrogen Receptor Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Mesoderm Formation
Negative Regulation Of Cell-matrix Adhesion
Negative Regulation Of Protein Kinase Activity
Ectoderm Development
Negative Regulation Of Cell Population Proliferation
Schwann Cell Proliferation
Regulation Of Gliogenesis
Hippocampus Development
Negative Regulation Of Cell-cell Adhesion
Actin Cytoskeleton Organization
Negative Regulation Of Cell Migration
Regulation Of Protein Stability
Regulation Of Hippo Signaling
Odontogenesis Of Dentin-containing Tooth
Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein
Regulation Of Apoptotic Process
Negative Regulation Of MAPK Cascade
Cell-cell Junction Organization
Positive Regulation Of Cell Differentiation
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Stress Fiber Assembly
Regulation Of Cell Cycle
Lens Fiber Cell Differentiation
Regulation Of Stem Cell Proliferation
Regulation Of Protein Localization To Nucleus
Regulation Of Neural Precursor Cell Proliferation
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Sister Chromatid Segregation
Inner Cell Mass Cell Fate Commitment
Inner Cell Mass Cellular Morphogenesis
Protein Phosphorylation
Hormone-mediated Signaling Pathway
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Peptidyl-serine Phosphorylation
Keratinocyte Differentiation
Regulation Of Actin Filament Polymerization
Positive Regulation Of Peptidyl-serine Phosphorylation
Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Cellular Protein Localization
Hippo Signaling
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Organ Growth
Cytoplasmic Sequestering Of Protein
Cell Division
Mammary Gland Epithelial Cell Differentiation
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Protein Localization To Nucleus
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
Regulation of actin dynamics for phagocytic cup formation
RHO GTPases activate PAKs
Signaling by Hippo
Drugs
Fostamatinib
Diseases
Malignant pleural mesothelioma
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Carotid atherosclerosis in HIV infection (
20009918
)
Brain morphology (MOSTest) (
32665545
)
Nicotine dependence and major depression (severity of comorbidity) (
30287806
)
Subcortical volume (MOSTest) (
32665545
)
Testicular germ cell tumor (
28604728
)
Interacting Genes
74 interacting genes:
AGAP2
AKT1
AMOT
AMOTL2
ARAF
ARNT
AURKA
BDKRB1
BECN1
BYSL
CBLC
CCNB1IP1
CCND2
CCNE1
CD44
CDK4
CDK6
CDKN2B
CDKN2C
CTNNB1
DACH1
DCAF1
EGFR
EIF3B
EMD
EPHA2
ERBB2
EZR
FGFR4
FZR1
GLIS2
GRM1
HGF
HGS
HIF1A
IGF1R
ITGB1
KAT2A
KDELR2
KDM1A
LATS1
LATS2
MAP2K3
MAP2K5
MAP3K5
MAPK14
MDM4
MED28
MET
MYBPC2
MYC
PAK1
PDGFRA
PRKCA
PXN
PYGO2
RAF1
RALGDS
RASSF1
SCHIP1
SDCBP
SGSM3
SLC9A3R1
SOX3
SOX4
SPTBN1
STK11
TARBP2
TERT
TP53
TSC1
TTYH2
TXLNB
XPO1
48 interacting genes:
ALPP
APP
ARPC3
AURKB
CAV1
CBY2
CDC26
CDK1
CEP76
EIF4EBP1
FOXL2
FSD2
GOLGA2
KRT31
LDOC1
LIMK1
LRRK2
MAGI3
MOAP1
MOB3A
MOB3B
MOB3C
MOB4
NEDD4
NF2
NUAK1
NUAK2
OSTF1
PABPN1
PPM1F
PPP1R11
PPP6R3
PTEN
RAC1
SMURF1
SMURF2
SSX2IP
STK3
STK4
TAZ
TFIP11
TRAF1
UBE2I
UBQLN2
WWOX
WWP1
WWTR1
ZYX
Entrez ID
4771
9113
HPRD ID
06980
09147
Ensembl ID
ENSG00000186575
ENSG00000131023
Uniprot IDs
A0A024R1D9
A0A024R1F6
A0A024R1I0
A0A024R1J8
A0A024R1J9
P35240
O95835
PDB IDs
1H4R
3U8Z
4ZRI
4ZRJ
6CDS
4ZRK
5B5W
5BRK
Enriched GO Terms of Interacting Partners
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