KRT16 and PUS10

Data Source:
BioGRID (two hybrid)

		KRT16	PUS10
Description		keratin 16	pseudouridine synthase 10
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Intermediate Filament Extracellular Exosome	Nucleus Cytoplasm Mitochondrion
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding	Protein Binding Pseudouridine Synthase Activity Metal Ion Binding Primary MiRNA Binding TRNA Pseudouridine Synthase Activity
	Biological Process	Morphogenesis Of An Epithelium Inflammatory Response Cytoskeleton Organization Aging Keratinocyte Differentiation Negative Regulation Of Cell Migration Keratinization Hair Cycle Innate Immune Response Intermediate Filament Cytoskeleton Organization Keratinocyte Migration Establishment Of Skin Barrier Cornification	Primary MiRNA Processing TRNA Pseudouridine Synthesis
Pathways		Keratinization Formation of the cornified envelope
Drugs		Zinc Zinc acetate
Diseases		Non-epidermolytic palmoplantar keratoderma (NEPPK) Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
GWAS			Atopic dermatitis ( 26482879) Celiac disease ( 22057235 25920553 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 22412388) Crohn's disease and celiac disease ( 21298027) Erectile dysfunction ( 30583798) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 31604244) Ulcerative colitis ( 28067908 20228799 21297633)
Interacting Genes		56 interacting genes: AMOT ARFIP2 C1orf109 C1orf216 CARD9 CCDC146 CCDC17 CCHCR1 CCNC CDK18 CYTH4 EPM2AIP1 GAS8 GNG10 HGS KIFC3 KLC4 KRT1 KRT2 KRT3 KRT4 KRT5 KRT6A KRT6C KRT71 KRT72 KRT73 KRT74 KRT76 KRT78 KRT79 KRT8 KRT80 KRT81 KRT83 KRT85 KRT86 LMO1 LNX1 MBD3 PKN1 POLL PPP1R18 PRKAA2 PRPH PUS10 SEMA4C SGF29 SMARCD1 SMARCE1 SNAPIN TCHP TSG101 TTC23 TXLNB USHBP1	5 interacting genes: ABITRAM KRT14 KRT16 NECAB2 USP25
Entrez ID		3868	150962
HPRD ID		01018	08126
Ensembl ID		ENSG00000186832	ENSG00000162927
Uniprot IDs		P08779	A8K6R4 Q3MIT2
PDB IDs			2V9K
Enriched GO Terms of Interacting Partners?
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