PFDN6 and THAP11

Data Source:
BioGRID (two hybrid)

		PFDN6	THAP11
Description		prefoldin subunit 6	THAP domain containing 11
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GO Annotations	Cellular Component	Cytoplasm Prefoldin Complex	Chromatin Nucleoplasm Cytosol
	Molecular Function	Amyloid-beta Binding Protein Binding Unfolded Protein Binding Chaperone Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding
	Biological Process	Protein Folding Chaperone-mediated Protein Complex Assembly Negative Regulation Of Amyloid Fibril Formation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026)	Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252) Schizophrenia ( 25056061 29483656)
Interacting Genes		12 interacting genes: AIMP2 B4GALT2 CCHCR1 CEBPG FBXO2 KANK2 KIFC3 MAGEB4 MBD3 PFDN5 RPRD1B THAP11	20 interacting genes: BBLN CASP3 CTBP1 ECT2 HCFC1 HDAC1 HDAC3 HEMGN L3MBTL2 LRRC45 MCPH1 NUTF2 PFDN6 PSMC5 SIN3A SLX1B SRSF11 THAP7 TPX2 VPS52
Entrez ID		10471	57215
HPRD ID		16135	11629
Ensembl ID		ENSG00000204220	ENSG00000168286
Uniprot IDs		O15212 Q5STK2	Q96EK4
PDB IDs		6NR8 6NR9 6NRB 6NRC 6NRD	2LAU 5AJS
Enriched GO Terms of Interacting Partners?
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