PFDN6 and FBXO2

Data Source:
BioGRID (two hybrid)

		PFDN6	FBXO2
Description		prefoldin subunit 6	F-box protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Prefoldin Complex	Cytoplasm Endoplasmic Reticulum Cytosol SCF Ubiquitin Ligase Complex Organelle Membrane Dendritic Spine
	Molecular Function	Amyloid-beta Binding Protein Binding Unfolded Protein Binding Chaperone Binding	Amyloid-beta Binding Ubiquitin-protein Transferase Activity Protein Binding Carbohydrate Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Folding Chaperone-mediated Protein Complex Assembly Negative Regulation Of Amyloid Fibril Formation	Protein Polyubiquitination Cellular Protein Modification Process Proteolysis Glycoprotein Catabolic Process Negative Regulation Of Cell Population Proliferation Protein Ubiquitination Ubiquitin-dependent ERAD Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Post-translational Protein Modification
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		12 interacting genes: AIMP2 B4GALT2 CCHCR1 CEBPG FBXO2 KANK2 KIFC3 MAGEB4 MBD3 PFDN5 RPRD1B THAP11	16 interacting genes: AHSG BACE1 BRAP ECPAS IGH ITGB1 PAX4 PFDN6 SKP1 STUB1 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L3 VSTM1
Entrez ID		10471	26232
HPRD ID		16135	06171
Ensembl ID		ENSG00000204220	ENSG00000116661
Uniprot IDs		O15212 Q5STK2	Q9UK22
PDB IDs		6NR8 6NR9 6NRB 6NRC 6NRD
Enriched GO Terms of Interacting Partners?
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