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UBQLN1 and FBXO25
Data Source:
BioGRID
(enzymatic study)
UBQLN1
FBXO25
Description
ubiquilin 1
F-box protein 25
Image
No pdb structure
GO Annotations
Cellular Component
Proteasome Complex
Nucleoplasm
Cytoplasm
Autophagosome
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Aggresome
Cytoplasmic Vesicle
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Ubiquitin Ligase Complex
Nucleus
Nucleolus
SCF Ubiquitin Ligase Complex
Molecular Function
Protein Binding
Kinase Binding
Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
Actin Binding
Ubiquitin-protein Transferase Activity
Biological Process
Autophagosome Assembly
Ubiquitin-dependent Protein Catabolic Process
Macroautophagy
Regulation Of Macroautophagy
Ubiquitin-dependent ERAD Pathway
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Response To Endoplasmic Reticulum Stress
Aggrephagy
Cellular Response To Hypoxia
Autophagosome Maturation
Negative Regulation Of Store-operated Calcium Channel Activity
Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Pathways
Cargo recognition for clathrin-mediated endocytosis
Drugs
Diseases
GWAS
Metabolite levels (
23823483
)
Refractive error (
32231278
)
Neonatal cytokine/chemokine levels (fetal genetic effect) (
30134952
)
Interacting Genes
233 interacting genes:
ABCC2
ACOT7
ADRM1
AGPAT5
AGR2
AGR3
ANOS1
APOC2
APOC4
APP
ASCL1
ATXN3
BAG6
BPIFA1
C1QA
C1QTNF2
C1QTNF4
CALU
CCL3
CCL7
CD47
CD99
CD99L2
CDIP1
CDSN
CHGB
CHRNA3
CHRNA4
CHRNB4
CLCN2
COL10A1
COL1A2
COL9A2
COLGALT2
COMTD1
COPS4
CSN3
CSTF2
CSTF2T
CTAG1A
CTAG1B
CTAG2
CYB5R1
DAZAP2
DEFA6
DEFB115
DESI1
DEXI
DMKN
DNAJB2
DOLK
ECM1
EFEMP2
EP300
EPS15
ERP27
ERP29
ETNK1
F8
FAM163B
FAM189A2
FAM86B3P
FAS
FBXO25
FCGR2A
FGF7
FKBP2
FN1
FOLR3
FZD7
GABRA1
GABRA2
GABRA3
GABRA6
GABRB1
GABRB2
GABRB3
GABRD
GAL
GHRL
GIT2
GKAP1
GPR162
GPX3
GRM2
GUCA2A
GUCA2B
GYPB
HERC3
HES1
HGS
HK2
HSD17B12
HSPA13
IER3IP1
IGFBP6
IGL
IGLC1
IGLV2-14
IL6ST
IRF1-AS1
IST1
ITPRIPL1
JPH4
JSRP1
KLHL42
LAIR2
LAMB1
LCN2
LHX4
LITAF
LNPEP
MANBAL
MAP3K1
MCM7
MDK
MESD
MICOS10-NBL1
MIEF1
MIEF2
MLLT6
MTNR1A
MTOR
MYDGF
NAXD
NBL1
NDE1
NDOR1
NEDD8
NGLY1
NLGN3
NME3
NPPA
NPY
NT5C3A
NUP58
NXF1
OST4
P4HB
PARVA
PBXIP1
PCDH18
PCDHA4
PIAS2
PIK3IP1
PLAAT1
PLAAT2
PLAAT3
PNMA1
PPIB
PPIC
PRAP1
PRB1
PRPF40A
PRR4
PSEN1
PSEN2
PSMD4
PSMD6
PSORS1C2
PTN
RAI2
RARA
RASSF5
RIC8A
RNF144B
RNF208
RNF4
RPN1
RPS27A
RSRC2
RTL8A
RTL8B
RTL8C
SCG2
SCG5
SCMH1
SERPINE1
SERPINI2
SEZ6L
SIL1
SLC16A3
SLC29A2
SLPI
SMAD9
SMIM19
SMIM2
SMR3B
SMURF1
SOD3
SPAG8
SPARC
SRGN
STAM2
STMN3
SYNJ2BP
TARDBP
TFF1
TICAM1
TLR4
TMCO6
TMEM258
TMEM31
TMEM37
TMEM67
TMUB2
TNFRSF1A
TNFRSF1B
TREX1
TRIM23
TRIM32
TXNDC12
UBA52
UBB
UBC
UBE2I
UBE2V1
UBE3A
UBQLN2
UBQLN4
UBXN1
UBXN4
UBXN7
VWC2
WBP2
WFDC12
XPO4
ZBTB8B
ZFAND2B
ZG16
ZG16B
ZMYM5
ZNF343
82 interacting genes:
ANKRD13A
APLF
AXL
BMX
BRME1
C7orf50
CDK5RAP2
CDK9
CENPB
CUL1
CXXC4
DCX
DDX42
DEPTOR
DNAJB2
DNAJC8
DYRK3
DYRK4
EGFR
EID3
EIF4E2
ELK1
EPN1
FKBP3
G3BP1
GRK2
GTF2B
GTF2IRD2
HIP1
HMCES
HP1BP3
IL21
ILRUN
ING3
IRS1
JHY
KDR
KRT8
LMCD1
LUC7L
MAT2B
NKX2-5
NSRP1
NUAK1
ODF2
ORC4
PADI4
PAK4
PCK1
PDGFRA
PIP4K2C
PPID
PPP1R8
PRKCA
PRKG2
PRR15
PRRG1
PSMD4
RABEP2
RBM8A
RHBDD1
RIOK3
RPAP3
RPS10
RPS6KB2
SAMHD1
SERBP1
SKP1
STAC
SYTL2
TBX5
TCEAL2
TCEANC
TCP10L
TMA7
TNIP2
TRUB1
TWF1
UBE2D3
UBQLN1
UBQLN2
WDSUB1
Entrez ID
29979
26260
HPRD ID
05440
16439
Ensembl ID
ENSG00000135018
ENSG00000147364
Uniprot IDs
A0A024R258
Q9UMX0
A0A024QZ88
Q8TCJ0
PDB IDs
2JY5
2JY6
2KLC
Enriched GO Terms of Interacting Partners
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