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UBQLN1 and FN1
Data Source:
BioGRID
(two hybrid)
UBQLN1
FN1
Description
ubiquilin 1
fibronectin 1
Image
GO Annotations
Cellular Component
Proteasome Complex
Nucleoplasm
Cytoplasm
Autophagosome
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Aggresome
Cytoplasmic Vesicle
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Extracellular Region
Fibrinogen Complex
Basement Membrane
Extracellular Space
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum-Golgi Intermediate Compartment
Apical Plasma Membrane
Extracellular Matrix
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Blood Microparticle
Molecular Function
Protein Binding
Kinase Binding
Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
Protease Binding
Signaling Receptor Binding
Integrin Binding
Extracellular Matrix Structural Constituent
Protein Binding
Collagen Binding
Protein C-terminus Binding
Heparin Binding
Peptidase Activator Activity
Enzyme Binding
Identical Protein Binding
Proteoglycan Binding
Chaperone Binding
Disordered Domain Specific Binding
Biological Process
Autophagosome Assembly
Ubiquitin-dependent Protein Catabolic Process
Macroautophagy
Regulation Of Macroautophagy
Ubiquitin-dependent ERAD Pathway
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Response To Endoplasmic Reticulum Stress
Aggrephagy
Cellular Response To Hypoxia
Autophagosome Maturation
Negative Regulation Of Store-operated Calcium Channel Activity
Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process
Angiogenesis
Regulation Of Protein Phosphorylation
Platelet Degranulation
Acute-phase Response
Cell-substrate Junction Assembly
Cell Adhesion
Cell-matrix Adhesion
Calcium-independent Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Nervous System Development
Heart Development
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Response To Wounding
Positive Regulation Of Gene Expression
Positive Regulation Of Peptidase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptide Cross-linking
Cytokine-mediated Signaling Pathway
Extracellular Matrix Organization
Integrin Activation
Substrate Adhesion-dependent Cell Spreading
Endodermal Cell Differentiation
Post-translational Protein Modification
Cellular Protein Metabolic Process
Positive Regulation Of Axon Extension
Positive Regulation Of Fibroblast Proliferation
Leukocyte Migration
Biological Process Involved In Interaction With Symbiont
Regulation Of ERK1 And ERK2 Cascade
Platelet Aggregation
Negative Regulation Of Transforming Growth Factor Beta Production
Blood Coagulation, Fibrin Clot Formation
Neural Crest Cell Migration Involved In Autonomic Nervous System Development
Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate
Pathways
Cargo recognition for clathrin-mediated endocytosis
Platelet degranulation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Extracellular matrix organization
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MAP2K and MAPK activation
Interleukin-4 and Interleukin-13 signaling
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
MET activates PTK2 signaling
Post-translational protein phosphorylation
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Drugs
Zinc
Lanoteplase
Ocriplasmin
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
GWAS
Metabolite levels (
23823483
)
Refractive error (
32231278
)
Apolipoprotein B levels (
32203549
)
Blood protein levels (
28240269
)
Cholesterol, total (
26780889
)
Coronary artery disease (
32469254
29212778
28714974
33020668
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
Diastolic blood pressure (
30578418
)
LDL cholesterol (
24097068
)
LDL cholesterol levels (
32203549
28334899
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Negative urgency (
30718321
)
Pulse pressure (
28135244
27841878
30578418
)
Systolic blood pressure (
27841878
30578418
)
Total cholesterol levels (
28334899
)
White blood cell count (
32888494
)
Interacting Genes
233 interacting genes:
ABCC2
ACOT7
ADRM1
AGPAT5
AGR2
AGR3
ANOS1
APOC2
APOC4
APP
ASCL1
ATXN3
BAG6
BPIFA1
C1QA
C1QTNF2
C1QTNF4
CALU
CCL3
CCL7
CD47
CD99
CD99L2
CDIP1
CDSN
CHGB
CHRNA3
CHRNA4
CHRNB4
CLCN2
COL10A1
COL1A2
COL9A2
COLGALT2
COMTD1
COPS4
CSN3
CSTF2
CSTF2T
CTAG1A
CTAG1B
CTAG2
CYB5R1
DAZAP2
DEFA6
DEFB115
DESI1
DEXI
DMKN
DNAJB2
DOLK
ECM1
EFEMP2
EP300
EPS15
ERP27
ERP29
ETNK1
F8
FAM163B
FAM189A2
FAM86B3P
FAS
FBXO25
FCGR2A
FGF7
FKBP2
FN1
FOLR3
FZD7
GABRA1
GABRA2
GABRA3
GABRA6
GABRB1
GABRB2
GABRB3
GABRD
GAL
GHRL
GIT2
GKAP1
GPR162
GPX3
GRM2
GUCA2A
GUCA2B
GYPB
HERC3
HES1
HGS
HK2
HSD17B12
HSPA13
IER3IP1
IGFBP6
IGL
IGLC1
IGLV2-14
IL6ST
IRF1-AS1
IST1
ITPRIPL1
JPH4
JSRP1
KLHL42
LAIR2
LAMB1
LCN2
LHX4
LITAF
LNPEP
MANBAL
MAP3K1
MCM7
MDK
MESD
MICOS10-NBL1
MIEF1
MIEF2
MLLT6
MTNR1A
MTOR
MYDGF
NAXD
NBL1
NDE1
NDOR1
NEDD8
NGLY1
NLGN3
NME3
NPPA
NPY
NT5C3A
NUP58
NXF1
OST4
P4HB
PARVA
PBXIP1
PCDH18
PCDHA4
PIAS2
PIK3IP1
PLAAT1
PLAAT2
PLAAT3
PNMA1
PPIB
PPIC
PRAP1
PRB1
PRPF40A
PRR4
PSEN1
PSEN2
PSMD4
PSMD6
PSORS1C2
PTN
RAI2
RARA
RASSF5
RIC8A
RNF144B
RNF208
RNF4
RPN1
RPS27A
RSRC2
RTL8A
RTL8B
RTL8C
SCG2
SCG5
SCMH1
SERPINE1
SERPINI2
SEZ6L
SIL1
SLC16A3
SLC29A2
SLPI
SMAD9
SMIM19
SMIM2
SMR3B
SMURF1
SOD3
SPAG8
SPARC
SRGN
STAM2
STMN3
SYNJ2BP
TARDBP
TFF1
TICAM1
TLR4
TMCO6
TMEM258
TMEM31
TMEM37
TMEM67
TMUB2
TNFRSF1A
TNFRSF1B
TREX1
TRIM23
TRIM32
TXNDC12
UBA52
UBB
UBC
UBE2I
UBE2V1
UBE3A
UBQLN2
UBQLN4
UBXN1
UBXN4
UBXN7
VWC2
WBP2
WFDC12
XPO4
ZBTB8B
ZFAND2B
ZG16
ZG16B
ZMYM5
ZNF343
105 interacting genes:
ADAMTS4
AMBP
ANOS1
APCS
ATXN10
ATXN7
C1QA
CCN3
CD44
CDKN2A
COL13A1
COL1A1
COL1A2
COL2A1
COL4A1
COL4A2
COL4A3
COL4A4
COL4A5
COL4A6
COL6A2
COL7A1
COMP
CRP
CTSD
CXCL12
DCN
DUSP10
EGFR
F13A1
FAM86B3P
FASLG
FBLN1
FBLN2
FST
FSTL3
GALNT6
GRB2
GSN
HGF
HRG
HSPG2
IGFBP3
IGFBP5
ITGA2B
ITGA3
ITGA4
ITGA5
ITGA8
ITGB1
ITGB3
ITGB6
ITGB7
KLK3
KPNA2
LACRT
LGALS3BP
LPA
LRG1
LTBP1
MAG
MATN2
MEP1A
MEP1B
MIA
MMP9
MTDH
MTNR1A
MYOC
NR0B2
NT5E
PELI2
PKD1
PLAT
PLG
PRELP
PRPF40A
RARA
RBL1
REG3A
RPS6KA5
SCGB1A1
SDC2
SGCA
SH3GLB1
SKIL
SMAD4
SMAD9
SPARC
STAT5A
TAB1
TAB2
TAC1
TGFBI
TGM2
THBS1
TIMD4
TMPRSS6
TNC
TNFRSF11B
TSHR
TTN
UBQLN1
VEGFA
VHL
Entrez ID
29979
2335
HPRD ID
05440
00626
Ensembl ID
ENSG00000135018
ENSG00000115414
Uniprot IDs
A0A024R258
Q9UMX0
B7ZLE5
P02751
Q6MZF4
Q6MZM7
Q6N084
Q9UQS6
PDB IDs
2JY5
2JY6
2KLC
1E88
1E8B
1FBR
1FNA
1FNF
1FNH
1J8K
1O9A
1OWW
1Q38
1QGB
1QO6
1TTF
1TTG
2CG6
2CG7
2CK2
2CKU
2EC3
2FN2
2FNB
2GEE
2H41
2H45
2HA1
2MNU
2N1K
2OCF
2RKY
2RKZ
2RL0
3CAL
3EJH
3GXE
3M7P
3MQL
3R8Q
3T1W
3ZRZ
4GH7
4JE4
4JEG
4LXO
4MMX
4MMY
4MMZ
4PZ5
5DC0
5DC4
5DC9
5DFT
5J6Z
5J7C
5M0A
5N47
5N48
6HNF
6MFA
6MSV
6NAJ
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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