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UBQLN1 and BAG6
Data Source:
BioGRID
(two hybrid)
UBQLN1
BAG6
Description
ubiquilin 1
BAG cochaperone 6
Image
GO Annotations
Cellular Component
Proteasome Complex
Nucleoplasm
Cytoplasm
Autophagosome
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Aggresome
Cytoplasmic Vesicle
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Membrane
Intracellular Membrane-bounded Organelle
Extracellular Exosome
BAT3 Complex
Molecular Function
Protein Binding
Kinase Binding
Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
Signaling Receptor Binding
Protein Binding
Polyubiquitin Modification-dependent Protein Binding
Ubiquitin Protein Ligase Binding
Ribosome Binding
Misfolded Protein Binding
Proteasome Binding
Ubiquitin-specific Protease Binding
Biological Process
Autophagosome Assembly
Ubiquitin-dependent Protein Catabolic Process
Macroautophagy
Regulation Of Macroautophagy
Ubiquitin-dependent ERAD Pathway
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Response To Endoplasmic Reticulum Stress
Aggrephagy
Cellular Response To Hypoxia
Autophagosome Maturation
Negative Regulation Of Store-operated Calcium Channel Activity
Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process
Kidney Development
Immune Response-activating Cell Surface Receptor Signaling Pathway
Chromatin Organization
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Synaptonemal Complex Assembly
Spermatogenesis
Brain Development
Proteasomal Protein Catabolic Process
Internal Peptidyl-lysine Acetylation
Natural Killer Cell Activation
Cell Differentiation
Lung Development
Ubiquitin-dependent ERAD Pathway
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Proteolysis
Regulation Of Embryonic Development
Protein Stabilization
Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
ER-associated Misfolded Protein Catabolic Process
Tail-anchored Membrane Protein Insertion Into ER Membrane
Positive Regulation Of ERAD Pathway
Maintenance Of Unfolded Protein Involved In ERAD Pathway
Protein Localization To Cytosolic Proteasome Complex Involved In ERAD Pathway
Pathways
Cargo recognition for clathrin-mediated endocytosis
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS
Metabolite levels (
23823483
)
Refractive error (
32231278
)
Asthma (
31619474
)
Asthma (childhood onset) (
31619474
)
Asthma and major depressive disorder (
31619474
)
Autism spectrum disorder or schizophrenia (
28540026
)
Blood protein levels (
28240269
)
Height (
28552196
)
Inflammatory bowel disease (
28067908
)
Malaria (
31844061
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (HMG CoA reductase inhibitors) (
31015401
)
Schizophrenia (
23894747
)
Small cell lung carcinoma (
28604730
)
Smoking status (ever vs never smokers) (
30643258
)
Ulcerative colitis (
28067908
)
Interacting Genes
233 interacting genes:
ABCC2
ACOT7
ADRM1
AGPAT5
AGR2
AGR3
ANOS1
APOC2
APOC4
APP
ASCL1
ATXN3
BAG6
BPIFA1
C1QA
C1QTNF2
C1QTNF4
CALU
CCL3
CCL7
CD47
CD99
CD99L2
CDIP1
CDSN
CHGB
CHRNA3
CHRNA4
CHRNB4
CLCN2
COL10A1
COL1A2
COL9A2
COLGALT2
COMTD1
COPS4
CSN3
CSTF2
CSTF2T
CTAG1A
CTAG1B
CTAG2
CYB5R1
DAZAP2
DEFA6
DEFB115
DESI1
DEXI
DMKN
DNAJB2
DOLK
ECM1
EFEMP2
EP300
EPS15
ERP27
ERP29
ETNK1
F8
FAM163B
FAM189A2
FAM86B3P
FAS
FBXO25
FCGR2A
FGF7
FKBP2
FN1
FOLR3
FZD7
GABRA1
GABRA2
GABRA3
GABRA6
GABRB1
GABRB2
GABRB3
GABRD
GAL
GHRL
GIT2
GKAP1
GPR162
GPX3
GRM2
GUCA2A
GUCA2B
GYPB
HERC3
HES1
HGS
HK2
HSD17B12
HSPA13
IER3IP1
IGFBP6
IGL
IGLC1
IGLV2-14
IL6ST
IRF1-AS1
IST1
ITPRIPL1
JPH4
JSRP1
KLHL42
LAIR2
LAMB1
LCN2
LHX4
LITAF
LNPEP
MANBAL
MAP3K1
MCM7
MDK
MESD
MICOS10-NBL1
MIEF1
MIEF2
MLLT6
MTNR1A
MTOR
MYDGF
NAXD
NBL1
NDE1
NDOR1
NEDD8
NGLY1
NLGN3
NME3
NPPA
NPY
NT5C3A
NUP58
NXF1
OST4
P4HB
PARVA
PBXIP1
PCDH18
PCDHA4
PIAS2
PIK3IP1
PLAAT1
PLAAT2
PLAAT3
PNMA1
PPIB
PPIC
PRAP1
PRB1
PRPF40A
PRR4
PSEN1
PSEN2
PSMD4
PSMD6
PSORS1C2
PTN
RAI2
RARA
RASSF5
RIC8A
RNF144B
RNF208
RNF4
RPN1
RPS27A
RSRC2
RTL8A
RTL8B
RTL8C
SCG2
SCG5
SCMH1
SERPINE1
SERPINI2
SEZ6L
SIL1
SLC16A3
SLC29A2
SLPI
SMAD9
SMIM19
SMIM2
SMR3B
SMURF1
SOD3
SPAG8
SPARC
SRGN
STAM2
STMN3
SYNJ2BP
TARDBP
TFF1
TICAM1
TLR4
TMCO6
TMEM258
TMEM31
TMEM37
TMEM67
TMUB2
TNFRSF1A
TNFRSF1B
TREX1
TRIM23
TRIM32
TXNDC12
UBA52
UBB
UBC
UBE2I
UBE2V1
UBE3A
UBQLN2
UBQLN4
UBXN1
UBXN4
UBXN7
VWC2
WBP2
WFDC12
XPO4
ZBTB8B
ZFAND2B
ZG16
ZG16B
ZMYM5
ZNF343
118 interacting genes:
ACVR1B
AMFR
AMTN
ANTKMT
ANXA7
APBB1IP
ARPC3
ATN1
ATXN2
B2M
C1QA
CD93
CDK16
CDK4
CDK5
CDKN1A
CDSN
CHN2
CILK1
CLU
CSNK2B
CSTF2
CTAG1A
CTAG1B
CTCFL
CTSB
CTSE
CTSL
CXCL8
CYSRT1
DMKN
DNAJB11
DPT
EDN1
EFEMP1
EFEMP2
ELP1
EP300
FAM9B
FAS
FKBP2
FZD4
GADD45A
GET4
GLRA2
GOLGA6L9
GSK3B
HSPA13
HSPA8
IGF2
IGFBP5
IMMT
IQCG
KLHL12
KPNA2
LBP
MAPK6
MEST
MTNR1A
MYDGF
NBL1
NCR3
NDUFA6
NDUFB11
NOMO1
NPY
NR1H2
PELP1
PIN1
PLA2G2A
PLK1
PLPP2
PLPPR3
POLR2J
PRKAR1B
PRMT2
PRNP
PRPF40A
PTH
PTN
PTPN12
RAB8A
RAC1
RCC1
RCN2
REG1B
RNF126
S100A4
SDC2
SEC61A1
SEC61B
SERPING1
SERPINH1
SERPINI2
SETDB1
SGTA
SMN1
SPP1
SRGN
STX5
TAC1
TDGF1
TENT5A
TFCP2
TK1
TOMM20
TP53
TP63
TTR
UBL4B
UBL7
UBQLN1
UBQLN2
UBQLN4
USP13
VAMP2
XRN1
ZFYVE9
Entrez ID
29979
7917
HPRD ID
05440
00808
Ensembl ID
ENSG00000135018
ENSG00000204463
Uniprot IDs
A0A024R258
Q9UMX0
A0A1U9X7A6
P46379
PDB IDs
2JY5
2JY6
2KLC
1WX9
2N9P
4DWF
4EEW
4WWR
4X86
6AU8
Enriched GO Terms of Interacting Partners
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