FBXO25 and PPP1R8

Data Source:
BioGRID (enzymatic study)

		FBXO25	PPP1R8
Description		F-box protein 25	protein phosphatase 1 regulatory subunit 8
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Nuclear Speck
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity	DNA Binding RNA Binding MRNA Binding Endonuclease Activity Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Ribonuclease E Activity
	Biological Process	Protein Ubiquitination	MRNA Processing RNA Catabolic Process Cell Population Proliferation RNA Splicing Negative Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Protein Dephosphorylation RNA Phosphodiester Bond Hydrolysis
Pathways
Drugs
Diseases
GWAS		Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		82 interacting genes: ANKRD13A APLF AXL BMX BRME1 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1	27 interacting genes: APP APPBP2 CDC5L CREBBP CRMP1 CSNK2A1 CSNK2A2 CTNNBL1 EED ERG28 FBXO25 GBP2 HDAC2 HMGA1 LRRK2 LYN MELK PPIL1 PPP1CA PPP1CC PRKACA RBM48 RTN4IP1 SETDB1 SF3B1 STC2 WDR77
Entrez ID		26260	5511
HPRD ID		16439	04028
Ensembl ID		ENSG00000147364	ENSG00000117751
Uniprot IDs		A0A024QZ88 Q8TCJ0	Q12972 Q6ICT4
PDB IDs			3V4Y
Enriched GO Terms of Interacting Partners?
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