FBXO25 and PRKG2

Data Source:
BioGRID (enzymatic study)

		FBXO25	PRKG2
Description		F-box protein 25	protein kinase cGMP-dependent 2
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex	Cytosol Apical Plasma Membrane Nuclear Membrane
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity	Protein Kinase Activity CGMP-dependent Protein Kinase Activity ATP Binding CGMP Binding Identical Protein Binding
	Biological Process	Protein Ubiquitination	Protein Phosphorylation Signal Transduction Peptidyl-serine Autophosphorylation Protein Localization To Plasma Membrane Negative Regulation Of Chloride Transport
Pathways			Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Ca2+ pathway cGMP effects cGMP effects RAS processing
Drugs			Fostamatinib
Diseases
GWAS		Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)	Blood pressure (smoking interaction) ( 25189868) Body size at age 10 ( 32376654) Height ( 28552196 25282103 19343178 23563607 31562340 18391951) Hip circumference adjusted for BMI ( 25673412) HIV-1 susceptibility ( 22174851) Pubertal anthropometrics ( 23449627) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		82 interacting genes: ANKRD13A APLF AXL BMX BRME1 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1	7 interacting genes: FBXO25 LASP1 MYLK NEDD4 PLCB3 PTS WDR77
Entrez ID		26260	5593
HPRD ID		16439	09034
Ensembl ID		ENSG00000147364	ENSG00000138669
Uniprot IDs		A0A024QZ88 Q8TCJ0	A0A140VJM3 B4DLF9 B7ZA25 Q13237
PDB IDs			5BV6 5C6C 5C8W 5JIX 5JIZ 6BQ8
Enriched GO Terms of Interacting Partners?
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