UBQLN1 and UBXN1

Data Source:
BioGRID (two hybrid, biochemical)

		UBQLN1	UBXN1
Description		ubiquilin 1	UBX domain protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleoplasm Cytoplasm Autophagosome Endoplasmic Reticulum Cytosol Plasma Membrane Aggresome Cytoplasmic Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Dendrite VCP-NPL4-UFD1 AAA ATPase Complex Neuronal Cell Body
	Molecular Function	Protein Binding Kinase Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding	Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding ATPase Binding K6-linked Polyubiquitin Modification-dependent Protein Binding Proteasome Regulatory Particle Binding
	Biological Process	Autophagosome Assembly Ubiquitin-dependent Protein Catabolic Process Macroautophagy Regulation Of Macroautophagy Ubiquitin-dependent ERAD Pathway Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Response To Endoplasmic Reticulum Stress Aggrephagy Cellular Response To Hypoxia Autophagosome Maturation Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process	Protein Folding Viral Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of ERAD Pathway Negative Regulation Of Ubiquitin-specific Protease Activity
Pathways		Cargo recognition for clathrin-mediated endocytosis	N-glycan trimming in the ER and Calnexin/Calreticulin cycle Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Refractive error ( 32231278)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		233 interacting genes: ABCC2 ACOT7 ADRM1 AGPAT5 AGR2 AGR3 ANOS1 APOC2 APOC4 APP ASCL1 ATXN3 BAG6 BPIFA1 C1QA C1QTNF2 C1QTNF4 CALU CCL3 CCL7 CD47 CD99 CD99L2 CDIP1 CDSN CHGB CHRNA3 CHRNA4 CHRNB4 CLCN2 COL10A1 COL1A2 COL9A2 COLGALT2 COMTD1 COPS4 CSN3 CSTF2 CSTF2T CTAG1A CTAG1B CTAG2 CYB5R1 DAZAP2 DEFA6 DEFB115 DESI1 DEXI DMKN DNAJB2 DOLK ECM1 EFEMP2 EP300 EPS15 ERP27 ERP29 ETNK1 F8 FAM163B FAM189A2 FAM86B3P FAS FBXO25 FCGR2A FGF7 FKBP2 FN1 FOLR3 FZD7 GABRA1 GABRA2 GABRA3 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GAL GHRL GIT2 GKAP1 GPR162 GPX3 GRM2 GUCA2A GUCA2B GYPB HERC3 HES1 HGS HK2 HSD17B12 HSPA13 IER3IP1 IGFBP6 IGL IGLC1 IGLV2-14 IL6ST IRF1-AS1 IST1 ITPRIPL1 JPH4 JSRP1 KLHL42 LAIR2 LAMB1 LCN2 LHX4 LITAF LNPEP MANBAL MAP3K1 MCM7 MDK MESD MICOS10-NBL1 MIEF1 MIEF2 MLLT6 MTNR1A MTOR MYDGF NAXD NBL1 NDE1 NDOR1 NEDD8 NGLY1 NLGN3 NME3 NPPA NPY NT5C3A NUP58 NXF1 OST4 P4HB PARVA PBXIP1 PCDH18 PCDHA4 PIAS2 PIK3IP1 PLAAT1 PLAAT2 PLAAT3 PNMA1 PPIB PPIC PRAP1 PRB1 PRPF40A PRR4 PSEN1 PSEN2 PSMD4 PSMD6 PSORS1C2 PTN RAI2 RARA RASSF5 RIC8A RNF144B RNF208 RNF4 RPN1 RPS27A RSRC2 RTL8A RTL8B RTL8C SCG2 SCG5 SCMH1 SERPINE1 SERPINI2 SEZ6L SIL1 SLC16A3 SLC29A2 SLPI SMAD9 SMIM19 SMIM2 SMR3B SMURF1 SOD3 SPAG8 SPARC SRGN STAM2 STMN3 SYNJ2BP TARDBP TFF1 TICAM1 TLR4 TMCO6 TMEM258 TMEM31 TMEM37 TMEM67 TMUB2 TNFRSF1A TNFRSF1B TREX1 TRIM23 TRIM32 TXNDC12 UBA52 UBB UBC UBE2I UBE2V1 UBE3A UBQLN2 UBQLN4 UBXN1 UBXN4 UBXN7 VWC2 WBP2 WFDC12 XPO4 ZBTB8B ZFAND2B ZG16 ZG16B ZMYM5 ZNF343	19 interacting genes: ACOT7 ACVR1 BARD1 BMPR1B BRCA1 FAM189A2 HOMER2 PLA2G4A PLAA POLR3C RAD23A SMAD1 SMURF1 TGFBR1 TRIM39 UBC UBE2I UBQLN1 UBQLN2
Entrez ID		29979	51035
HPRD ID		05440	11266
Ensembl ID		ENSG00000135018	ENSG00000162191
Uniprot IDs		A0A024R258 Q9UMX0	A0A024R539 A0A024R598 A0A087WTZ5 Q04323
PDB IDs		2JY5 2JY6 2KLC
Enriched GO Terms of Interacting Partners?
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