FBXO25 and APLF

Data Source:
BioGRID (enzymatic study)

		FBXO25	APLF
Description		F-box protein 25	aprataxin and PNKP like factor
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytosol Site Of Double-strand Break
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity	Nucleotide Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Endodeoxyribonuclease Activity Protein Binding 3'-5' Exonuclease Activity Metal Ion Binding
	Biological Process	Protein Ubiquitination	Single Strand Break Repair Double-strand Break Repair Cellular Response To DNA Damage Stimulus Positive Regulation Of DNA Ligation Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways
Drugs
Diseases
GWAS		Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)	Restless legs syndrome ( 29029846) Urate levels in lean individuals ( 25811787)
Interacting Genes		82 interacting genes: ANKRD13A APLF AXL BMX BRME1 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1	7 interacting genes: APP FBXO25 GMCL1 IRX5 LIG4 XRCC1 XRCC4
Entrez ID		26260	200558
HPRD ID		16439	09848
Ensembl ID		ENSG00000147364	ENSG00000169621
Uniprot IDs		A0A024QZ88 Q8TCJ0	Q8IW19
PDB IDs			2KQB 2KQC 2KQD 2KQE 2KUO 5E50 5W7W 5W7X 5W7Y 6ERF 6TYT 6TYW 6TYZ
Enriched GO Terms of Interacting Partners?
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