UBQLN1 and MTOR

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		UBQLN1	MTOR
Description		ubiquilin 1	mechanistic target of rapamycin kinase
Image
GO Annotations	Cellular Component	Proteasome Complex Nucleoplasm Cytoplasm Autophagosome Endoplasmic Reticulum Cytosol Plasma Membrane Aggresome Cytoplasmic Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm	Golgi Membrane Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Lysosome Lysosomal Membrane Endoplasmic Reticulum Membrane Cytosol Endomembrane System Membrane PML Body Dendrite TORC1 Complex TORC2 Complex Neuronal Cell Body Phagocytic Vesicle Glutamatergic Synapse Postsynaptic Cytosol
	Molecular Function	Protein Binding Kinase Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding	RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding TFIIIC-class Transcription Factor Complex Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Protein Kinase Binding Protein Domain Specific Binding Identical Protein Binding Ribosome Binding Translation Regulator Activity Phosphoprotein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Autophagosome Assembly Ubiquitin-dependent Protein Catabolic Process Macroautophagy Regulation Of Macroautophagy Ubiquitin-dependent ERAD Pathway Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Response To Endoplasmic Reticulum Stress Aggrephagy Cellular Response To Hypoxia Autophagosome Maturation Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process	Regulation Of Cell Growth Negative Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation T-helper 1 Cell Lineage Commitment Heart Morphogenesis Heart Valve Morphogenesis Regulation Of Glycogen Biosynthetic Process Energy Reserve Metabolic Process 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Protein Phosphorylation Lysosome Organization Cell Cycle Arrest Germ Cell Development Brain Development Cell Aging Response To Nutrient Long-term Memory Regulation Of Cell Size Visual Learning Cellular Response To Starvation Post-embryonic Development Negative Regulation Of Autophagy Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Myotube Differentiation Positive Regulation Of Neuron Projection Development Positive Regulation Of Neuron Maturation Negative Regulation Of Muscle Atrophy Response To Activity Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Spinal Cord Development Protein Catabolic Process Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Ubiquitination Ruffle Organization Regulation Of Myelination Response To Nutrient Levels Cellular Response To Nutrient Levels TOR Signaling Regulation Of Fatty Acid Beta-oxidation Regulation Of Response To Food Activation Of Protein Kinase B Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Response To Insulin Regulation Of Actin Cytoskeleton Organization Cellular Response To Amino Acid Starvation Social Behavior Multicellular Organism Growth TORC1 Signaling Wound Healing Response To Cocaine Regulation Of Circadian Rhythm Regulation Of GTPase Activity Response To Amino Acid Anoikis Response To Morphine Regulation Of Carbohydrate Utilization Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Osteoclast Differentiation Positive Regulation Of Translation Negative Regulation Of Cell Size Positive Regulation Of Transcription By RNA Polymerase III Protein Autophosphorylation Positive Regulation Of Lipid Biosynthetic Process MRNA Stabilization Rhythmic Process Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Voluntary Musculoskeletal Movement Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Keratinocyte Migration Nucleus Localization Positive Regulation Of Protein Kinase B Signaling Cardiac Muscle Cell Development Cardiac Muscle Contraction Maternal Process Involved In Female Pregnancy Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Dendritic Spine Development Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Amino Acid Stimulus Cellular Response To Leucine Cellular Response To Hypoxia Regulation Of Brown Fat Cell Differentiation Regulation Of Membrane Permeability Regulation Of Translation At Synapse, Modulating Synaptic Transmission Regulation Of Cellular Response To Heat Positive Regulation Of Neuron Death Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Eating Behavior Positive Regulation Of Cholangiocyte Proliferation Positive Regulation Of Sensory Perception Of Pain Regulation Of Locomotor Rhythm Negative Regulation Of Cholangiocyte Apoptotic Process Positive Regulation Of Granulosa Cell Proliferation Positive Regulation Of Skeletal Muscle Hypertrophy Negative Regulation Of Iodide Transmembrane Transport Positive Regulation Of Cytoplasmic Translational Initiation Cellular Response To Leucine Starvation
Pathways		Cargo recognition for clathrin-mediated endocytosis	PIP3 activates AKT signaling Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs			Pimecrolimus Sirolimus Everolimus Rimiducid SF1126 XL765 Ridaforolimus Temsirolimus Fostamatinib
Diseases
GWAS		Metabolite levels ( 23823483) Refractive error ( 32231278)	Beard thickness ( 26926045) Body mass index ( 25673413) Corneal curvature ( 24963161) Heel bone mineral density ( 28869591) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		233 interacting genes: ABCC2 ACOT7 ADRM1 AGPAT5 AGR2 AGR3 ANOS1 APOC2 APOC4 APP ASCL1 ATXN3 BAG6 BPIFA1 C1QA C1QTNF2 C1QTNF4 CALU CCL3 CCL7 CD47 CD99 CD99L2 CDIP1 CDSN CHGB CHRNA3 CHRNA4 CHRNB4 CLCN2 COL10A1 COL1A2 COL9A2 COLGALT2 COMTD1 COPS4 CSN3 CSTF2 CSTF2T CTAG1A CTAG1B CTAG2 CYB5R1 DAZAP2 DEFA6 DEFB115 DESI1 DEXI DMKN DNAJB2 DOLK ECM1 EFEMP2 EP300 EPS15 ERP27 ERP29 ETNK1 F8 FAM163B FAM189A2 FAM86B3P FAS FBXO25 FCGR2A FGF7 FKBP2 FN1 FOLR3 FZD7 GABRA1 GABRA2 GABRA3 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GAL GHRL GIT2 GKAP1 GPR162 GPX3 GRM2 GUCA2A GUCA2B GYPB HERC3 HES1 HGS HK2 HSD17B12 HSPA13 IER3IP1 IGFBP6 IGL IGLC1 IGLV2-14 IL6ST IRF1-AS1 IST1 ITPRIPL1 JPH4 JSRP1 KLHL42 LAIR2 LAMB1 LCN2 LHX4 LITAF LNPEP MANBAL MAP3K1 MCM7 MDK MESD MICOS10-NBL1 MIEF1 MIEF2 MLLT6 MTNR1A MTOR MYDGF NAXD NBL1 NDE1 NDOR1 NEDD8 NGLY1 NLGN3 NME3 NPPA NPY NT5C3A NUP58 NXF1 OST4 P4HB PARVA PBXIP1 PCDH18 PCDHA4 PIAS2 PIK3IP1 PLAAT1 PLAAT2 PLAAT3 PNMA1 PPIB PPIC PRAP1 PRB1 PRPF40A PRR4 PSEN1 PSEN2 PSMD4 PSMD6 PSORS1C2 PTN RAI2 RARA RASSF5 RIC8A RNF144B RNF208 RNF4 RPN1 RPS27A RSRC2 RTL8A RTL8B RTL8C SCG2 SCG5 SCMH1 SERPINE1 SERPINI2 SEZ6L SIL1 SLC16A3 SLC29A2 SLPI SMAD9 SMIM19 SMIM2 SMR3B SMURF1 SOD3 SPAG8 SPARC SRGN STAM2 STMN3 SYNJ2BP TARDBP TFF1 TICAM1 TLR4 TMCO6 TMEM258 TMEM31 TMEM37 TMEM67 TMUB2 TNFRSF1A TNFRSF1B TREX1 TRIM23 TRIM32 TXNDC12 UBA52 UBB UBC UBE2I UBE2V1 UBE3A UBQLN2 UBQLN4 UBXN1 UBXN4 UBXN7 VWC2 WBP2 WFDC12 XPO4 ZBTB8B ZFAND2B ZG16 ZG16B ZMYM5 ZNF343	52 interacting genes: AKT1 AKT1S1 AMBRA1 BCL2L1 C7orf25 CDC37 CFP CLIP1 DCP2 EIF3F EIF4EBP1 EIF4EBP2 EP300 ESR1 FBXO8 FKBP1A FKBP8 GPHN GSK3B HRAS IRS1 MAF1 MLST8 NRAS PA2G4 PDPK1 PLD2 PPP2R2A PREX1 PRKAA1 PRKCA PRR5L RHEB RHEBL1 RICTOR RPS6KA1 RPS6KB1 RPS6KB2 RPTOR RRAGB SEPTIN2 SKP2 STAT3 SUMO1 TELO2 TERT TRAF6 UBQLN1 UVRAG WIPI2 YWHAQ ZNRF2
Entrez ID		29979	2475
HPRD ID		05440	03134
Ensembl ID		ENSG00000135018	ENSG00000198793
Uniprot IDs		A0A024R258 Q9UMX0	P42345
PDB IDs		2JY5 2JY6 2KLC	1AUE 1FAP 1NSG 2FAP 2GAQ 2NPU 2RSE 3FAP 3JBZ 4DRH 4DRI 4DRJ 4FAP 4JSN 4JSP 4JSV 4JSX 4JT5 4JT6 5FLC 5GPG 5H64 5WBH 5WBU 5WBY 5ZCS 6BCU 6BCX 6M4U 6M4W 6SB0 6SB2
Enriched GO Terms of Interacting Partners?
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