FBXO25 and PIP4K2C

Data Source:
BioGRID (enzymatic study)

		FBXO25	PIP4K2C
Description		F-box protein 25	phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex	Nucleoplasm Autophagosome Endoplasmic Reticulum Cytosol Plasma Membrane Intracellular Organelle Extracellular Exosome
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity	Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidylinositol-5-phosphate 4-kinase Activity Identical Protein Binding
	Biological Process	Protein Ubiquitination	Phosphatidylinositol Biosynthetic Process Regulation Of Autophagy Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphorylation Negative Regulation Of 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Biosynthetic Process Positive Regulation Of Autophagosome Assembly
Pathways			Synthesis of PIPs at the plasma membrane PI5P Regulates TP53 Acetylation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Synthesis of PIPs in the nucleus
Drugs			Fostamatinib
Diseases
GWAS		Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)	Rheumatoid arthritis ( 18794853)
Interacting Genes		82 interacting genes: ANKRD13A APLF AXL BMX BRME1 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1	4 interacting genes: APP BTK FBXO25 PJA1
Entrez ID		26260	79837
HPRD ID		16439	15138
Ensembl ID		ENSG00000147364	ENSG00000166908
Uniprot IDs		A0A024QZ88 Q8TCJ0	B3KQV3 Q8TBX8
PDB IDs			2GK9
Enriched GO Terms of Interacting Partners?
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