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TUBA1A and HDAC6
Data Source:
BioGRID
(enzymatic study)
TUBA1A
HDAC6
Description
tubulin alpha 1a
histone deacetylase 6
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Microtubule
Cytoplasmic Microtubule
Microtubule Cytoskeleton
Neuromuscular Junction
Cytoplasmic Ribonucleoprotein Granule
Myelin Sheath
Membrane Raft
Recycling Endosome
Extracellular Exosome
Histone Deacetylase Complex
Nucleus
Nucleoplasm
Cytoplasm
Multivesicular Body
Cytosol
Microtubule
Microtubule Associated Complex
Caveola
Inclusion Body
Aggresome
Dynein Complex
Axon
Dendrite
Cell Leading Edge
Perikaryon
Perinuclear Region Of Cytoplasm
Molecular Function
GTPase Activity
Structural Molecule Activity
Structural Constituent Of Cytoskeleton
Protein Binding
GTP Binding
Protein Domain Specific Binding
Identical Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Corepressor Binding
Actin Binding
Histone Deacetylase Activity
Protein Binding
Beta-catenin Binding
Microtubule Binding
Zinc Ion Binding
Enzyme Binding
Polyubiquitin Modification-dependent Protein Binding
Ubiquitin Protein Ligase Binding
NAD-dependent Histone Deacetylase Activity (H3-K14 Specific)
Protein Deacetylase Activity
Histone Deacetylase Binding
Tubulin Deacetylase Activity
Alpha-tubulin Binding
Ubiquitin Binding
Acetylspermidine Deacetylase Activity
Tau Protein Binding
Beta-tubulin Binding
Misfolded Protein Binding
Hsp90 Protein Binding
Dynein Complex Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Microtubule Cytoskeleton Organization
Mitotic Cell Cycle
Microtubule-based Process
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cytoskeleton-dependent Intracellular Transport
Regulation Of Synapse Organization
Cell Division
Ciliary Basal Body-plasma Membrane Docking
Protein Polyubiquitination
Protein Deacetylation
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
Intracellular Protein Transport
Autophagy
Negative Regulation Of Microtubule Depolymerization
Regulation Of Autophagy
Positive Regulation Of Epithelial Cell Migration
Negative Regulation Of Hydrogen Peroxide Metabolic Process
Regulation Of Macroautophagy
Histone Deacetylation
Negative Regulation Of Protein-containing Complex Assembly
Regulation Of Protein Stability
Protein Destabilization
Lysosome Localization
Protein-containing Complex Disassembly
Positive Regulation Of Peptidyl-serine Phosphorylation
Peptidyl-lysine Deacetylation
Cellular Response To Topologically Incorrect Protein
Regulation Of Gene Expression, Epigenetic
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Negative Regulation Of Protein-containing Complex Disassembly
Regulation Of Fat Cell Differentiation
Negative Regulation Of Proteolysis
Negative Regulation Of Transcription, DNA-templated
Collateral Sprouting
Negative Regulation Of Oxidoreductase Activity
Mitochondrion Localization
Response To Misfolded Protein
Cilium Assembly
Regulation Of Microtubule-based Movement
Regulation Of Androgen Receptor Signaling Pathway
Dendritic Spine Morphogenesis
Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization
Regulation Of Establishment Of Protein Localization
Cellular Response To Hydrogen Peroxide
Aggresome Assembly
Polyubiquitinated Misfolded Protein Transport
Hsp90 Deacetylation
Response To Growth Factor
Histone H3 Deacetylation
Cellular Response To Misfolded Protein
Tubulin Deacetylation
Polyamine Deacetylation
Spermidine Deacetylation
Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Signaling Receptor Activity
Pathways
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Gap junction assembly
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Prefoldin mediated transfer of substrate to CCT/TriC
Formation of tubulin folding intermediates by CCT/TriC
Post-chaperonin tubulin folding pathway
Recycling pathway of L1
Recycling pathway of L1
Hedgehog 'off' state
Cilium Assembly
Anchoring of the basal body to the plasma membrane
Intraflagellar transport
RHO GTPases activate IQGAPs
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Carboxyterminal post-translational modifications of tubulin
Carboxyterminal post-translational modifications of tubulin
HCMV Early Events
Assembly and cell surface presentation of NMDA receptors
Activation of AMPK downstream of NMDARs
Aggrephagy
Aggrephagy
EML4 and NUDC in mitotic spindle formation
Sealing of the nuclear envelope (NE) by ESCRT-III
Kinesins
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HSF1 activation
Notch-HLH transcription pathway
Cilium Assembly
Transcriptional regulation by RUNX2
RUNX2 regulates osteoblast differentiation
Chaperone Mediated Autophagy
Late endosomal microautophagy
Aggrephagy
Aggrephagy
Drugs
Albendazole
Vinblastine
Mebendazole
Epothilone D
Patupilone
CYT997
2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Artenimol
Phenethyl Isothiocyanate
Colchiceine
Vorinostat
Belinostat
Pracinostat
Romidepsin
Panobinostat
Bufexamac
Diseases
Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS
Brain morphology (MOSTest) (
32665545
)
Composite immunoglobulin trait (IgG/IgM) (
28628107
)
Interacting Genes
63 interacting genes:
ANXA7
ARL3
ATXN3
B4GALT1
BTG1
C8orf33
CDKN1A
CDKN2A
CEP20
CLIP1
CNP
CPEB2
CXCR1
CYLD
DAG1
DUSP23
EGFR
EML1
GEMIN7
GRM7
GSK3B
GZMB
HDAC6
HTRA2
KEL
KPNB1
LINC01554
LRRK2
MAP2
MAP7D3
MAPK6
MAPRE1
MAX
MX1
MYC
NFATC1
NUDT3
PAFAH1B1
PLA2G7
S100A8
S100A9
SDC3
SIAH1
SMN1
SNCA
SOCS6
SOCS7
SPART
STARD13
STK11
SYK
TAOK2
TBCB
TIMM17A
TK1
TLN1
TTR
TUBB
UBE2D3
VAV1
VCL
YWHAQ
ZAP70
83 interacting genes:
ADRB2
APOBEC3G
ARHGDIA
ATF3
ATXN3
AURKA
BBS10
BCL3
BCOR
BRMS1
CDKN1A
CEP70
CSNK2A2
CTTN
CYLD
DYNLL2
EGFR
EP300
ERBB2
ERBB3
ERBB4
FBP1
FBXO11
FNTA
FNTB
GRK2
H3C1
H4-16
HDAC11
HES1
HSP90AA1
HTATIP2
HTATSF1
ISG15
JDP2
KPNA1
LCOR
LPXN
MAPK1
MAPK3
MAPT
MLH1
MSH2
NACAD
NASP
NR0B2
NR3C1
PLAA
POLA2
POLDIP2
POLR1B
PPP1CC
PRDX4
PRKCZ
PRKN
PROM1
PTOV1
PXN
RELB
RNF31
RUNX2
SEPTIN7
SIRT2
SYK
TPPP
TRIM50
TUBA1A
TUBA1B
TUBA4A
TUBB
TUBB2A
TUBB2B
UBB
UBC
UBE2D1
UBE2D3
UBE2E1
UBE2H
VCP
VKORC1
YWHAZ
ZBTB16
ZNF205
Entrez ID
7846
10013
HPRD ID
03959
02228
Ensembl ID
ENSG00000167552
ENSG00000094631
Uniprot IDs
Q71U36
A0A024QZ26
B4DZH6
Q9BRX7
Q9NSW6
Q9UBN7
PDB IDs
5JCO
6J8F
6WSL
7C1M
3C5K
3GV4
3PHD
5B8D
5EDU
5KH3
5KH7
5KH9
5WBN
5WPB
6CE6
6CE8
6CEA
6CEC
6CED
6CEE
6CEF
Enriched GO Terms of Interacting Partners
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