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CLDN7 and IGFBP5
Data Source:
BioGRID
(two hybrid)
CLDN7
IGFBP5
Description
claudin 7
insulin like growth factor binding protein 5
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Bicellular Tight Junction
Integral Component Of Membrane
Basolateral Plasma Membrane
Apicolateral Plasma Membrane
Lateral Plasma Membrane
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Insulin-like Growth Factor Binding Protein Complex
Insulin-like Growth Factor Ternary Complex
Molecular Function
Structural Molecule Activity
Protein Binding
Protein Domain Specific Binding
Identical Protein Binding
Cell Adhesion Molecule Binding
Fibronectin Binding
Protein Binding
Insulin-like Growth Factor I Binding
Insulin-like Growth Factor II Binding
Biological Process
Cell Adhesion
Negative Regulation Of Cell Adhesion
Positive Regulation Of Cell Population Proliferation
Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules
Negative Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Apoptotic Process
Response To Ethanol
Bicellular Tight Junction Assembly
Positive Regulation Of Cell Motility
Regulation Of Cell Growth
Osteoblast Differentiation
Signal Transduction
Female Pregnancy
Aging
Negative Regulation Of Smooth Muscle Cell Migration
Negative Regulation Of Translation
Negative Regulation Of Cell Migration
Hair Follicle Morphogenesis
Intracellular Signal Transduction
Glucose Homeostasis
Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Post-translational Protein Modification
Cellular Protein Metabolic Process
Type B Pancreatic Cell Proliferation
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of Growth
Lung Alveolus Development
Negative Regulation Of Smooth Muscle Cell Proliferation
Striated Muscle Cell Differentiation
Positive Regulation Of Protein Kinase B Signaling
Mammary Gland Involution
Response To Growth Hormone
Cellular Response To CAMP
Cellular Response To Organic Cyclic Compound
Negative Regulation Of Muscle Tissue Development
Negative Regulation Of Skeletal Muscle Hypertrophy
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways
Tight junction interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Drugs
Diseases
GWAS
Birth weight (
31043758
27680694
)
FEV1 (
30804560
)
Lung function (FVC) (
30804560
)
Multiple sclerosis (
31604244
)
Offspring birth weight (
31043758
)
Blood protein levels (
30072576
29875488
)
Breast cancer (
29059683
)
Creatinine levels (
29403010
)
Estimated glomerular filtration rate (
30604766
)
FEV1 (
30804560
)
Glomerular filtration rate (
27588450
29403010
)
Glomerular filtration rate in non diabetics (creatinine) (
26831199
)
Height (
31562340
)
Hypothyroidism (
27182965
)
Lung function (FEV1/FVC) (
30804560
)
Metabolite levels (
23823483
)
Mitral valve prolapse (
26301497
)
Pulse pressure (
27841878
)
Serum thyroid-stimulating hormone levels (
25436638
)
Thyroid hormone levels (
23408906
)
Thyroid stimulating hormone levels (
32769997
)
Visceral fat (
22589738
)
Interacting Genes
77 interacting genes:
AIG1
ANKRD46
APOD
AQP2
ASGR1
BCL2L2
BET1
BMP10
C3orf52
CD53
CD72
CLN6
CMTM5
CNIH1
COL4A5
CXCL16
CXCL9
CYB561A3
CYB561D2
CYB5B
CYBC1
EDDM3B
EMP3
EPCAM
ERG28
ERMP1
FAXDC2
FXYD6
GIMAP5
GLP1R
GPR37L1
HGD
IGFBP5
ITM2A
JAGN1
LAT
LEPROTL1
LPAR3
LSMEM2
MAL
MALL
MFSD5
MS4A13
NDUFB11
NIPAL4
NKG7
OLFM4
PGAP2
PLN
RHOXF2
RPRM
RTP2
SCAMP4
SCARF1
SEC22B
SERTM1
SLC38A7
SYNE4
TJP1
TMEM100
TMEM11
TMEM128
TMEM140
TMEM147
TMEM44
TMEM60
TMEM97
TNF
TRARG1
TSPAN33
UBIAD1
UNC93B1
UPK1B
UPK2
VAMP3
VAMP5
VSTM1
92 interacting genes:
ABHD4
ADAM12
AHNAK2
AMIGO1
ANKS6
APH1A
AQP2
AQP6
AQP9
ASGR1
BAG6
BSND
CD53
CERS4
CHODL
CLDN2
CLDN20
CLDN6
CLDN7
CLDN9
CLEC17A
CREB3
CXCR1
ELOVL5
ERGIC3
F2
FAM209A
FCRL3
FHL1
FHL2
FN1
FNDC9
GJA5
GJA8
GJB3
GJB5
GOLM1
GPR151
GPR152
GPR37L1
GPR42
GPRC5D
GPX8
HSD17B13
IGF1
IGF2
IGFALS
KCNK5
KIAA2013
KPNB1
LAPTM4B
LAYN
LDLRAD1
LHFPL1
LMNA
LTBP1
MFF
MFSD5
MRPS18B
MS4A3
MS4A7
NCAPH2
PAPPA2
PDZK1IP1
PNO1
PROKR2
RASSF1
RHCG
SERPINE1
SLC10A6
SLC13A4
SLC38A1
SLC41A2
SLC41A3
SPAG4
SPP1
SYNE4
TF
THAP4
THBS1
TLCD4
TMEM106A
TMEM106C
TMEM179B
TMEM237
TMEM45A
TMEM52B
TMPRSS2
TMX2
TSPAN12
TSPO2
VTN
Entrez ID
1366
3488
HPRD ID
07633
00901
Ensembl ID
ENSG00000181885
ENSG00000115461
Uniprot IDs
A0A384ME58
F5H496
O95471
P24593
PDB IDs
1BOE
1H59
Enriched GO Terms of Interacting Partners
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