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IGFBP5 and THAP4
Data Source:
BioGRID
(two hybrid)
IGFBP5
THAP4
Description
insulin like growth factor binding protein 5
THAP domain containing 4
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Insulin-like Growth Factor Binding Protein Complex
Insulin-like Growth Factor Ternary Complex
Cellular_component
Molecular Function
Fibronectin Binding
Protein Binding
Insulin-like Growth Factor I Binding
Insulin-like Growth Factor II Binding
DNA Binding
Protein Binding
Heme Binding
Identical Protein Binding
Metal Ion Binding
Peroxynitrite Isomerase Activity
Nitric Oxide Binding
Biological Process
Regulation Of Cell Growth
Osteoblast Differentiation
Signal Transduction
Female Pregnancy
Aging
Negative Regulation Of Smooth Muscle Cell Migration
Negative Regulation Of Translation
Negative Regulation Of Cell Migration
Hair Follicle Morphogenesis
Intracellular Signal Transduction
Glucose Homeostasis
Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Post-translational Protein Modification
Cellular Protein Metabolic Process
Type B Pancreatic Cell Proliferation
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of Growth
Lung Alveolus Development
Negative Regulation Of Smooth Muscle Cell Proliferation
Striated Muscle Cell Differentiation
Positive Regulation Of Protein Kinase B Signaling
Mammary Gland Involution
Response To Growth Hormone
Cellular Response To CAMP
Cellular Response To Organic Cyclic Compound
Negative Regulation Of Muscle Tissue Development
Negative Regulation Of Skeletal Muscle Hypertrophy
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Tyrosine Metabolic Process
Nitrate Metabolic Process
Pathways
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Drugs
Diseases
GWAS
Blood protein levels (
30072576
29875488
)
Breast cancer (
29059683
)
Creatinine levels (
29403010
)
Estimated glomerular filtration rate (
30604766
)
FEV1 (
30804560
)
Glomerular filtration rate (
27588450
29403010
)
Glomerular filtration rate in non diabetics (creatinine) (
26831199
)
Height (
31562340
)
Hypothyroidism (
27182965
)
Lung function (FEV1/FVC) (
30804560
)
Metabolite levels (
23823483
)
Mitral valve prolapse (
26301497
)
Pulse pressure (
27841878
)
Serum thyroid-stimulating hormone levels (
25436638
)
Thyroid hormone levels (
23408906
)
Thyroid stimulating hormone levels (
32769997
)
Visceral fat (
22589738
)
Brain structure (
20171287
)
Platelet count (
32888494
)
Prostate cancer (
23535732
)
Thyroid stimulating hormone levels (
32769997
)
Interacting Genes
92 interacting genes:
ABHD4
ADAM12
AHNAK2
AMIGO1
ANKS6
APH1A
AQP2
AQP6
AQP9
ASGR1
BAG6
BSND
CD53
CERS4
CHODL
CLDN2
CLDN20
CLDN6
CLDN7
CLDN9
CLEC17A
CREB3
CXCR1
ELOVL5
ERGIC3
F2
FAM209A
FCRL3
FHL1
FHL2
FN1
FNDC9
GJA5
GJA8
GJB3
GJB5
GOLM1
GPR151
GPR152
GPR37L1
GPR42
GPRC5D
GPX8
HSD17B13
IGF1
IGF2
IGFALS
KCNK5
KIAA2013
KPNB1
LAPTM4B
LAYN
LDLRAD1
LHFPL1
LMNA
LTBP1
MFF
MFSD5
MRPS18B
MS4A3
MS4A7
NCAPH2
PAPPA2
PDZK1IP1
PNO1
PROKR2
RASSF1
RHCG
SERPINE1
SLC10A6
SLC13A4
SLC38A1
SLC41A2
SLC41A3
SPAG4
SPP1
SYNE4
TF
THAP4
THBS1
TLCD4
TMEM106A
TMEM106C
TMEM179B
TMEM237
TMEM45A
TMEM52B
TMPRSS2
TMX2
TSPAN12
TSPO2
VTN
42 interacting genes:
AGTRAP
AIG1
AMD1
ANKRD46
APP
BSND
CACNG1
CD81
CLCA4
CMTM5
CMTM7
COL4A5
CPNE2
CTSA
CYP4F2
DGAT2L6
FKBP7
GIMAP1
GPR37L1
IGFBP5
LAT
LPAR3
MAL2
MAPK6
MOB4
MS4A1
NDRG4
PLP2
RMDN2
RTP2
SCAMP1
SLC30A8
SYP
TMEM107
TMEM60
TMEM86A
TMEM86B
TNFRSF10D
TPD52
TRIM54
TTPA
YIPF6
Entrez ID
3488
51078
HPRD ID
00901
11630
Ensembl ID
ENSG00000115461
ENSG00000176946
Uniprot IDs
P24593
Q8WY91
PDB IDs
1BOE
1H59
3IA8
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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