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IGFBP5 and SLC10A6
Data Source:
BioGRID
(two hybrid)
IGFBP5
SLC10A6
Description
insulin like growth factor binding protein 5
solute carrier family 10 member 6
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Insulin-like Growth Factor Binding Protein Complex
Insulin-like Growth Factor Ternary Complex
Plasma Membrane
Integral Component Of Membrane
Molecular Function
Fibronectin Binding
Protein Binding
Insulin-like Growth Factor I Binding
Insulin-like Growth Factor II Binding
Protein Binding
Bile Acid:sodium Symporter Activity
Sodium-dependent Organic Anion Transmembrane Transporter Activity
Biological Process
Regulation Of Cell Growth
Osteoblast Differentiation
Signal Transduction
Female Pregnancy
Aging
Negative Regulation Of Smooth Muscle Cell Migration
Negative Regulation Of Translation
Negative Regulation Of Cell Migration
Hair Follicle Morphogenesis
Intracellular Signal Transduction
Glucose Homeostasis
Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Post-translational Protein Modification
Cellular Protein Metabolic Process
Type B Pancreatic Cell Proliferation
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of Growth
Lung Alveolus Development
Negative Regulation Of Smooth Muscle Cell Proliferation
Striated Muscle Cell Differentiation
Positive Regulation Of Protein Kinase B Signaling
Mammary Gland Involution
Response To Growth Hormone
Cellular Response To CAMP
Cellular Response To Organic Cyclic Compound
Negative Regulation Of Muscle Tissue Development
Negative Regulation Of Skeletal Muscle Hypertrophy
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Sodium Ion Transport
Bile Acid And Bile Salt Transport
Sodium-dependent Organic Anion Transport
Transmembrane Transport
Pathways
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Transport of bile salts and organic acids, metal ions and amine compounds
Drugs
Diseases
GWAS
Blood protein levels (
30072576
29875488
)
Breast cancer (
29059683
)
Creatinine levels (
29403010
)
Estimated glomerular filtration rate (
30604766
)
FEV1 (
30804560
)
Glomerular filtration rate (
27588450
29403010
)
Glomerular filtration rate in non diabetics (creatinine) (
26831199
)
Height (
31562340
)
Hypothyroidism (
27182965
)
Lung function (FEV1/FVC) (
30804560
)
Metabolite levels (
23823483
)
Mitral valve prolapse (
26301497
)
Pulse pressure (
27841878
)
Serum thyroid-stimulating hormone levels (
25436638
)
Thyroid hormone levels (
23408906
)
Thyroid stimulating hormone levels (
32769997
)
Visceral fat (
22589738
)
Eyebrow thickness (
26926045
)
Insulin-related traits (
22791750
)
Refractive error (
32231278
)
Interacting Genes
92 interacting genes:
ABHD4
ADAM12
AHNAK2
AMIGO1
ANKS6
APH1A
AQP2
AQP6
AQP9
ASGR1
BAG6
BSND
CD53
CERS4
CHODL
CLDN2
CLDN20
CLDN6
CLDN7
CLDN9
CLEC17A
CREB3
CXCR1
ELOVL5
ERGIC3
F2
FAM209A
FCRL3
FHL1
FHL2
FN1
FNDC9
GJA5
GJA8
GJB3
GJB5
GOLM1
GPR151
GPR152
GPR37L1
GPR42
GPRC5D
GPX8
HSD17B13
IGF1
IGF2
IGFALS
KCNK5
KIAA2013
KPNB1
LAPTM4B
LAYN
LDLRAD1
LHFPL1
LMNA
LTBP1
MFF
MFSD5
MRPS18B
MS4A3
MS4A7
NCAPH2
PAPPA2
PDZK1IP1
PNO1
PROKR2
RASSF1
RHCG
SERPINE1
SLC10A6
SLC13A4
SLC38A1
SLC41A2
SLC41A3
SPAG4
SPP1
SYNE4
TF
THAP4
THBS1
TLCD4
TMEM106A
TMEM106C
TMEM179B
TMEM237
TMEM45A
TMEM52B
TMPRSS2
TMX2
TSPAN12
TSPO2
VTN
146 interacting genes:
ACSL5
ANKRD46
APOD
ARL6IP1
ARV1
ATP13A1
BMP10
BTN2A2
C11orf24
C2CD2L
CCDC167
CCL4
CDIPT
CDS1
CLDND2
CMTM5
CNIH1
COL4A5
COMT
COX20
CYB5B
CYB5R3
CYP4F2
DERL1
DGAT2L6
EMC6
ERG28
FA2H
FAM3C
FAXDC2
FIS1
FKBP8
FMO1
FUNDC2
FXYD3
FXYD6
FXYD6-FXYD2
GIMAP1
GJB6
GLB1
GOLT1B
GOSR2
GPR151
GYPA
GYPC
HTATIP2
IGFBP5
ITGAM
LPAR3
LSS
MALL
MFSD5
MFSD6
MGLL
MS4A1
NAT8
NEU1
NINJ2
NRM
OR7D4
ORMDL1
OSMR
PEDS1-UBE2V1
PEX16
PIP4P1
PIP4P2
PLLP
PLP1
PNLIPRP1
PRAF2
PRRT2
PSEN1
PSENEN
RNF24
RTP2
RUSF1
SACM1L
SCAMP4
SCAMP5
SCD
SERP1
SERP2
SFT2D2
SFXN1
SLC12A7
SLC25A46
SLC29A2
SLC30A2
SLC30A3
SLC35C2
SLC35G2
SLC38A1
SLC39A6
SLC39A9
SLC41A1
SLC66A2
SLC7A1
SMAGP
SMIM1
SNORC
STATH
STX12
STX7
STX8
SYNGR1
SYNJ2BP
TAP1
TECR
TF
TM4SF4
TMEM107
TMEM11
TMEM119
TMEM120B
TMEM128
TMEM143
TMEM14A
TMEM14C
TMEM203
TMEM208
TMEM218
TMEM229B
TMEM234
TMEM239
TMEM242
TMEM252
TMEM262
TMEM50B
TMEM60
TMEM65
TMEM86A
TMEM86B
TPRG1
TREX1
TSNARE1
TSPAN2
TSPO2
TVP23B
UBE2J1
UNC50
VAMP4
YIPF1
YIPF2
YIPF6
ZDHHC15
ZFPL1
Entrez ID
3488
345274
HPRD ID
00901
11593
Ensembl ID
ENSG00000115461
ENSG00000145283
Uniprot IDs
P24593
Q3KNW5
PDB IDs
1BOE
1H59
Enriched GO Terms of Interacting Partners
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