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IGFBP5 and GPR37L1
Data Source:
BioGRID
(two hybrid)
IGFBP5
GPR37L1
Description
insulin like growth factor binding protein 5
G protein-coupled receptor 37 like 1
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Insulin-like Growth Factor Binding Protein Complex
Insulin-like Growth Factor Ternary Complex
Plasma Membrane
Integral Component Of Membrane
Receptor Complex
Ciliary Membrane
Molecular Function
Fibronectin Binding
Protein Binding
Insulin-like Growth Factor I Binding
Insulin-like Growth Factor II Binding
G Protein-coupled Receptor Activity
Protein Binding
G Protein-coupled Peptide Receptor Activity
Prosaposin Receptor Activity
Peptide Binding
Biological Process
Regulation Of Cell Growth
Osteoblast Differentiation
Signal Transduction
Female Pregnancy
Aging
Negative Regulation Of Smooth Muscle Cell Migration
Negative Regulation Of Translation
Negative Regulation Of Cell Migration
Hair Follicle Morphogenesis
Intracellular Signal Transduction
Glucose Homeostasis
Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Post-translational Protein Modification
Cellular Protein Metabolic Process
Type B Pancreatic Cell Proliferation
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of Growth
Lung Alveolus Development
Negative Regulation Of Smooth Muscle Cell Proliferation
Striated Muscle Cell Differentiation
Positive Regulation Of Protein Kinase B Signaling
Mammary Gland Involution
Response To Growth Hormone
Cellular Response To CAMP
Cellular Response To Organic Cyclic Compound
Negative Regulation Of Muscle Tissue Development
Negative Regulation Of Skeletal Muscle Hypertrophy
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Negative Regulation Of Systemic Arterial Blood Pressure
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation
Positive Regulation Of MAPK Cascade
Negative Regulation Of Neuron Differentiation
Negative Regulation Of Smoothened Signaling Pathway
Negative Regulation Of Astrocyte Differentiation
Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Pathways
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Peptide ligand-binding receptors
G alpha (i) signalling events
Drugs
Diseases
GWAS
Blood protein levels (
30072576
29875488
)
Breast cancer (
29059683
)
Creatinine levels (
29403010
)
Estimated glomerular filtration rate (
30604766
)
FEV1 (
30804560
)
Glomerular filtration rate (
27588450
29403010
)
Glomerular filtration rate in non diabetics (creatinine) (
26831199
)
Height (
31562340
)
Hypothyroidism (
27182965
)
Lung function (FEV1/FVC) (
30804560
)
Metabolite levels (
23823483
)
Mitral valve prolapse (
26301497
)
Pulse pressure (
27841878
)
Serum thyroid-stimulating hormone levels (
25436638
)
Thyroid hormone levels (
23408906
)
Thyroid stimulating hormone levels (
32769997
)
Visceral fat (
22589738
)
Age at first sexual intercourse (
27089180
)
Diverticular disease (
30177863
)
Interacting Genes
92 interacting genes:
ABHD4
ADAM12
AHNAK2
AMIGO1
ANKS6
APH1A
AQP2
AQP6
AQP9
ASGR1
BAG6
BSND
CD53
CERS4
CHODL
CLDN2
CLDN20
CLDN6
CLDN7
CLDN9
CLEC17A
CREB3
CXCR1
ELOVL5
ERGIC3
F2
FAM209A
FCRL3
FHL1
FHL2
FN1
FNDC9
GJA5
GJA8
GJB3
GJB5
GOLM1
GPR151
GPR152
GPR37L1
GPR42
GPRC5D
GPX8
HSD17B13
IGF1
IGF2
IGFALS
KCNK5
KIAA2013
KPNB1
LAPTM4B
LAYN
LDLRAD1
LHFPL1
LMNA
LTBP1
MFF
MFSD5
MRPS18B
MS4A3
MS4A7
NCAPH2
PAPPA2
PDZK1IP1
PNO1
PROKR2
RASSF1
RHCG
SERPINE1
SLC10A6
SLC13A4
SLC38A1
SLC41A2
SLC41A3
SPAG4
SPP1
SYNE4
TF
THAP4
THBS1
TLCD4
TMEM106A
TMEM106C
TMEM179B
TMEM237
TMEM45A
TMEM52B
TMPRSS2
TMX2
TSPAN12
TSPO2
VTN
52 interacting genes:
ADGRB3
AQP1
AQP10
ARL13B
CD46
CISD2
CLDN7
CLDND2
CLEC2A
CREB3L1
CYB561A3
ELOVL4
ERG28
FAM209A
FFAR2
FXYD3
FXYD6-FXYD2
GPR152
GPR42
GPX8
IGFBP5
INSIG2
JAGN1
LHFPL5
PDCD1LG2
PLN
PRH1
RNF122
RPRM
SCARB2
SCARF1
SEC22A
SERP1
SLC30A8
STOM
SYNPR
THAP4
THSD7B
TM4SF4
TMEM147
TMEM243
TMEM248
TMEM52B
TMEM54
TMEM80
TMEM86A
TMEM86B
TMEM97
TNFRSF10C
TSPAN12
UNC93B1
UPK1B
Entrez ID
3488
9283
HPRD ID
00901
13603
Ensembl ID
ENSG00000115461
ENSG00000170075
Uniprot IDs
P24593
O60883
PDB IDs
1BOE
1H59
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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