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IGFBP5 and SERPINE1
Data Source:
HPRD
(in vitro, in vivo)
IGFBP5
SERPINE1
Description
insulin like growth factor binding protein 5
serpin family E member 1
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Insulin-like Growth Factor Binding Protein Complex
Insulin-like Growth Factor Ternary Complex
Extracellular Region
Extracellular Space
Plasma Membrane
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Molecular Function
Fibronectin Binding
Protein Binding
Insulin-like Growth Factor I Binding
Insulin-like Growth Factor II Binding
Protease Binding
Serine-type Endopeptidase Inhibitor Activity
Signaling Receptor Binding
Protein Binding
Biological Process
Regulation Of Cell Growth
Osteoblast Differentiation
Signal Transduction
Female Pregnancy
Aging
Negative Regulation Of Smooth Muscle Cell Migration
Negative Regulation Of Translation
Negative Regulation Of Cell Migration
Hair Follicle Morphogenesis
Intracellular Signal Transduction
Glucose Homeostasis
Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Post-translational Protein Modification
Cellular Protein Metabolic Process
Type B Pancreatic Cell Proliferation
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of Growth
Lung Alveolus Development
Negative Regulation Of Smooth Muscle Cell Proliferation
Striated Muscle Cell Differentiation
Positive Regulation Of Protein Kinase B Signaling
Mammary Gland Involution
Response To Growth Hormone
Cellular Response To CAMP
Cellular Response To Organic Cyclic Compound
Negative Regulation Of Muscle Tissue Development
Negative Regulation Of Skeletal Muscle Hypertrophy
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Angiogenesis
Platelet Degranulation
Circadian Rhythm
Regulation Of Signaling Receptor Activity
Negative Regulation Of Plasminogen Activation
Negative Regulation Of Endopeptidase Activity
Negative Regulation Of Smooth Muscle Cell Migration
Positive Regulation Of Blood Coagulation
Negative Regulation Of Blood Coagulation
Extracellular Matrix Organization
Negative Regulation Of Cell Migration
Positive Regulation Of Interleukin-8 Production
Negative Regulation Of Cell Adhesion Mediated By Integrin
Positive Regulation Of Leukotriene Production Involved In Inflammatory Response
Fibrinolysis
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Receptor-mediated Endocytosis
Positive Regulation Of Inflammatory Response
Defense Response To Gram-negative Bacterium
Negative Regulation Of Fibrinolysis
Negative Regulation Of Vascular Wound Healing
Negative Regulation Of Wound Healing
Cellular Response To Lipopolysaccharide
Positive Regulation Of Monocyte Chemotaxis
Replicative Senescence
Dentinogenesis
Positive Regulation Of Odontoblast Differentiation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Smooth Muscle Cell-matrix Adhesion
Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Platelet degranulation
BMAL1:CLOCK,NPAS2 activates circadian gene expression
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
ECM proteoglycans
Dissolution of Fibrin Clot
Drugs
Alteplase
Urokinase
Reteplase
Anistreplase
Tenecteplase
Drotrecogin alfa
Troglitazone
Fibrinolysin
Copper
Diseases
Inherited thrombophilia
GWAS
Blood protein levels (
30072576
29875488
)
Breast cancer (
29059683
)
Creatinine levels (
29403010
)
Estimated glomerular filtration rate (
30604766
)
FEV1 (
30804560
)
Glomerular filtration rate (
27588450
29403010
)
Glomerular filtration rate in non diabetics (creatinine) (
26831199
)
Height (
31562340
)
Hypothyroidism (
27182965
)
Lung function (FEV1/FVC) (
30804560
)
Metabolite levels (
23823483
)
Mitral valve prolapse (
26301497
)
Pulse pressure (
27841878
)
Serum thyroid-stimulating hormone levels (
25436638
)
Thyroid hormone levels (
23408906
)
Thyroid stimulating hormone levels (
32769997
)
Visceral fat (
22589738
)
Blood protein levels (
30072576
)
Nonunion in individuals with fractures (
30680360
)
Plasma plasminogen activator levels (
24578379
)
Plasminogen activator inhibitor type 1 levels (PAI-1) (
22990020
)
Interacting Genes
92 interacting genes:
ABHD4
ADAM12
AHNAK2
AMIGO1
ANKS6
APH1A
AQP2
AQP6
AQP9
ASGR1
BAG6
BSND
CD53
CERS4
CHODL
CLDN2
CLDN20
CLDN6
CLDN7
CLDN9
CLEC17A
CREB3
CXCR1
ELOVL5
ERGIC3
F2
FAM209A
FCRL3
FHL1
FHL2
FN1
FNDC9
GJA5
GJA8
GJB3
GJB5
GOLM1
GPR151
GPR152
GPR37L1
GPR42
GPRC5D
GPX8
HSD17B13
IGF1
IGF2
IGFALS
KCNK5
KIAA2013
KPNB1
LAPTM4B
LAYN
LDLRAD1
LHFPL1
LMNA
LTBP1
MFF
MFSD5
MRPS18B
MS4A3
MS4A7
NCAPH2
PAPPA2
PDZK1IP1
PNO1
PROKR2
RASSF1
RHCG
SERPINE1
SLC10A6
SLC13A4
SLC38A1
SLC41A2
SLC41A3
SPAG4
SPP1
SYNE4
TF
THAP4
THBS1
TLCD4
TMEM106A
TMEM106C
TMEM179B
TMEM237
TMEM45A
TMEM52B
TMPRSS2
TMX2
TSPAN12
TSPO2
VTN
25 interacting genes:
ACTN4
ELANE
F2
HSD17B11
IGFBP5
KLK2
KRT18
LMNA
LRP1
LRP1B
LRP2
MMP3
ORM1
PITX1
PLAT
PLAU
PLG
SGTA
SGTB
TLX3
TMEM237
UBQLN1
UBQLN2
UBQLN4
VTN
Entrez ID
3488
5054
HPRD ID
00901
01418
Ensembl ID
ENSG00000115461
ENSG00000106366
Uniprot IDs
P24593
A0A024QYT5
P05121
PDB IDs
1BOE
1H59
1A7C
1B3K
1C5G
1DB2
1DVM
1DVN
1LJ5
1OC0
3CVM
3EOX
3PB1
3Q02
3Q03
3R4L
3UT3
4AQH
4G8O
4G8R
4IC0
5BRR
5ZLZ
6GWN
6GWP
6GWQ
6I8S
6ZRV
9PAI
Enriched GO Terms of Interacting Partners
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