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IGFBP5 and GPX8
Data Source:
BioGRID
(two hybrid)
IGFBP5
GPX8
Description
insulin like growth factor binding protein 5
glutathione peroxidase 8 (putative)
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Insulin-like Growth Factor Binding Protein Complex
Insulin-like Growth Factor Ternary Complex
Endoplasmic Reticulum Lumen
Integral Component Of Membrane
Molecular Function
Fibronectin Binding
Protein Binding
Insulin-like Growth Factor I Binding
Insulin-like Growth Factor II Binding
Peroxidase Activity
Glutathione Peroxidase Activity
Protein Binding
Biological Process
Regulation Of Cell Growth
Osteoblast Differentiation
Signal Transduction
Female Pregnancy
Aging
Negative Regulation Of Smooth Muscle Cell Migration
Negative Regulation Of Translation
Negative Regulation Of Cell Migration
Hair Follicle Morphogenesis
Intracellular Signal Transduction
Glucose Homeostasis
Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Post-translational Protein Modification
Cellular Protein Metabolic Process
Type B Pancreatic Cell Proliferation
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of Growth
Lung Alveolus Development
Negative Regulation Of Smooth Muscle Cell Proliferation
Striated Muscle Cell Differentiation
Positive Regulation Of Protein Kinase B Signaling
Mammary Gland Involution
Response To Growth Hormone
Cellular Response To CAMP
Cellular Response To Organic Cyclic Compound
Negative Regulation Of Muscle Tissue Development
Negative Regulation Of Skeletal Muscle Hypertrophy
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Cellular Response To Oxidative Stress
Cellular Oxidant Detoxification
Pathways
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Detoxification of Reactive Oxygen Species
Drugs
Glutathione
Glutathione disulfide
Diseases
GWAS
Blood protein levels (
30072576
29875488
)
Breast cancer (
29059683
)
Creatinine levels (
29403010
)
Estimated glomerular filtration rate (
30604766
)
FEV1 (
30804560
)
Glomerular filtration rate (
27588450
29403010
)
Glomerular filtration rate in non diabetics (creatinine) (
26831199
)
Height (
31562340
)
Hypothyroidism (
27182965
)
Lung function (FEV1/FVC) (
30804560
)
Metabolite levels (
23823483
)
Mitral valve prolapse (
26301497
)
Pulse pressure (
27841878
)
Serum thyroid-stimulating hormone levels (
25436638
)
Thyroid hormone levels (
23408906
)
Thyroid stimulating hormone levels (
32769997
)
Visceral fat (
22589738
)
Cocaine dependence (
31212010
)
Interacting Genes
92 interacting genes:
ABHD4
ADAM12
AHNAK2
AMIGO1
ANKS6
APH1A
AQP2
AQP6
AQP9
ASGR1
BAG6
BSND
CD53
CERS4
CHODL
CLDN2
CLDN20
CLDN6
CLDN7
CLDN9
CLEC17A
CREB3
CXCR1
ELOVL5
ERGIC3
F2
FAM209A
FCRL3
FHL1
FHL2
FN1
FNDC9
GJA5
GJA8
GJB3
GJB5
GOLM1
GPR151
GPR152
GPR37L1
GPR42
GPRC5D
GPX8
HSD17B13
IGF1
IGF2
IGFALS
KCNK5
KIAA2013
KPNB1
LAPTM4B
LAYN
LDLRAD1
LHFPL1
LMNA
LTBP1
MFF
MFSD5
MRPS18B
MS4A3
MS4A7
NCAPH2
PAPPA2
PDZK1IP1
PNO1
PROKR2
RASSF1
RHCG
SERPINE1
SLC10A6
SLC13A4
SLC38A1
SLC41A2
SLC41A3
SPAG4
SPP1
SYNE4
TF
THAP4
THBS1
TLCD4
TMEM106A
TMEM106C
TMEM179B
TMEM237
TMEM45A
TMEM52B
TMPRSS2
TMX2
TSPAN12
TSPO2
VTN
152 interacting genes:
-
AGTRAP
AIG1
ALG8
APOC3
APOD
AQP1
AQP2
AQP3
ASGR1
ASPH
BCL2L2
BET1
BIK
BMP10
BNIP2
BTN2A2
C14orf180
C1GALT1
CACNG1
CD302
CD53
CD81
CDIPT
CDS2
CFHR5
CHST1
CLDN19
CLEC1A
CLEC2A
CMTM5
CNIH1
CNIH3
COL4A5
COL8A2
CORIN
CYB561
CYB561A3
CYB561D2
DNAJC30
DOLK
EDDM3B
ERG28
ERO1A
FA2H
FAM3C
FAXDC2
GET3
GOSR2
GPR151
GPR37L1
GRINA
GYPA
HHATL
HMOX2
IGFBP5
INSIG2
KIR2DL3
KLRG1
LAPTM4B
LEPROTL1
LHFPL5
LNPEP
LPAR3
MAN2B2
MARCHF2
MARCHF5
MFSD5
MFSD6
MGST2
MGST3
MIP
MMD
MYADML2
NEU1
NINJ1
NIPAL3
NKG7
NRM
OCLN
PAEP
PAQR5
PAQR6
PGAP2
PLLP
PLN
PLP2
PLPP4
PLPP6
PNLIPRP1
PRB1
RBFA
RND1
RTP2
SCARB2
SCARF1
SCD
SEC22B
SELENOK
SERINC1
SERINC2
SERP1
SERTM1
SFTPC
SGMS2
SLC13A3
SLC30A3
SLC34A3
SLC35A1
SLC35B4
SLC41A2
SMAGP
SNORC
ST6GAL2
STX3
STX8
SYT15
TF
THBD
TIMMDC1
TM4SF4
TMBIM6
TMEM107
TMEM109
TMEM120B
TMEM128
TMEM14B
TMEM19
TMEM218
TMEM229B
TMEM243
TMEM254
TMEM42
TMEM50B
TMEM60
TMEM86B
TMEM97
TMPRSS4
TMUB2
TRAM1L1
TSPAN33
UNC50
UPK1B
VAMP3
VAMP4
VAMP5
VKORC1L1
VSTM1
VTI1B
YIF1A
YIPF6
ZDHHC22
Entrez ID
3488
493869
HPRD ID
00901
17416
Ensembl ID
ENSG00000115461
ENSG00000164294
Uniprot IDs
P24593
B4DPY0
E7ETY7
J3KNB5
Q8TED1
PDB IDs
1BOE
1H59
3CYN
3KIJ
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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