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PRPF31 and CDC23
Data Source:
BioGRID
(two hybrid)
PRPF31
CDC23
Description
pre-mRNA processing factor 31
cell division cycle 23
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
U2-type Spliceosomal Complex
U4 SnRNP
U4atac SnRNP
Cajal Body
Nuclear Speck
U4/U6 X U5 Tri-snRNP Complex
U2-type Precatalytic Spliceosome
Precatalytic Spliceosome
MLL1 Complex
Spliceosomal Tri-snRNP Complex
Nucleoplasm
Anaphase-promoting Complex
Cytoplasm
Cytosol
Molecular Function
RNA Binding
Protein Binding
U4 SnRNA Binding
U4atac SnRNA Binding
Identical Protein Binding
Ribonucleoprotein Complex Binding
SnRNP Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Biological Process
Spliceosomal Tri-snRNP Complex Assembly
MRNA Splicing, Via Spliceosome
SnoRNA Localization
Ribonucleoprotein Complex Localization
Mitotic Cell Cycle
Ubiquitin-dependent Protein Catabolic Process
Mitotic Metaphase Plate Congression
Metaphase/anaphase Transition Of Mitotic Cell Cycle
Regulation Of Exit From Mitosis
Protein Ubiquitination
Regulation Of Mitotic Metaphase/anaphase Transition
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Cell Division
Protein K11-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Pathways
mRNA Splicing - Major Pathway
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
Retinitis pigmentosa (RP)
GWAS
Change in HbA1c levels in response to metformin treatment in type 2 diabetes (
29650774
)
Autism spectrum disorder or schizophrenia (
28540026
)
Resting heart rate (
27798624
)
Interacting Genes
135 interacting genes:
ASB15
BHLHB9
BICD2
C1QTNF1
CALCOCO2
CAPNS2
CARD14
CBY2
CCDC106
CCDC136
CCDC33
CCDC57
CCDC70
CCNDBP1
CDC23
CDCA7L
CDR2L
CEP70
CYSRT1
DVL2
DVL3
EFEMP2
EVI5
FANCA
FANCC
FASTK
FLACC1
FSD2
FXR1
GOLGA2
GOLGA6L9
HAP1
HES7
HNRNPH2
HNRNPK
HOOK2
HSF2BP
JAKMIP2
KANK2
KCTD6
KHDRBS2
KHDRBS3
KIFC3
KRT15
KRT31
KRT34
KRT35
KRT40
KRTAP1-1
KRTAP1-3
KRTAP10-1
KRTAP10-3
KRTAP10-8
KRTAP10-9
KRTAP19-5
KRTAP4-11
KRTAP6-3
LBX1
LDOC1
LHX8
LURAP1
LZTS2
MDFI
MEIS3
MEOX2
MID2
MIPOL1
MKRN3
MTUS2
NCAPH2
NCKIPSD
NOTCH2NLA
PAK5
PDE4DIP
PHC2
PHF5A
PICK1
PLEKHG4
PNMA1
PNMA2
PNMA3
PPIH
PPP1R16A
PPP2R3C
PRDM14
PRICKLE1
PRPF3
PSTPIP1
RACK1
RBAK
RBM25
RBM4
RBMX
RBMY1A1
RBMY1F
RBMY1J
REL
RINT1
RUNDC3A
SIAH1
SLAIN1
SNRNP200
SRSF3
SSX2IP
STX11
TADA2A
TFIP11
TLE5
TMCC2
TP53BP2
TRIM14
TRIM23
TRIM27
TRIM41
TSGA10
UBXN11
USH1G
USP15
VWC2
ZFP64
ZFP69B
ZNF24
ZNF250
ZNF408
ZNF417
ZNF473
ZNF48
ZNF587
ZNF668
ZNF71
ZNF774
ZNF792
ZNF837
ZRANB1
ZSCAN22
81 interacting genes:
ANAPC10
ANAPC13
ANKRD11
APOL1
ATRIP
BCAS3
BEGAIN
BHLHB9
BYSL
C21orf91
CBY2
CCDC125
CCDC24
CCDC33
CDC16
CDT1
CEP44
CERCAM
COIL
CRACR2A
CRTC2
CTBP1
CYB5R2
DCLK1
DEPDC1B
DISC1
DLX6-AS1
EIF5A2
FAM9B
FBXO5
FOXN1
GORASP2
GTPBP8
HEMK1
IHO1
INCA1
INO80E
INPP5J
KCTD6
KDM1A
KRT36
LHX3
LZTS1
LZTS2
MAGED1
MAPK3
NAB2
NRBF2
NUP54
OPTN
PFKFB4
PIH1D2
PNMA5
POU6F2
PROSER3
PRPF31
PRR22
RAC1
RAD54B
RBM15B
RBP3
RBPMS
RSL24D1
RUNX1T1
SIAH1
SLC52A2
SMARCB1
SMUG1
SORBS3
SOX5
SPAG8
SSX2IP
STX2
SUV39H1
TEPSIN
TNIP1
TRIM27
TSC22D4
UBE2S
USP54
ZMAT1
Entrez ID
26121
8697
HPRD ID
05917
07221
Ensembl ID
ENSG00000105618
ENSG00000094880
Uniprot IDs
Q8WWY3
Q9UJX2
PDB IDs
2OZB
3JCR
3SIU
3SIV
5O9Z
6AH0
6AHD
6QW6
6QX9
4UI9
5A31
5G04
5G05
5KHR
5KHU
5L9T
5L9U
5LCW
6Q6G
6Q6H
6TLJ
6TM5
Enriched GO Terms of Interacting Partners
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