ZNF350 and USP21

Data Source:
BioGRID (two hybrid)

		ZNF350	USP21
Description		zinc finger protein 350	ubiquitin specific peptidase 21
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Matrix Nuclear Body Transcription Repressor Complex	Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding	Transcription Coactivator Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity NEDD8-specific Protease Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated	Ubiquitin-dependent Protein Catabolic Process Histone Deubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Neuron Projection Development Positive Regulation Of Transcription, DNA-templated
Pathways		Generic Transcription Pathway SUMOylation of transcription cofactors	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases
Drugs
Diseases
GWAS		Tourette syndrome ( 30818990)
Interacting Genes		6 interacting genes: ATF7IP BRCA1 FBXL17 NEK1 RNF11 USP21	59 interacting genes: ADAMTSL4 ATXN3 AURKA BAP1 BRCA2 CBL CBLC CPSF6 DTX3 EFEMP2 ESPL1 EXOSC10 FOXM1 H2AC18 HOXC10 ISG15 JOSD1 KCTD9 KRT40 LRSAM1 MAPK3 MPP1 NANOG OTUB1 OTUB2 PCGF6 RBCK1 RNF144A RNF185 SENP3 SENP8 SLF1 STAMBP SYNE1 TP53 TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 WDR47 YOD1 ZNF350
Entrez ID		59348	27005
HPRD ID		05663	05291
Ensembl ID		ENSG00000256683	ENSG00000143258
Uniprot IDs		Q9GZX5	Q9UK80
PDB IDs			2Y5B 3I3T 3MTN
Enriched GO Terms of Interacting Partners?
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