ZNF350 and NEK1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZNF350	NEK1
Description		zinc finger protein 350	NIMA related kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Matrix Nuclear Body Transcription Repressor Complex	Pericentriolar Material Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Centriolar Satellite
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding	Protein Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Metal Ion Binding 14-3-3 Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated	Protein Phosphorylation Cell Cycle Peptidyl-tyrosine Phosphorylation DNA Damage Response, Detection Of DNA Damage Cell Division Cilium Assembly
Pathways		Generic Transcription Pathway SUMOylation of transcription cofactors
Drugs			Fostamatinib
Diseases			Short rib-polydactyly syndrome
GWAS		Tourette syndrome ( 30818990)	Autism spectrum disorder or schizophrenia ( 28540026) Night sleep phenotypes ( 27126917) Schizophrenia ( 28991256 25056061 29483656) Supramarginal gyrus volume ( 31530798)
Interacting Genes		6 interacting genes: ATF7IP BRCA1 FBXL17 NEK1 RNF11 USP21	18 interacting genes: ATRX CSN2 CTNNAL1 EXOSC4 FEZ1 FEZ2 KIF3A LRRK1 LRRK2 MFHAS1 MRE11 PPP2R5A PTPRD SIRPA TP53BP1 TSC2 YWHAH ZNF350
Entrez ID		59348	4750
HPRD ID		05663	06847
Ensembl ID		ENSG00000256683	ENSG00000137601
Uniprot IDs		Q9GZX5	Q5JXL9 Q96PY6
PDB IDs			4APC 4B9D
Enriched GO Terms of Interacting Partners?
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