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IGFBP6 and EFEMP2
Data Source:
BioGRID
(two hybrid)
IGFBP6
EFEMP2
Description
insulin like growth factor binding protein 6
EGF containing fibulin extracellular matrix protein 2
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Golgi Apparatus
Insulin-like Growth Factor Binary Complex
Microfibril
Extracellular Region
Basement Membrane
Extracellular Matrix
Collagen-containing Extracellular Matrix
Extracellular Exosome
Elastic Fiber
Extracellular Vesicle
Molecular Function
Fibronectin Binding
Signaling Receptor Binding
Protein Binding
Insulin-like Growth Factor I Binding
Insulin-like Growth Factor II Binding
Identical Protein Binding
Extracellular Matrix Structural Constituent
Calcium Ion Binding
Protein Binding
Heparin Binding
Protein Homodimerization Activity
Biological Process
Activation Of MAPK Activity
Signal Transduction
Negative Regulation Of Cell Population Proliferation
Cell Migration
Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Cellular Protein Metabolic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Aorta Development
Elastic Fiber Assembly
Aorta Smooth Muscle Tissue Morphogenesis
Vascular Associated Smooth Muscle Cell Development
Regulation Of Collagen Fibril Organization
Positive Regulation Of Collagen Fibril Organization
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Aortic Smooth Muscle Cell Differentiation
Positive Regulation Of Smooth Muscle Cell-matrix Adhesion
Pathways
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Molecules associated with elastic fibres
Molecules associated with elastic fibres
Drugs
Diseases
Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS
Disease progression in age-related macular degeneration (adjusted for baseline) (
29346644
)
Acne (severe) (
24927181
)
Adult body size (
32376654
)
Birth weight (
31043758
)
Body size at age 10 (
32376654
)
Retinal detachment or retinal break (
31816047
)
Interacting Genes
37 interacting genes:
ALPP
ANKRD11
AQP1
C1orf74
CCDC116
CCDC28A
CDIPT
CREB5
EFEMP1
EFEMP2
ENKD1
EPDR1
GAS8
GET3
IGF1
IGF2
KRTAP10-8
KRTAP5-7
KRTAP5-9
MBD3
MEIS2
MSGN1
NCALD
PLEKHA7
POU4F2
RABGGTB
RANBP10
SDCBP
SGTA
SMCP
TF
UBAC1
UBQLN1
UBQLN2
UBQLN4
ZNF417
ZNF587
130 interacting genes:
ADAMTSL4
AMMECR1
ANAPC11
AP1M1
APEX2
AQP1
ARRDC3
ATN1
ATXN1
ATXN7
BAG6
C3
C5orf24
CACNA1A
CATSPER1
CCDC33
CCND3
CCNK
CDPF1
CLPP
CNNM3
COL8A1
CREB5
CXCL5
CYSRT1
DGCR6
DOK7
FAM107A
FAM110A
FAM124B
FAM74A4
FAM90A1
FBXW5
FTO
GFI1B
GLRX3
HDAC4
HHEX
HHIPL1
HOXA1
HPCAL1
HSD3B7
HSPA12B
HSPBP1
IGFBP6
IL16
INCA1
ITGB5
KLF1
KRTAP10-8
KRTAP11-1
KRTAP12-2
KRTAP13-3
KRTAP19-5
KRTAP26-1
KRTAP3-2
LBX1
LCE1A
LCE1C
LCE1E
LCE2C
LCE2D
LCE3A
LCE3C
LCE3D
LCE3E
LINGO1
LNX1
MDFI
MEOX2
MRPL12
MXI1
NEDD4L
NOS3
NR1D2
NTM
NUFIP2
OTX1
P2RX7
PIDD1
PITX1
PLSCR1
PLSCR4
PROP1
PRPF31
PRR32
PTGER3
RAB40B
RBAK
RBP3
RBPMS
RERE
RHOXF2
RHPN1
RIBC2
RNF138
SGTA
SGTB
SLC16A5
SLC23A1
SLC25A48
SPACA9
SPATA24
SPATA3
SPATA8
SPRY4
STK16
TCAF1
THAP7
TLE5
TLX3
TP53
TRIB3
TRIM42
UBQLN1
UBQLN4
USP21
ZNF263
ZNF345
ZNF426
ZNF558
ZNF57
ZNF581
ZNF587
ZNF638
ZNF670
ZNF699
ZNF768
ZNF774
ZNF837
Entrez ID
3489
30008
HPRD ID
00902
05221
Ensembl ID
ENSG00000167779
ENSG00000172638
Uniprot IDs
P24592
A0A024R5G1
O95967
Q9H3D5
PDB IDs
1RMJ
2KL7
Enriched GO Terms of Interacting Partners
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