Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
OTX1 and PLA2G10
Data Source:
BioGRID
(two hybrid)
OTX1
PLA2G10
Description
orthodenticle homeobox 1
phospholipase A2 group X
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Acrosomal Vesicle
Extracellular Region
Extracellular Space
Lysosome
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
Sequence-specific Double-stranded DNA Binding
1-alkyl-2-acetylglycerophosphocholine Esterase Activity
Phospholipase Activity
Phospholipase A2 Activity
Calcium Ion Binding
Protein Binding
Phospholipid Binding
Calcium-dependent Phospholipase A2 Activity
Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine)
Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)
Biological Process
Regulation Of Transcription By RNA Polymerase II
Anterior/posterior Pattern Specification
Metencephalon Development
Midbrain Development
Inner Ear Morphogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Diencephalon Morphogenesis
Phospholipid Metabolic Process
Phosphatidic Acid Biosynthetic Process
Phosphatidylserine Metabolic Process
Axon Guidance
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Lipid Storage
Arachidonic Acid Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Prostaglandin Secretion
Low-density Lipoprotein Particle Remodeling
Phosphatidylcholine Catabolic Process
Phosphatidylglycerol Acyl-chain Remodeling
Phosphatidylinositol Acyl-chain Remodeling
Phosphatidylserine Acyl-chain Remodeling
Phosphatidylcholine Acyl-chain Remodeling
Phosphatidylethanolamine Acyl-chain Remodeling
Cholesterol Homeostasis
Regulation Of Macrophage Activation
Negative Regulation Of DNA-binding Transcription Factor Activity
Phosphatidylethanolamine Metabolic Process
Phosphatidylcholine Metabolic Process
Phosphatidylglycerol Metabolic Process
Phosphatidic Acid Metabolic Process
Arachidonic Acid Secretion
Defense Response To Virus
Lysophospholipid Transport
Platelet Activating Factor Catabolic Process
Positive Regulation Of Arachidonic Acid Secretion
Negative Regulation Of Cholesterol Efflux
Positive Regulation Of Acrosome Reaction
Pathways
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Synthesis of PA
Drugs
Varespladib methyl
Crotalus adamanteus antivenin
Agkistrodon piscivorus antivenin
Diseases
GWAS
Fruit consumption (
32066663
)
Neurociticism (
29500382
)
Regular attendance at a religious group (
29970889
)
Risk-taking tendency (4-domain principal component model) (
30643258
)
Cholesteryl ester levels (
31551469
)
Glycerophospholipid levels (
26068415
)
Interacting Genes
144 interacting genes:
ADAM12
ADAMTSL4
ALPP
ANKRD10
ARHGEF17
ARID5A
ATG9B
BHLHB9
C10orf55
C11orf1
CCN4
CERCAM
CH25H
CHIC2
CHRD
CHRDL2
COL8A1
COMP
CTAG2
CYSRT1
DPY30
EFEMP2
ETFDH
FAM168B
FAM72B
FBLN2
FBLN5
FHL5
GEMIN8P4
GPRIN2
GRN
HIVEP1
INTS11
KCNK16
KLHL26
KPRP
KRT31
KRT35
KRT37
KRT81
KRT85
KRTAP1-1
KRTAP1-3
KRTAP1-5
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP11-1
KRTAP12-1
KRTAP12-2
KRTAP12-3
KRTAP12-4
KRTAP13-1
KRTAP13-2
KRTAP13-3
KRTAP17-1
KRTAP19-2
KRTAP19-7
KRTAP2-3
KRTAP2-4
KRTAP22-1
KRTAP26-1
KRTAP3-1
KRTAP3-2
KRTAP3-3
KRTAP4-1
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP4-7
KRTAP5-11
KRTAP5-3
KRTAP5-6
KRTAP5-9
KRTAP6-1
KRTAP6-2
KRTAP6-3
KRTAP7-1
KRTAP9-2
KRTAP9-3
KRTAP9-4
KRTAP9-8
LASP1
LCE1B
LCE1C
LCE1F
LCE2A
LCE2B
LCE2C
LCE2D
LCE4A
LGALS13
M1AP
MDFI
MGAT5B
MIIP
MTNR1B
NBPF19
NDUFAF6
NECTIN3
NHLRC4
NOTCH2NLA
OXER1
PCSK5
PLA2G10
PLEKHG4
PLSCR2
POU2AF1
PRICKLE4
PRR13
PRR22
RBPMS
RGS17
RGS19
RGS20
RNF144B
RTN4R
SLC15A2
SMARCC1
SPRY1
SPRY2
SPRY4
SPRYD7
TEX37
TLE4
TNS2
TRIM42
TRIP6
TSPAN4
UBAP2
USP54
VWC2
VWC2L
WWOX
YPEL3
ZBTB42
ZNF330
ZNF34
49 interacting genes:
AGXT
AQP1
ARID5A
ATXN1
BAG3
BEX2
C1orf94
CATSPER1
CCDC120
CREB5
CYSRT1
FAM222B
FOXH1
GATA5
GNE
HGS
HOXC8
HR
HSF4
INCA1
KPRP
KRTAP11-1
KRTAP26-1
LCE1A
LCE1C
LCE2A
LCE2B
LCE2D
MAL
MAPKBP1
MGAT5B
MYO10
NOXA1
NTAQ1
OTX1
PITX1
PLA2R1
POU4F3
PPP1R32
ROR2
SNRPC
SPAG8
STK16
TBX6
TFG
TLX3
VGLL3
VPS37C
ZC3H10
Entrez ID
5013
8399
HPRD ID
08964
04674
Ensembl ID
ENSG00000115507
ENSG00000069764
Uniprot IDs
P32242
O15496
PDB IDs
1LE6
1LE7
4UY1
5G3M
5OW8
5OWC
6G5J
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?